Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version

Usui, Joichi; Yamagata, Kunihiro; Imai, Eri; Okuyama, Hiroshi; Kajiyama, Hiroshi; Kanamori, Hiroshi; Kaneko, Shuzo; Kono, Emiko; Sakai, Yukinao; Sakai, Norihiko; Sakamaki, Yuichi; Taniguchi, Yoshinori; Nakai, Kentaro; Nishiwaki, Hiroki; Hirata, Sumio; Yamaya, Hideki; Tsuruoka, Shuichi; Terada, Yoshio; Yokoyama, Hitoshi; Wada, Takashi; Narita, Ichiei

doi:10.1007/s10157-016-1334-0

Cited by 24 publications

(28 citation statements)

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“…ey can also regulate immunity by inhibiting T cell proliferation and regulating B lymphocytes. (4) In this study, the most common drugs causing liver and/or kidney injury were antineoplastic drugs, antibiotics, traditional Chinese medicines, lipidlowering drugs, nonsteroidal anti-inflammatory drugs, antituberculosis drugs [24], antithyroid drugs, hormones, antiviral drugs, and sedative and psychotropic drugs. Antineoplastic drugs [25], antibiotics, and nonsteroidal anti-inflammatory drugs are more likely to lead to kidney injury, while traditional Chinese medicines and lipid-lowering drugs are more likely to lead to liver injury.…”

Section: Discussionmentioning

confidence: 89%

“…e inclusion criteria for the research subjects were as follows: (1) drug exposure history within 3 months; (2) clinical chemistry parameters [2,3] that fit any one of the following criteria: "more than or equal to fivefold elevation above the upper limit of normal (ULN) for alanine aminotransferase (ALT), more than or equal to twofold elevation above the ULN for alkaline phosphatase (ALP), or more than or equal to threefold elevation in ALT concentration and simultaneous elevation of bilirubin concentration exceeding 2× ULN"; and (3) liver function improved rapidly after withdrawal. e exclusion criteria were as follows: (1) liver injury caused by other diseases; (2) primary hepatobiliary diseases; (3) serious infections, shock, pulmonary insufficiency, heart failure, and other diseases that can cause hypoxic injury of whole body tissues; (4) age < 18 years; and (5) incomplete medical records.…”

Section: Research Subjects From 2008 To 2018 Patients Withmentioning

confidence: 99%

“…e diagnosis of drug-induced kidney injury was based on the 2016 clinical guidelines in Japan [4]. e inclusion criteria for this study were as follows: (1) patients with acute kidney injury (AKI) with a drug exposure history within 3 months, (2) an abnormal estimated glomerular filtration rate (eGFR) based on serum creatinine using the Modification of Diet in Renal Disease (MDRD) formula developed by the simplified American Kidney Disease Diet Improvement Research Group:…”

Section: Research Subjects From 2008 To 2018 Patients Withmentioning

confidence: 99%

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Clinical Characteristics of 162 Patients with Drug-Induced Liver and/or Kidney Injury

Wang

Chen

2020

BioMed Research International

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Context. Drug-induced liver and kidney injuries are the most common adverse drug reactions in the clinic, and they have similar pathogeneses. Aims. To analyze the clinical characteristics of patients with drug-induced liver and/or kidney injury. Settings and Design. This was a retrospective study. Methods and Materials. We analyzed data from 162 patients with drug-induced liver and/or kidney injury from 2008 to 2018 at the Chinese Rocket Force Characteristic Medical Center. Univariate and multivariate logistic analyses were performed on the drugs used, sex, age, weight, complications, and laboratory test results. Statistical analysis was performed using SPSS 25.0 statistical software. Results. (1) The most common drugs causing organ injury in this study were antineoplastic drugs, antibiotics, traditional Chinese medicine, lipid-lowering drugs, and nonsteroidal anti-inflammatory drugs. (2) Among 22 patients with drug-induced liver and kidney injuries, 68.18% had a hepatocellular pattern, 13.64% had a mixed pattern, and 18.18% had a cholestatic pattern. Among the three groups, the P value for creatinine was 0.002. (3) The P value for urinary protein between the isolated kidney injury group and the liver and kidney injury group was 0.028. (4) Multivariate analysis showed that, among the drug-induced renal injury patients and all injury patients, those with a higher neutrophil percentage had a lower risk of liver injury (OR = 0.574, 95% CI: 0.390–0.846; OR = 0.545, 95% CI: 0.396–0.749). Conclusions. (1) The serum creatinine level was higher in liver injury patients with the cholestatic pattern than in those with the hepatocellular or mixed pattern. (2) There was a significant difference in urinary protein between the isolated kidney and the liver and kidney injury groups. (3) Among patients with drug-induced organ injury, those with a higher neutrophils percentage had a lower risk of liver injury.

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Section: Discussionmentioning

confidence: 89%

Section: Research Subjects From 2008 To 2018 Patients Withmentioning

confidence: 99%

Section: Research Subjects From 2008 To 2018 Patients Withmentioning

confidence: 99%

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Clinical Characteristics of 162 Patients with Drug-Induced Liver and/or Kidney Injury

Wang

Chen

2020

BioMed Research International

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“…Other than VCM, there were many other drugs that could potentially cause AKI. 9,10) However, in this study, we consider that AKI onset was associated with empirical VCM therapy because SCr levels normalized after discontinuation of only VCM. We found that AKI had an incidence rate of 11.4% during empirical VCM treatment.…”

Section: Discussionmentioning

confidence: 96%

“…Moreover, Cases 1-4 received no high-risk AKI drugs such as antirheumatics, immunosuppressives, anticancer drugs, non-steroidal antiinflammatories, and acyclovir. 9,10) In addition, there were no patients with adverse events such as VIII cranial nerve neuropathy, pancytopenia, and liver dysfunction induced by empirical VCM treatment. Table 3 shows the results of cerebrospinal fluid cultures performed before the administration of the first dose of the antimicrobial drug.…”

Section: Patient Demographicsmentioning

confidence: 94%

Influence of Empirical Therapy Utilizing Vancomycin in Patients with Suspected Bacterial Meningitis: A Single-Center Retrospective Study

et al. 2020

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The incidence rate of bacterial meningitis caused by methicillin-resistant staphylococci is lower than that of bacterial meningitis caused by other gram-positive bacteria. However, considering the high mortality rate of staphylococcal infections, empirical vancomycin (VCM) therapy is often used. On the other hand, VCM is known to affect renal function. Therefore, it is necessary to understand the risks of empirical VCM therapy in patients with suspected bacterial meningitis. We aimed to investigate the risk of acute kidney injury (AKI) associated with empirical VCM therapy in patients with suspected bacterial meningitis. We reviewed the records of 35 suspected bacterial meningitis patients treated with empirical VCM therapy at Fukuoka University Hospital between 2011 and 2017. The incidence rate of AKI associated with empirical VCM therapy was evaluated based on Kidney Disease: Improving Global Outcome criteria. The patients were aged 65.0 (44.0-75.0) years, and had various underlying diseases such as subarachnoid hemorrhage, cerebral hemorrhage, other diseases of the head and community-acquired infection. Methicillin-resistant staphylococci were detected in only 3 patients. In 4 patients with negative culture results, empirical VCM therapy was continued for more than 1 week; this resulted in AKI. The incidence rate of AKI associated with empirical VCM therapy was 11.4%. For patients with suspected bacterial meningitis requiring empirical VCM therapy, it is important to check the necessity of VCM by bacterial culture tests and ensure the safety by monitoring blood concentrations in order to avoid the risk of AKI.

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Differences in the performance of adjuvant chemotherapy between hemodialysis and nonhemodialysis patients

2022

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Background:The survival of hemodialysis (HD) patients with cancer is poor, which may be caused by undertreatment due to renal dysfunction. Particularly, adjuvant chemotherapy after surgery may be considered optional because of its preventive nature. This study investigated the current frequency of administration of adjuvant chemotherapy to HD patients compared with non-HD patients in Japan. Methods:We used data from the Hospital-Based Cancer Registries national database linked to health services utilization data to analyze cases of newly diagnosed colon cancer, gastric cancer, breast cancer, and non-small cell lung cancer (NSCLC) at the stages where adjuvant chemotherapy is generally required.We compared the performance rate of adjuvant chemotherapy and the adjuvant chemotherapy regimens between HD and non-HD patients from October 2011 to December 2017.Results: Of the 99,761 patients who underwent curative surgery, 1207 (1%) were HD patients. HD patients received adjuvant chemotherapy less frequently than non-HD patients (24% vs. 63%, p < 0.001). After adjusting for potential confounders, HD remained negatively related to adjuvant chemotherapy administration for all four cancer types. Among all patients who received adjuvant chemotherapy 0(N = 61,873), HD patients were less likely to receive standard regimens and chemotherapy requiring dose adjustment than non-HD patients (88% vs. 95%, p < 0.001 and 92% vs. 98%, p < 0.001, respectively). This trend was particularly pronounced among patients with gastric cancer.Conclusions: HD patients were less likely to receive adjuvant chemotherapy with standard regimens than non-HD patients.

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Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version

Cited by 24 publications

References 1 publication

Clinical Characteristics of 162 Patients with Drug-Induced Liver and/or Kidney Injury

Clinical Characteristics of 162 Patients with Drug-Induced Liver and/or Kidney Injury

Influence of Empirical Therapy Utilizing Vancomycin in Patients with Suspected Bacterial Meningitis: A Single-Center Retrospective Study

Differences in the performance of adjuvant chemotherapy between hemodialysis and nonhemodialysis patients

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