Clinical Practice Guideline for the Management of Chronic Kidney Disease in Patients Infected With HIV: 2014 Update by the HIV Medicine Association of the Infectious Diseases Society of America

Lucas, Gregory M.; Ross, Michael J.; Stock, Peter G.; Shlipak, Michael G.; Wyatt, Christina M.; Gupta, Samir K.; Atta, Mohamed G.; Wools‐Kaloustian, Kara; Pham, Paul A.; Bruggeman, Leslie A.; Lennox, Jeffrey L.; Ray, Patricio E.; Kalayjian, Robert C.

doi:10.1093/cid/ciu617

Cited by 265 publications

(288 citation statements)

References 413 publications

(515 reference statements)

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“…When age was analyzed as a dichotomous variable by other authors, patients > 50 years presented a relative risk of 2.0 for progression to ESRD or an eGFR < 15 mL/min compared to patients < 30 years. 16 A CD4 lymphocyte count < 400 cells/μL was another factor associated with CKD (defined by GFR or albuminuria) in our population. This has been consistently demonstrated by other investigators, reporting a relative risk range for CKD (defined by GFR or albuminuria) from 1.1 to 1.25 for each decrease of 100 cells/μL or from 1.4 to 2.2 for patients with CD4 < 200 vs. > 201 cells/μL.…”

mentioning

confidence: 61%

Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients

et al. 2019

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Fatores epidemiológicos, clínicos e laboratoriais associados à doença renal crônica em pacientes mexicanos infectados pelo HIV Objetivo: Determinar a prevalência de doença renal crônica (DRC) e os fatores epidemiológicos, clínicos e laboratoriais associados à DRC em pacientes mexicanos infectados pelo HIV. Métodos: Estudo transversal. Incluímos 274 pacientes com HIV/AIDS. A DRC foi definida pela taxa de filtração glomerular estimada (TFGe < 60 mL/min/1,73 m 2 , avaliada pelo CKD-EPI) e pelos critérios de albuminúria das diretrizes do KDIGO. As características clínicas, epidemiológicas e laboratoriais foram comparadas entre pacientes com e sem DRC. Os fatores associados à DRC foram avaliados por análise de regressão logística. Resultados: A média da idade foi de 41 ± 11 anos e 72,3% dos pacientes eram homens. A prevalência global de DRC foi de 11,7% (n = 32); 7,2% (n = 20) foram definidos pelo critério TFGe; 7,6% (n = 21), pelo critério da albuminú-ria; e 3,2% (n = 9), pelos dois critérios para DRC. Os estágios mais frequentemente observados da DRC foram o estágio KDIGO G3A1 com 4,7% (n = 13); estágio KDIGO G1A2 com 3,6% (n = 10) e estágio KDIGO G3A2 com 1,7% (n = 5). Os fatores associados à DRC foram o uso de abacavir/lamivudina (OR 3,2; IC95% 1,1-8,9; p = 0,03), contagem de linfócitos CD4 < 400 células/ μL (OR 2,6; 95% 1,03-6,4, p = 0,04), idade (OR 1,1; IC95% 1,04-1,2, p = 0,001) e albuminúria (OR 19,98; IC95%: 5,5-72,2; p < 0,001). Conclusões: A DRC foi uma complicação frequente em pacientes infectados pelo HIV. Esses achados confirmam a importância do rastreamento e da detecção precoce da DRC, bem como a importância de identificar e tratar os fatores de risco tradicionais e não tradicionais associados à DRC. ResumoPalavras-chave: Insuficiência Renal Crôni-ca; HIV; Insuficiência Renal. Aim:To determine the prevalence of chronic kidney disease (CKD) and the epidemiological, clinical, and laboratory factors associated with CKD in Mexican HIV-infected patients. Methods: Crosssectional study. We included 274 patients with HIV/AIDS. CKD was defined by the estimated glomerular filtration rate (eGFR < 60 mL/min/1.73 m 2 assessed by CKD-EPI) and albuminuria criteria from KDIGO guidelines. Clinical, epidemiological, and laboratory characteristics were compared between patients with and without CKD. The factors associated with CKD were assessed by logistic regression analysis. Results: The mean age was 41±11 years, and 72.3% of the patients were men. The global prevalence of CKD was 11.7% (n = 32); 7.2% (n = 20) were defined by eGFR criterion; 7.6% (n = 21), by the albuminuria criterion; and 3.2% (n = 9), by both CKD criteria. The most frequently observed stages of CKD were KDIGO G3A1 stage with 4.7% (n = 13), KDIGO G1A2 stage with 3.6% (n = 10) and KDIGO G3A2 stage with 1.7% (n = 5). The factors associated with CKD were use of abacavir/lamivudine (OR 3.2; 95% CI 1.1-8.9; p = 0.03), a CD4 lymphocyte count < 400 cells/μL (OR 2.6; 95% 1.03-6.4, p = 0.04), age (OR 1.1; 95% CI 1.04-1.2, p = 0.001) and albuminuria (OR 19.98...

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confidence: 61%

Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients

et al. 2019

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“…Recent IDSA guidelines have been the first to strongly recommend the use of the percentage of eGFR decline from baseline (> 25%) with eGFR (< 60 ml/min/1.73 m 2 ) to substitute alternative drugs for TDF, although with a low level of evidence [28]. In our study, the best diagnostic performance of CRDRF using eGFR or creatinine was obtained with the percentage of variation of eGFR from baseline (CKD-EPI) at month 30.…”

Section: Discussionmentioning

confidence: 75%

Long-term comparative and prospective cohort study of renal function in patients with HIV infection treated with tenofovir disoproxil fumarate

Calle¹,

Pulido²,

Sánchez-Conde³

et al. 2017

HIV & AIDS Review

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“…26 Risk factors for kidney injury that are specific for HIV include ART-related nephrotoxicities, HCV co-infection, lower CD4+ cell count, and higher HIV RNA levels. 27 HIV medications that are particularly associated with kidney injury include specific PIs (i.e., indinavir, lopinavir/ritonavir and atazanavir) and tenofovir disoproxil fumarate.…”

Section: Hiv-associated Non-aids Complications (Hana)mentioning

confidence: 99%

“…HIV-infected African-Americans are at particular risk for developing advanced kidney disease due to their susceptibility to HIV-related nephropathy. 26 . When choosing combination ART for patients with chronic kidney disease, use of the older formulation of tenofovir (tenofovir disoproxil fumarate), especially in combination with a PI, should be avoided if possible.…”

Section: Hiv-associated Non-aids Complications (Hana)mentioning

confidence: 99%

Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome in Older Adults

Scott

Goetz

2016

Clinics in Geriatric Medicine

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Clinical Practice Guideline for the Management of Chronic Kidney Disease in Patients Infected With HIV: 2014 Update by the HIV Medicine Association of the Infectious Diseases Society of America

Cited by 265 publications

References 413 publications

Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients

Epidemiological, clinical, and laboratory factors associated with chronic kidney disease in Mexican HIV-infected patients

Long-term comparative and prospective cohort study of renal function in patients with HIV infection treated with tenofovir disoproxil fumarate

Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome in Older Adults

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