Clinical potential of boron neutron capture therapy for locally recurrent inoperable previously irradiated head and neck cancer

Urinary Proteomics Profiles Are Useful for Detection of Cancer Biomarkers and Changes Induced by Therapeutic Procedures

“…BNCT has already proven to be a promising tool in the treatment of a number of cancer, including head and neck squamous cell carcinoma (HNSCC) [4,5,6,7]. BNCT has been explored as an alternative therapy to the currently employed surgery, chemotherapy, or radiotherapy, bearing the advantages of less application (one or two doses) and the ability to maintain intact the oro-facial structures and functions [8].…”

Boron neutron capture therapy in clinical application:Progress and prospect

“…研究最终纳入30例复发无法手术的局部晚期头 颈部肿瘤患者接受BNCT治疗, 其中26例患者接受2次 . 有 研究纳入7项针对手术及常规放疗或放化疗后复发无 法手术的局部晚期头颈部肿瘤给予BNCT治疗的临床 研究(日本5项、芬兰1项和中国1项) [21] . Suzuki等人 照射野照射的平板(右前斜位、右后斜位、左前斜位 及左后斜位), 最终达到平均肺剂量为7.5 Gy-Eq, 肺肿 瘤的剂量达到8.3~26 Gy-Eq [32,33] .…”

Clinical Radiobiology of Fast Neutron Therapy: What Was Learnt?

“…The RBE issues within BNCT are further complicated by the dose being dependent on the concentration of the boron-containing compound, which is reflected in a compound biological effectiveness or CBE ( 45 ). Some pilot studies have shown promise in highly malignant brain tumours or for recurrent tumours, although in uncontrolled, highly selected patients ( 46 , 47 ), and the future prospects remain uncertain, although hospital-based accelerators for thermal neutron sources could reduce the inconvenient dependency on a nuclear reactor as a source ( 48 ). Further discussion is beyond the scope of this article.…”