Clinical phenotypes of adult atopic dermatitis and related therapies

Patruno, Cataldo; Potestio, Luca; Napolitano, Maddalena

doi:10.1097/aci.0000000000000837

Cited by 48 publications

(42 citation statements)

References 82 publications

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“…64 The early onset in childhood, the chronicrelapsing course, the need for continuous monitoring of the disease severity, and the association with atopic comorbidities make AD an important global public health issue. [65][66][67][68][69] These concerns raised the need for new treatment strategies during the COVID-19 pandemic period, where face-to-face visits were limited.…”

Section: Teledermatology and Psoriasismentioning

confidence: 99%

The Role of Teledermatology During the COVID-19 Pandemic: A Narrative Review

Ruggiero¹,

Fabbrocini²,

Villani³

et al. 2022

CCID

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Teledermatology represented one of the most important and useful tools during the COVID-19 pandemic era. Indeed, due to the severe restriction, and to reduce the spread of the infection, different measures were applied among different countries and hospitals to ensure a continuity of care for patients. In this scenario, teledermatology played a central role, especially in the management of patients suffering from chronic inflammatory skin diseases. The aim of this narrative review is to describe the role of teledermatology during the COVID-19 pandemic to analyze main strengths and limitations of this tool, as well as to provide future perspectives in clinical applications.

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Section: Teledermatology and Psoriasismentioning

confidence: 99%

The Role of Teledermatology During the COVID-19 Pandemic: A Narrative Review

Ruggiero¹,

Fabbrocini²,

Villani³

et al. 2022

CCID

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“…[77][78][79][80][81][82][83] However, there is not a clear correlation with clinical phenotypes. 84 Moreover, undergoing treatment with dupilumab does not seem to prevent the possibility of a flare of the disease, even if its efficacy and safety have been largely demonstrated. 85,86 No data of atopic dermatitis worsening in patients undergoing treatment with janus kinase inhibitors are available.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature

Battista¹,

Marasca²,

Genco³

et al. 2022

CCID

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The outbreak of coronavirus disease 2019 represented a new worldwide challenge, strongly impacting on the global economy, overall health and lifestyle. Since then, several strategies have been adopted to contain the widespread of infection. Among these, vaccination is currently the most important measure to fight against the pandemic. However, several concerns such as slower-than-hoped-for rollout, the hurried approval with limited data, the mechanism of action (in particular mRNA-based), and the uncertain duration of protection they afforded were initially raised. Moreover, even if cutaneous reactions have been rarely reported in clinical trials, global mass vaccination showed several dermatologic reactions not initially recognized, leaving dermatologists to decide how to diagnose and treat them. In this scenario, dermatologists should be ready to promptly recognize these clinical manifestations. Thus, the aim of this manuscript is to review current literature on cutaneous reactions following COVID-19 vaccination, particularly inflammatory dermatological diseases, in order to help clinicians to better understand these dermatological conditions and to provide an extensive overview of all the vaccine-related skin manifestations.

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“…Fezakinumab, przeciwciało monoklonalne blokujące IL-22, może być odpowiedni dla pacjentów z ciężką postacią AZS, najlepiej z wysokim wyjściowym poziomem IL-22. U pacjentów z umiarkowanym AZS nie uzyskano znaczącej skuteczności [8,24]. Potencjalna dominacja Th17 w populacji azjatyckiej pozwoliłaby na opcję zastosowania leków biologicznych anty-IL-17 typowo zatwierdzonych dla łuszczycy [12,13,14].…”

Section: F Leczenie W Odniesieniu Do Fenotypówunclassified

Atopic dermatitis – clinical phenotypes and related therapeutic possibilities

GIEROBA

Gładysz

SZYDŁOWSKA

et al. 2022

J Educ Health Sport

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Introduction: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. It is characterized by damaged epidermal barrier, skin dysbiosis and pruritus. It affects up to 20% of the population of developed countries. AD represents a heterogeneous condition belonging to the spectrum of atopic diseases. It occurs in the form of multiple phenotypes with varied pathogenesis requiring different therapeutic strategies. Aim of the study: To summarize the current state of knowledge on AD phenotypes and related therapeutic options. Methods and materials: A review of the literature available in PudMed and Google Scholar databases was conducted. The following keywords were used: "atopic dermatitis", "atopic dermatitis phenotypes", "atopic dermatitis current treatment". Results: There are many phenotypes of AD. However, due to the lack of a consistent classification system, identifying phenotypes is greatly hindered. It is possible to use the division of phenotypes into groups based on age, lesion topography, lesion morphology and patient ethnicity. Various drugs are available for the treatment of AD, but therapeutic strategies for specific phenotypes are sparse and insufficiently understood due to the problem of identifying phenotypes and the complexity of the endotypes behind them. Treatment of AD is not currently based on phenotype-specific targeted therapy. Conclusion: Development of personalized therapy for the treatment of AD requires additional research using uniform definitions of phenotypes and endotypes. It is necessary to create a classification system for AD phenotypes.

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Clinical phenotypes of adult atopic dermatitis and related therapies

Cited by 48 publications

References 82 publications

The Role of Teledermatology During the COVID-19 Pandemic: A Narrative Review

The Role of Teledermatology During the COVID-19 Pandemic: A Narrative Review

Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature

Atopic dermatitis – clinical phenotypes and related therapeutic possibilities

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