Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in Turkey

Uzun, Soner; Gürel, Mehmet Salih; Durdu, Murat; Akyol, Melih; Karaman, Bilge Fettahlıoğlu; Aksoy, Mustafa; Aytekin, Sema; Borlu, Murat; Doğan, Esra; Doğramacı, Çiğdem Asena; Kapıcıoğlu, Yelda; Akman-Karakaş, Ayşe; Kaya, Tamer İrfan; Mülayim, Mehmet Kamil; Özbel, Yusuf; Töz, Seray; Özgöztaşı, Orhan; Yeşilova, Yavuz; Harman, Mehmet

doi:10.1111/ijd.14002

Cited by 48 publications

(89 citation statements)

References 43 publications

(112 reference statements)

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“…Intralesional antimone therapy is a treatment option which enables good cosmetic results without any significant side effect and with low risk of relapse. 15,16 Besides these, there are also other several physical treatments among the local treatment options of which the most common one is cryotherapy. 9,16 We used either IL antimony compounds or cryotherapy in our patients.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 Besides these, there are also other several physical treatments among the local treatment options of which the most common one is cryotherapy. 9,16 We used either IL antimony compounds or cryotherapy in our patients. The lesions of the patients, treated with the IL injections, recovered faster, with fewer treatment courses and better cosmetic results when compared with the cryotherapy group.…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Leishmaniasis: Evaluation of 117 Syrian Immigrants

Karaosmanoğlu¹,

Şahin²,

Vahaboğlu³

et al. 2019

Turkiye Klinikleri J Med Sci

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160 utaneous leishmaniasis (CL) is a skin disease which is caused by the protozoan parasites of the genus Leishmania. It causes lesions mostly in the skin and sometimes in the mucosa and heals leaving atrophic scars. 1 As it is known, a civil war started in Syria in 2011 which caused migration of a huge amount of people to neighboring countries. Approximately 3 million of these immigrants migrated to Turkey. 2 Cutaneous Leishmaniasis: Evaluation of 117 Syrian Immigrants A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Cutaneous leishmaniasis (CL), which presents with nodulo-ulcerative lesions in the skin, is an endemic disease in Syria and in some of the regions of Turkey. The aim of this study was to evaluate the demographic and clinical characteristics, type of treatment and treatment responses of 117 CL patients. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this study, 117 Syrian CL patients, who applied to the outpatient clinic were presented. R Re es su ul lt ts s: : Sixty two of the patients were female (53%) and 55 (% 47) were male. The mean age of the patients was 16±1,4. Fifty two point one percent of the patients had one, 38.5% had two or three and 9.4% had more than three lesions. The mean duration of the lesions was 7 months, while the average duration of residence time in Turkey was 6 months. Ninety six point six percent of the lesions had a diameter less than 5 cm and the rest had larger lesions. Most of the lesions were localized on the face (43.1%) and extremities (42.8%). The majority of the lesions on the face were at the cheeks (53.8%), one of them was on the eyelid, 2 on the lip, 4 on the ear and 9 on the nose. The patients were treated with intralesional antimony compounds or cryotherapy. Lesions of the patients, who were treated with the antimony compounds recovered faster and with superior cosmetic results. C Co on nc cl lu us si io on n: : Intralesional antimone therapy is an effective and cosmetically successful treatment option without any significant side effects for CL. K Ke ey yw wo or rd ds s: : Leishmaniasis, cutaneous; cryotherapy; injections, intralesional Ö ÖZ ZE ET T A Am ma aç ç: : Kutanöz layşmanyazis (KL), deride nodülo-ülseratif lezyonlarla seyreden bir hastalıktır. Hastalık, Türkiye'nin bazı bölgeleri ile Suriye'de endemiktir. Bu çalışmanın amacı; kliniğimize başvuran 117 kutanöz layşmanyazis tanılı hastanın demografik ve klinik özelliklerinin, bu hastalara uygulanan tedavi seçeneklerinin ve tedaviye olan yanıtlarının değerlendirilmesidir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmada, dermatoloji polikliniğine başvuran 117 Suriye'li kutanöz layşmanyazis tanılı hasta değerlendirilmiştir. B Bu ul lg gu ul la ar r: : Çalışmaya dahil edilen hastaların 62'si kadın (%53), 55'i (%47) erkekti. Hastaların yaş ortalaması 16±1,4 yıl idi. Yüzde 52,1 hastanın tek, %38,5'inin 2 veya 3, %9,4'ünün ise üçten fazla lezyonu vardı. Lezyonların klinik olarak var olma süresi ortalama 7 ay iken, hastaların Türkiye'de ikamet etme sürelerinin ortalama...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cutaneous Leishmaniasis: Evaluation of 117 Syrian Immigrants

Karaosmanoğlu¹,

Şahin²,

Vahaboğlu³

et al. 2019

Turkiye Klinikleri J Med Sci

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“…It is required to use advanced diagnostic methods such as histopathological examination, culture and molecular methods to analyze skin lesion biopsies, when the parasite cannot be detected in the smear. The low number of parasites in the histopathological examination, particularly in chronic cases, may increase the margin of error ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

The Investigation of the Association of Cutaneous Leishmaniasis in Biopsy Specimens of the Patients with Granulomatous Disease and Skin Cancer Using the Molecular Method

Çulha

Doğramacı

Hakverdı

et al. 2020

IJPA

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Background: Clinically, cutaneous leishmaniasis (CL) can be confused with granulomatous diseases and skin cancers, and it may lead to erroneous diagnosis and treatment. Diagnosis based and histopathology can have some difficulties due to low number of parasites, especially in chronic CL cases. We aimed to emphasize the necessity of considering CL in the differential diagnosis for cases of granulomatous diseases and basal cell carcinoma, particularly in areas where CL is endemic. Methods: One hundred and seven paraffin-embedded tissue biopsy specimens were selected from the archive, as of 2002, of Pathology Department, School of Medicine, University of Hatay Mustafa Kemal in Hatay, Turkey. After DNA isolation, performed with the samples were used for PCR analysis with specific 13A, 13B primers targeting kinetoplastid DNA (kDNA) found in all Leishmania species. Another PCR was performed with LITSR and L5.8S primers targeting ITS-1 internal-transcribed-spacer-1 (ITS-1) region to subtype positive samples. Then these samples were further analyzed for subtyping with PCR-RFLP using HaeIII enzyme (BsuRI). Results: Ten out of 107 tissue specimens were positive via kDNA-PCR. Lupus vulgaris, sarcoidosis, skin lymphoma and Leishmania cutis appeared in 9 out of 10 positive specimens. One of the cases presented with a mass on the cheek and was pre-diagnosed with hemangioma, but leishmaniasis did not appear. All of 10 specimens were diagnosed as granulomatous dermatitis. Two out of 10 samples, found positive with kDNA-PCR, were analyzed with ITS-1-PCR and identified as L. infantum/donovani after RFLP. Conclusion: Molecular methods should be utilized in the differential diagnosis of CL to eliminate false diagnoses of granulomatous diseases and skin cancers.

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“…Kutanöz leishmaniasis (KL) deride uzun süren nodülo-ülseratif lezyonlarla seyredip atrofik skatrisle iyileşen bir deri hastalığı tablosudur. Hastalığın klinik ve epidemiyolojik özellikleri parazitler, konak ve çevreyi içeren çok sayıda faktörün rol oynamasına bağlı olarak değişmektedir (1)(2)(3). KL tanısı; mikroskobik inceleme, kültür ortamında izolasyon, genomda bulunan spesifik dizilerin moleküler yöntemlerle incelenmesi yöntemleri ile veya hasta serumunda antikorların arandığı serolojik testlerle yapılabilmektedir.…”

Section: Introductionunclassified

The Diagnostic Value of Lesional Skin Smears Performed by Experienced Specialist in Cutaneous Leishmaniasis and Routine Microbiology Laboratory

An¹,

Harman²,

Çavuş³

et al. 2019

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Leishmaniasis, 98 ülkede 12 milyon insanı etkileyen vektör kaynaklı yaygın bir enfeksiyondur. Tanıda en sık kullanılan yöntem leishmania yaymaların mikroskobik incelemesidir. Bu yöntemin tanısal değeri değerlendiricinin deneyimine göre değişkenlik gösterir. Bu çalışmada kutanöz leishmaniasis tanısında lezyonal yaymaların değerlendirilmesinde deneyimin ne kadar önemli olduğunun saptanması amaçlandı. Yöntemler: Bu çalışmaya 2016 yılının Ocak ve Aralık ayları arasında Dicle Üniversitesi Tıp Fakültesi Hastanesi Deri ve Zührevi Hastalıklar Polikliniği'ne başvuran ve deri leishmaniasisi kuşkusu uyandıran lezyonlara sahip hastalar alındı. Bu hastaların tümünden hem rutin mikrobiyoloji laboratuvarında hem de kutanöz leishmaniasisin klinik ve tanısında deneyimli uzman tarafından olmak üzere ayrı yaymalar yapıldı ve birbirlerinden bağımsız olarak değerlendirildi. Bulgular: Çalışmaya alınan 98 olgunun 70'inde kutanöz leishmaniasis tanısı laboratuvar değerlendirmeleri ile doğrulandı. Kutanöz leishmaniasisin klinik ve tanısında deneyimli uzman tarafından yapılan yaymaların pozitifliği (%95,7) rutin mikrobiyoloji laboratuvarı tarafından yapılan yaymaların pozitifliğinden (%42,9) yüksekti (p<0,001). Sonuç: Çalışmamızdaki veriler gösterdi ki kutanöz leishmaniasis tanısı için yaymalar kutanöz leishmaniasisin klinik ve tanısında deneyimli uzmanlar tarafından yapılmalı ve değerlendirilmelidir.

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Clinical practice guidelines for the diagnosis and treatment of cutaneous leishmaniasis in Turkey

Cited by 48 publications

References 43 publications

Cutaneous Leishmaniasis: Evaluation of 117 Syrian Immigrants

Cutaneous Leishmaniasis: Evaluation of 117 Syrian Immigrants

The Investigation of the Association of Cutaneous Leishmaniasis in Biopsy Specimens of the Patients with Granulomatous Disease and Skin Cancer Using the Molecular Method

The Diagnostic Value of Lesional Skin Smears Performed by Experienced Specialist in Cutaneous Leishmaniasis and Routine Microbiology Laboratory

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