Clinical Potentials of miR-576-3p, miR-613, NDRG2 and YKL40 in Colorectal Cancer Patients

Eldaly, Manal Nasreddin; Metwally, Fateheya M.; Shousha, Wafaa Gh.; El-Saiid, Abeer Salah; Ramadan, Shimaa Shawki

doi:10.31557/apjcp.2020.21.6.1689

Cited by 13 publications

(11 citation statements)

References 40 publications

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“…Accumulated evidence suggests that miR-613 is interrelated to various tumor genesis and development. For instance, miR-613 is lowly expressed in colorectal cancer and has diagnostic and prognostic functions in colorectal cancer [33]; miR-613 represses hepatocellular carcinoma cell dediferentiation through the SOX9 signaling, which provides novel therapeutic targets for hepatocellular carcinoma [34]. It has been authenticated that miR-613 initiates NSCLC cell cycle arrest via regulating CDK4 [35].…”

Section: Discussionmentioning

confidence: 99%

Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization

Yang

Zhou

et al. 2023

Journal of Oncology

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Background. Non-small cell lung cancer (NSCLC) is a crucial crux of cancer-related death, and M2 macrophage polarization facilitates NSCLC development. MicroRNA-613 (miR-613) is a tumor suppressor. This research aimed to clarify the miR-613 function in NSCLC and its impact on M2 macrophage polarization. Methods. miR-613 expressions in NSCLC tissues and cells were evaluated using quantitative real-time PCR. For miR-613 function in NSCLC, cell proliferation analysis, cell counting kit-8, flow cytometry, western blot, transwell, and wound-healing were conducted. Meanwhile, the miR-613 impact on M2 macrophage polarization was assessed by the NSCLC models. Results. miR-613 was lessened in NSCLC cells and tissues. It was corroborated that miR-613 overexpression retrained NSCLC cell proliferation, invasion, and migration but facilitated cell apoptosis. Moreover, miR-613 overexpression restrained NSCLC development by repressing M2 macrophage polarization. Conclusion. Tumor suppressor miR-613 ameliorated NSCLC by restraining M2 macrophage polarization.

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Section: Discussionmentioning

confidence: 99%

Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization

Yang

Zhou

et al. 2023

Journal of Oncology

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“…The clinical behaviour of CRC is a result of multi-layered interactions, and genetic changes in oncogenes and/or oncosuppressor genes are the most important drivers of tumorigenesis and cancer progression (26). MiRNAs are novel biomarkers that can be used for the early diagnosis, prognostic assessment, and treatment of CRC (27). In this study, we investigated the relationship between miR-492 and the prognosis of patients with CRC using the GEO database and examined the effects of miR-492 on the growth, migration, and invasion of CRC cells through a series of in vitro cell experiments.…”

Section: Discussionmentioning

confidence: 99%

Investigating whether microRNA-492 promotes colorectal cancer cell growth, migration, and invasion by targeting neuronal pentraxin 1

Zhang,

Yu,

Shao

et al. 2023

Preprint

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Background Colorectal cancer (CRC) is one of the most common cancer types affecting both men and women. MicroRNA-492 (miR-492) plays an important role in the development of various malignant tumours; however, its specific role and related mechanisms in CRC development remain unclear. Hence, we aimed to explore the relationship between miR-492 and the prognosis of CRC patients and the specific mechanisms involved in the development of CRC. Methods The GSE29622 dataset was downloaded from the Gene Expression Omnibus database to analyse the relationship between the miR-492 expression level and the overall survival of patients with CRC. Forty-four pairs of primary CRC tissues and paired normal tissues were collected. The relationship between the miR-492 expression level and clinicopathological parameters of patients with CRC was analysed using a statistical method. MiRNA quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect miR-492 expression levels in CRC tissues and cell lines. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and colony formation assays were performed to assess cell growth and proliferation, respectively. Transwell assays were performed to analyse the migration and invasion potential of CRC cells. The interaction between miR-492 and three prime untranslated regions (3′-UTRs) of neuronal pentraxin 1 (NPTX1) was evaluated using a luciferase reporter assay. The expression of NPTX1 in CRC tissues and cells was detected by qRT-PCR. Results MiR-492 could recognise the 3′-UTR of NPTX1 mRNA and directly target and regulate NPTX1 expression, thereby promoting the growth, migration, and invasion of CRC cells. Conclusions The ability to mediate the biological behaviour of CRC by targeting NPTX1 makes miR-492 a potential prognostic marker and therapeutic target for CRC.

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“…The expression of miR-375 was also downregulated in leukemic cell lines and primary AML blasts compared to normal controls, and its overexpression decreased proliferation and colony formation, reduced xenograft tumor size and prolonged the survival time in a leukemia xenograft mouse model [ 41 ]. MiR-576-3p was shown to be downregulated in colorectal [ 42 ] and bladder cancer [ 43 ], to inhibit the migration and invasion of lung adenocarcinoma [ 44 ] and to significantly inhibit the migration and pro-angiogenic abilities of glioma cells under hypoxic conditions [ 45 ]. Additionally, miR-597 inhibits breast and colon cancer cell proliferation, migration and invasion [ 46 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Acute Myeloid Leukemia Bone Marrow Circulating MicroRNAs

Agha

Rouas

Najar

et al. 2020

IJMS

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Background: In addition to their roles in different biological processes, microRNAs in the tumor microenvironment appear to be potential diagnostic and prognostic biomarkers for various malignant diseases, including acute myeloid leukemia (AML). To date, no screening of circulating miRNAs has been carried out in the bone marrow compartment of AML. Accordingly, we investigated the circulating miRNA profile in AML bone marrow at diagnosis (AMLD) and first complete remission post treatment (AMLPT) in comparison to healthy donors (HD). Methods: Circulating miRNAs were isolated from AML bone marrow aspirations, and a low-density TaqMan miRNA array was performed to identify deregulated miRNAs followed by quantitative RT-PCR to validate the results. Bioinformatic analysis was conducted to evaluate the diagnostic and prognostic accuracy of the highly and significantly identified deregulated miRNA(s) as potential candidate biomarker(s). Results: We found several deregulated miRNAs between the AMLD vs. HD vs. AMLPT groups, which were involved in tumor progression and immune suppression pathways. We also identified significant diagnostic and prognostic signatures with the ability to predict AML patient treatment response. Conclusions: This study provides a possible role of enriched circulating bone marrow miRNAs in the initiation and progression of AML and highlights new markers for prognosis and treatment monitoring.

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Clinical Potentials of miR-576-3p, miR-613, NDRG2 and YKL40 in Colorectal Cancer Patients

Cited by 13 publications

References 40 publications

Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization

Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization

Investigating whether microRNA-492 promotes colorectal cancer cell growth, migration, and invasion by targeting neuronal pentraxin 1

Identification of Acute Myeloid Leukemia Bone Marrow Circulating MicroRNAs

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