Clinical practice recommendations for infectious disease management of diabetic foot infection (DFI) – 2023 SPILF

Bonnet, E.; Maulin, L.; Senneville, E.; Castan, B.; Fourcade, C.; Loubet, P.; Poitrenaud, D.; Schuldiner, S.; Sotto, A.; Lavigne, J.P.; Lesprit, P.

doi:10.1016/j.idnow.2023.104832

Cited by 3 publications

(1 citation statement)

References 169 publications

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“…Treatment of DFI requires a multidisciplinary approach and tailoring of antibiotic therapies to the causative pathogen to improve efficacy and reduce antimicrobial resistance [ 10 ]. Methicillin-susceptible Staphylococcus aureus (MSSA) and other Gram-positive cocci are predominant in DFIs without deep tissue involvement or systemic signs (mild infections) [ 10 , 11 ]. Therefore, DFI guidelines recommend oral amoxicillin-clavulanic acid as the first choice for empirical treatment of mild infections in patients with no history of MRSA infection or colonization and without recent hospitalization [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring therapeutic options for mild diabetic-related foot infections: a comparative in vitro study of cefditoren versus amoxicillin/clavulanic acid

Alou,

Gómez-Rubio,

Giménez Mestre

et al. 2024

Rev Esp Quimioter

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Skin and soft tissue infections (SSTIs), and particularly diabetic-related foot infections (DFI), present diagnostic and therapeutic complexities, often leading to severe complications. This study aims to evaluate the in vitro efficacy of cefditoren and amoxicillin/clavulanic acid against typical DFI pathogens. Clinical samples from 40 patients with mild SSTIs were analyzed, revealing a predominance of Staphylococcus spp. and Streptococcus spp. species. Cefditoren exhibited activity against 90% of isolates, with superior potency over amoxicillin/clavulanic acid. These findings underscore the utility of cefditoren in empirical treatment of DFI, although a larger sample size would be desirable for further validation.

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Section: Introductionmentioning

confidence: 99%

Exploring therapeutic options for mild diabetic-related foot infections: a comparative in vitro study of cefditoren versus amoxicillin/clavulanic acid

Alou,

Gómez-Rubio,

Giménez Mestre

et al. 2024

Rev Esp Quimioter

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Microbiologic and Histopathologic Features of Pedal Osteomyelitis

Madrid-Morales,

Maier,

Boda

et al. 2024

Open Forum Infectious Diseases

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Determining the Best Noninvasive Test for Peripheral Arterial Disease Diagnosis to Predict Diabetic Foot Ulcer Healing in Patients Following Endovascular Revascularization

Álvaro-Afonso,

García-Álvarez,

García-Morales

et al. 2024

Healthcare

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Background/Objectives: To analyze the best noninvasive tests prognosis marker in patients with diabetic foot ulcer (DFU) who underwent endovascular revascularization based on clinical outcomes, such as healing rate, time to heal, and free amputation survival after at least a six-month follow-up. Methods: A multicentric prospective observational study was performed with 28 participants with ischemic or neuroischemic DFU who came to the participant centers and underwent endovascular revascularization between January 2022 and March 2023. Toe systolic pressure (TP), ankle systolic pressure (AP), the ankle brachial pressure index (ABPI), the toe brachial pressure index (TBPI), transcutaneous pressure of oxygen (TcPO2), and skin perfusion pressure (SPP) were evaluated using PeriFlux 6000 System, Perimed, Sweden, before (Visit 0) and four weeks after revascularization (Visit 1). The primary clinical outcome was an evaluation of the clinical evolution of noninvasive tests comparing Visit 0 and Visit 1, estimating the sensitivity for predicting wound healing of noninvasive tests at six months following initial recruitment. Results: After six months, 71.43% (n = 20) of DFU healed, four patients (14.3%) received major amputations, and one (3.5%) died. The two tests that best predicted wound healing after revascularization according to the ROC curve were TcPO2 and TP with sensitivities of 0.89 and 0.70 for the cut-off points of 24 mmHg and 46 mmHg, respectively. Conclusions: TcPO2 and TP were the two tests that best predicted wound healing in patients who underwent endovascular revascularization. Clinicians should consider the importance of the evaluation of microcirculation in the healing prognosis of patients with diabetic foot ulcers.

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Clinical practice recommendations for infectious disease management of diabetic foot infection (DFI) – 2023 SPILF

Cited by 3 publications

References 169 publications

Exploring therapeutic options for mild diabetic-related foot infections: a comparative in vitro study of cefditoren versus amoxicillin/clavulanic acid

Exploring therapeutic options for mild diabetic-related foot infections: a comparative in vitro study of cefditoren versus amoxicillin/clavulanic acid

Microbiologic and Histopathologic Features of Pedal Osteomyelitis

Determining the Best Noninvasive Test for Peripheral Arterial Disease Diagnosis to Predict Diabetic Foot Ulcer Healing in Patients Following Endovascular Revascularization

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