Clinical Practice Guidelines for Liver Transplantation in Saudi Arabia

Abaalkhail, Faisal; Sebayel, Mohammed I. Al; Shagrani, Mohammed; O'Hali, Wael; AlMasri, Nasser; Alalwan, Abdullah; Alghamdi, Mohammed; Al-Bahili, Hamad; Alqahtani, Mohammed Saad; Alabbad, Saleh; Al–Hamoudi, Waleed; Alqahtani, Saleh

doi:10.15537/smj.2021.42.9.20210126

Cited by 6 publications

(4 citation statements)

References 328 publications

(599 reference statements)

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“…Within the Kingdom of Saudi Arabia (KSA), four centers offer LTs, and all four centers perform LDLTs, while only three perform DDLTs [37]. Each center that performs LTs has its own LT waiting list, with no national organ transplantation list [38].…”

Section: Kingdom Of Saudi Arabiamentioning

confidence: 99%

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Approach to Liver Transplantation: Is There a Difference between East and West?

Ozturk,

Bartosek,

Toruner

et al. 2024

JCM

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Liver transplantation (LT) remains the only curative treatment for end-stage liver disease as well as acute liver failure. With the exponential increase in organ demand due to the increasing incidence and prevalence of liver diseases, the need to overcome the supply and demand mismatch has arisen. In this review, we discuss the current universal status of LT, emphasizing various LT practices worldwide.

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Section: Kingdom Of Saudi Arabiamentioning

confidence: 99%

“…The Saudi Center for Organ Transplantation oversees and manages the donation process while collaborating with individual centers [39]. Although HCV is the most common indication for LT, the proportion of patients with MASH is increasing [37].…”

Section: Kingdom Of Saudi Arabiamentioning

confidence: 99%

Approach to Liver Transplantation: Is There a Difference between East and West?

Ozturk,

Bartosek,

Toruner

et al. 2024

JCM

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“…Fever is not always present due to the degree of immunosuppression. Therefore, clinical history and a complete physical examination, in addition to complementary exams, are essential in the evaluation of the transplant patient with any symptom without an apparent cause, as it may be because of an infectious condition (Abaalkhail et al, 2021).…”

Section: Monitoring Msud After Ltmentioning

confidence: 99%

Treatment of maple syrup urine disease: Benefits, risks, and challenges of liver transplantation

Deon,

Guerreiro,

Girardi

et al. 2023

Intl J of Devlp Neuroscience

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Maple syrup urine disease (MSUD) is caused by a deficiency in the activity of the branched‐chain α‐ketoacid dehydrogenase (BCKD) complex, promoting the accumulation of the branched‐chain amino acids (BCAA) leucine, isoleucine, and valine, as well as their respective α‐keto acids. MSUD is an autosomal recessive hereditary metabolic disorder characterized by ketoacidosis, ataxia, coma, and mental and psychomotor retardation. The mechanisms involved in the brain damage caused by MSUD are not fully understood. Early diagnosis and treatment, as well as proper control of metabolic decompensation crises, are crucial for patients' survival and for a better prognosis. The recommended treatment consists of a high‐calorie diet with restricted protein intake and specific formulas containing essential amino acids, except those accumulated in MSUD. This treatment will be maintained throughout life, being adjusted according to the patients' nutritional needs and BCAA concentration. Because dietary treatment may not be sufficient to prevent neurological damage in MSUD patients, other therapeutic strategies have been studied, including liver transplantation. With transplantation, it is possible to obtain an increase of about 10% of the normal BCKD in the body, an amount sufficient to maintain amino acid homeostasis and reduce metabolic decompensation crises. However, the experience related to this practice is very limited when considering the shortage of liver for transplantation and the risks related to the surgical procedure and immunosuppression. Thus, the purpose of this review is to survey the benefits, risks, and challenges of liver transplantation in the treatment of MSUD.

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“…Thus, a personalized therapy for HCC recurrence post-LT was recommended with no evidence supporting the use of sorafenib in patients with disseminated HCC recurrence. 77 The differences in outcomes among HCC patients who received sorafenib are often associated with their underlying hepatitis virus etiology at presentation. 46,[78][79][80] Our survey results showed that sorafenib was prescribed to only a quarter of patients ineligible for atezolizumab plus bevacizumab (Figure 5C).…”

mentioning

confidence: 99%

Treatment Patterns and Recommendations for Improving the Management of Hepatocellular Carcinoma in Saudi Arabia

Alolyan,

Alshammari,

Arabi

et al. 2024

JHC

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Hepatocellular carcinoma (HCC) is the sixth most common type of cancer in the world associated with high morbidity and mortality. Despite being a significant healthcare burden there is limited information on the unmet needs and current treatment practices for intermediate and advanced-stage HCC in Saudi Arabia. This article analyzes the gaps and provides expert consensus on the management strategies for unresectable HCC in Saudi Arabia. A pre-meeting online questionnaire, comprising 20 objective questions about the treatment landscape and diagnosis of HCC in Saudi Arabia, was distributed to experts in the field of HCC management. An advisory board meeting including a panel of 13 experts was held in September 2022 where the responses to the survey questionnaire were reviewed and discussed. The survey results and experts’ discussion highlighted the growing incidence of liver cancer in Saudi Arabia. HCC comprised the majority of all liver cancer cases due to rising rates of chronic viral infections and lifestyle-related risk factors. Most physicians in Saudi Arabia follow the Barcelona Clinic Liver Cancer guidelines as a prognostic tool for the detection and staging of patients with HCC. Most of the patients with HCC in Saudi Arabia are diagnosed in the intermediate or advanced stages with poor prognoses and limited therapeutic options. Establishing evidence-based surveillance techniques, a multidisciplinary approach to diagnosis, and better accessibility of treatment options is vital for the management of HCC in Saudi Arabia.

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Clinical Practice Guidelines for Liver Transplantation in Saudi Arabia

Cited by 6 publications

References 328 publications

Approach to Liver Transplantation: Is There a Difference between East and West?

Approach to Liver Transplantation: Is There a Difference between East and West?

Treatment of maple syrup urine disease: Benefits, risks, and challenges of liver transplantation

Treatment Patterns and Recommendations for Improving the Management of Hepatocellular Carcinoma in Saudi Arabia

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