Clinical Practice Guideline for the Treatment of Intrinsic Circadian Rhythm Sleep-Wake Disorders: Advanced Sleep-Wake Phase Disorder (ASWPD), Delayed Sleep-Wake Phase Disorder (DSWPD), Non-24-Hour Sleep-Wake Rhythm Disorder (N24SWD), and Irregular Sleep-Wake Rhythm Disorder (ISWRD). An Update for 2015

Auger, R. Robert; Burgess, Helen J.; Emens, Jonathan S.; Deriy, Ludmila V.; Thomas, Sherene M.; Sharkey, Katherine M.

doi:10.5664/jcsm.5100

Cited by 349 publications

(229 citation statements)

References 188 publications

(259 reference statements)

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“…Polysomnography (PSG) is the gold standard diagnostic tool for evaluating OSAS, but only a small percentage of people at risk for OSAS have access to PSG, and using PSG in elderly populations with multiple comorbidities may be difficult [8]. Treatment options are similar for younger and older patients, as recommended by the American Academy of Sleep Medicine (AASM) [9].…”

Section: Introductionmentioning

confidence: 99%

Results of Polysomnographies and Treatment Strategies in Elderly Patients with Symptoms of Obstructive Sleep Apnea Syndrome

Balcan

Uğurlu

2017

Turk Thorac J

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OBJECTIVES:In this study, we evaluated data regarding the management of geriatric patients with symptoms of obstructive sleep apnea syndrome (age, >65 years) who were admitted to our sleep clinic. MATERIAL AND METHODS:Symptoms and sleep data of the patients were retrospectively evaluated, and the patients were reevaluated after treatment. RESULTS:A total of 85 patients with a median age of 69 years were included. Snoring and fatigue were the most common symptoms. Cardiovascular diseases were the most frequently listed comorbidity. The median Epworth sleepiness scale was 10, and based on Berlin sleep questionnaire findings, 63.5% of the participants were in the high-risk group. Eighty-seven percent were diagnosed with obstructive sleep apnea (2/3 of them were positional), and moderate-to-severe obstructive sleep apnea was observed more in women than in men. Only one patient was diagnosed with central sleep apnea. There were positive and linear correlations between increased age and the apnea-hypopnea index, arousal index, Epworth sleepiness scale, and being in a high-risk group according to the Berlin sleep scale; however, there was no correlation between increased age and the number of hypopnea and apnea events. There were also positive and linear correlations between the apnea-hypopnea index and the Epworth sleepiness scale, being in a high-risk group according to the Berlin sleep questionnaire, an increased number of known medical conditions, and increased body mass index. We were able to contact 72 of the 85 patients via phone calls. Patients who adjusted to treatment had positive feedbacks. CONCLUSION:Sleep disorders are observed more in the elderly, and an increasing age is an independent factor for sleep disorders. Besides the usual signs and symptoms of sleep disorders, it should be considered in elderly who have cognitive dysfunction and dementia. KEYWORDS: Elderly, polysomnography, obstructive sleep apnea INTRODUCTIONThe proportion of elderly people (age, >65 years) has been increasing, particularly in developing countries. The World Health Organization has estimated that the population of people aged >65 years will be 1.5 billion by 2050 [1]. Although some people age without having any serious illnesses, some elderly might have "pathological aging" with significant comorbidities that lead to functional impairment [2]. One way or another, the elderly may complain of changes in sleep habits such as difficulty falling asleep and maintaining sleep, with frequent nocturnal awakenings and early morning awakening; thus, sleep gets more fragmented and consequently lighter [3]. Because of the changes in sleep architecture or physiological and/or pathological changes owing to aging, elderly people may report increased daytime sleepiness and fatigue as well as concentration and memory problems [4]. These symptoms can also occur because of obstructive sleep apnea syndrome (OSAS), which is characterized by nocturnal episodes of upper airway obstruction, sleep fragmentations, and hypoxemia [5]. These symptoms might ...

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Section: Introductionmentioning

confidence: 99%

Results of Polysomnographies and Treatment Strategies in Elderly Patients with Symptoms of Obstructive Sleep Apnea Syndrome

Balcan

Uğurlu

2017

Turk Thorac J

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“…Often, the adolescent prefers to stay up later during the night and has difficulty waking up in the morning to meet societal expectations. Accompanying mood changes may be misdiagnosed as depression [8][9][10]. Unlike adults with sleep maintenance insomnia, these adolescents typically are able to sleep through the night once they manage to fall asleep.…”

Section: Age-related Manifestations Of Insomniamentioning

confidence: 99%

Pharmacotherapy of Insomnia in Children

Pelayo

Huseni

2016

Curr Sleep Medicine Rep

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Insomnia is defined as the inability to fall asleep and/or the inability to maintain sleep to the point that it has a negative impact on time awake. Insomnia in adults may lead to daytime fatigue and sleepiness but in children, the lack of quality sleep may lead to daytime behavioral problems such as hyperactivity and academic difficulty. The pharmacological treatment of insomnia in children is a challenging problem for clinicians since there is paucity of Food and Drug Administration (FDA) approved. Parents often seek medical attention for their children when their own or other members of the family's sleep schedule has been disrupted. The clinician has to take into account the entire family when evaluating a child and making therapeutic recommendations. When evaluating a child with insomnia, it is not only important to take a thorough history of the child's sleep schedule but it also involves getting a detailed evaluation of the other family member's sleep history. The pharmacological management of insomnia is dependent on the child's age. The primary healthcare physician may have limited training in pediatric sleep disorders. Although the mainstay treatment for insomnia in children is behavioral therapy, in this chapter, we will provide a review of the medications that may be used as an adjunct treatment for pediatric insomnia.

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“…Very high doses (≥ 10 mg) should be avoided to prevent "spilling over" onto the delay portion of the melatonin phase response curve and thus reduce its resetting effects. 7 The 2015 American Academy of Sleep Medicine (AASM) practice guidelines for the treatment of circadian rhythm sleep-wake disorders 8 recommend strategically timed melatonin for the treatment of DSWPD in adults, children and adolescents with or without psychiatric comorbidities, although the available evidence is weak (owing to the low number of high-quality studies).…”

mentioning

confidence: 99%

“…At high doses (≤ 10 mg), headaches, somnolence, hypotension, hypertension and alopecia have been reported. 8 Impaired glucose tolerance was also recently linked to melatonin administration. Caution is recommended for the use of melatonin in children, adolescents, women of reproductive age, patients with depression or epilepsy and patients on warfarin treatment.…”

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confidence: 99%

Treating delayed sleep–wake phase disorder in young adults

Boivin

2017

JPN

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Cited by 349 publications

References 188 publications

Results of Polysomnographies and Treatment Strategies in Elderly Patients with Symptoms of Obstructive Sleep Apnea Syndrome

Results of Polysomnographies and Treatment Strategies in Elderly Patients with Symptoms of Obstructive Sleep Apnea Syndrome

Pharmacotherapy of Insomnia in Children

Treating delayed sleep–wake phase disorder in young adults

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