Clinical Pharmacology, Uses, and Adverse Reactions of Iodinated Contrast Agents: A Primer for the Non-radiologist

Pasternak, Jeffrey J.; Williamson, Eric E.

doi:10.1016/j.mayocp.2012.01.012

Cited by 158 publications

(90 citation statements)

References 81 publications

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“…Of the 65 recorded reactions, morbilliform exanthema was the most common cutaneous manifestation (40 %), followed by urticaria (23.1 %), consistent with previous studies in other countries [13].…”

Section: Discussionsupporting

confidence: 90%

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Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

et al. 2015

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Cutaneous adverse drug reactions (ADRs) are common. However, no prospective study assessing cutaneous ADRs is available for Chinese populations. This study aimed to assess the incidence, manifestations, causative drugs, and other factors related to cutaneous ADRs. A total of 22,866 inpatients were surveyed prospectively from January to April 2012 at the Peking Union Medical College Hospital. Only cutaneous ADRs induced by systemic drugs were considered. Fifty cases were confirmed as cutaneous ADRs, for an estimated incidence of 2.2 per 1000 during this period (95 % confidence interval 1.6-2.8). Cases of cutaneous ADRs comprised 69 % females, while 63 % of all inpatients were female (χ (2) = 0.641, P = 0.427). The department of infectious diseases was the most frequently involved department. Morbilliform exanthema (40 %) was the most frequent cutaneous ADR, followed by urticaria (23.1 %). Anti-infection drugs (36.9 %) caused most cases of cutaneous ADRs, followed by iodinated contrast media (ICM, 18.5 %) and non-steroidal anti-inflammatory drugs (NSAIDs, 18.5 %). The most frequently associated disorders were cancer (24 %), infection (22 %), cardiovascular and cerebrovascular diseases (20 %), and autoimmune diseases (18 %). In this first prospective study assessing the incidence of cutaneous ADRs in China, anti-infection drugs were the most commonly involved drugs, followed by ICM and NSAIDs. No evidence of increased cutaneous ADR incidence in AIDS or SLE patients was observed. Our findings indicate that cancer and its treatments were often related to cutaneous ADRs in China.

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Section: Discussionsupporting

confidence: 90%

“…Iodinated contrast media (ICM), used to facilitate radiographic imaging modalities since the 1950s [13], were the second most frequent medicines found to cause cutaneous ADRs in the present study. These findings are supported by Korean studies but not by those conducted in other countries [19].…”

Section: Discussionmentioning

confidence: 75%

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

et al. 2015

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“…Additionally, QDs have been shown to remain in major organs for months after injection producing immunogenic reactions in vivo [352][353][354][355]. Iodinated agents are also less than ideal because of their biological toxicity and short circulation time in vivo [356][357][358]. For example, Kim et al reported that when Ultravist, an iodine based contrast agent, was used in a rat model the circulation time was less than 10 min compared to that of 30 nm spherical Au nanoparticles which circulated in vivo for over 4 h [356].…”

Section: Imagingmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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“…Attenuation on CT scan may be influenced by the use of contrast agents. Intravascular iodinated contrast agents are frequently used for diverse diagnostic purposes (Pasternak & Williamson, 2012). After injection, the intravascular contrast agent mixes with blood and distributes into the interstitial space (Thomsen & Morcos, 2000;Fosbinder & Orth, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Because iodine absorbs radiation to a greater degree than soft tissue or vessels (Fosbinder & Orth, 2012) with a typical attenuation of about +130 HU , it allows better visualisation of soft tissue and vessels and thereby facilitates diagnosis (Fosbinder & Orth, 2012). The attenuation of the contrast agent depends on the number of iodine molecules present in the tissue to be imaged, which in its turn depends on perfusion of the tissue (Pasternak & Williamson, 2012). Presence of the iodinated contrast agent in skeletal muscleeither intravascular or interstitialmay lead to more radiation absorption by the muscle.…”

Section: Introductionmentioning

confidence: 99%

Skeletal muscle analyses: agreement between non‐contrast and contrast CT scan measurements of skeletal muscle area and mean muscle attenuation

Werf

Dekker

Meijerink

et al. 2017

Clin Physio Funct Imaging

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Low skeletal muscle area (SMA) and muscle radiation attenuation (MRA) have been associated with poor prognosis in various patient populations. Both noncontrast and contrast CT scans are used to determine SMA and MRA. The effect of the use of a contrast agent on SMA and MRA is unknown. Therefore, we investigated agreement between these two scan options. SMA and MRA of 41 healthy individuals were analysed on a paired non-contrast and contrast single CT scan, and agreement between paired scan results was assessed with use of Bland-Altman plots, intraclass correlation coefficients (ICCs), standard error of measurements (SEM) and smallest detectable differences at a 95% confidence level (SDD 95

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Clinical Pharmacology, Uses, and Adverse Reactions of Iodinated Contrast Agents: A Primer for the Non-radiologist

Cited by 158 publications

References 81 publications

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

Incidence of adverse cutaneous drug reactions in 22,866 Chinese inpatients: a prospective study

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Skeletal muscle analyses: agreement between non‐contrast and contrast CT scan measurements of skeletal muscle area and mean muscle attenuation

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