The participants of the Electronic Collaboration working group of the 2010 Academic Emergency Medicine consensus conference developed recommendations and research questions for improving regional quality of care through the use of electronic collaboration. A writing group devised a working draft prior to the meeting and presented this to the breakout session at the consensus conference for input and approval. The recommendations include: 1) patient health information should be available electronically across the entire health care delivery system from the 9-1-1 call to the emergency department (ED) visit through hospitalization and outpatient care, 2) relevant patient health information should be shared electronically across the entire health care delivery system, 3) Web-based collaborative technologies should be employed to facilitate patient transfer and timely access to specialists, 4) personal health record adoption should be considered as a way to improve patient health, and 5) any comprehensive reform of regionalization in emergency care must include telemedicine. The workgroup emphasized the need for funding increases so that research in this new and exciting area can expand. ACADEMIC EMERGENCY MEDICINE 2010; 17:1312-1321 ª 2010 by the Society for Academic Emergency Medicine T he world of information technology is rapidly changing, yet changes in health care have been slow. 1-3 The science supporting how information technology will affect regionalization is sparse in many areas, although it is growing. The purpose of this article is to report on the efforts of the 2010 Academic Emergency Medicine consensus conference workgroup tasked with exploring the research agenda for how to improve regionalization through electronic collaboration. We decided to focus on the following broad topics: electronic health record (EHR) implementation, regional health information exchange (HIE), Web-based collaborative tools, personal health records, and tele-medicine. When considering EHRs, it is necessary to consider the nationwide status of emergency department (ED) EHR implementation. The 2003 survey by Pallin et al. 4 and the recent work of Landman et al. 5 suggest low levels of full implementation, although recent publications suggest both improved efficiencies and financial gain can be achieved with comprehensive implementation of fully integrated EHRs. 6,7 The question now is not if EDs will implement fully functioning EHRs, but when. The next wave of implementation work will involve ED EHR integration of prehospital data and should help answer whether capturing and sharing prehospital data improves the overall care of patients. While EDs implement EHRs, will currently available technology be employed in other realms to enhance regional networks of care? We already know that regional stroke centers, trauma centers, and heart centers can improve outcomes. 8-10 Perhaps simply sharing, comparing, and studying the protocols already in place that drive physician decision-making can affect care and quality across regions. T...