Clinical predictors for analgesic response to radiotherapy in patients with painful bone metastases

Habberstad, Ragnhild; Frøseth, Trude Camilla Salvesen; Aass, Nina; Bjerkeset, Ellen; Абрамова, Т. Я.; Garcia-Alonso, Elena; Caputo, Mariangela; Rossi, Romina; Boland, Jason W; Brunelli, Cinzia; Lund, J-Å.; Kaasa, Stein; Klepstad, Pål

doi:10.1093/annonc/mdz261.003

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Second, given the low level of CP intensity at baseline, participants may have had difficulty perceiving changes after each intervention. These latter findings are supported by previous work showing more moderate to severe pain at baseline predicts more significant responses to analgesic interventions [ 35 , 36 ].…”

Section: Discussionsupporting

confidence: 86%

Feasibility and acceptability of virtual reality for cancer pain in people receiving palliative care: a randomised cross-over study

Austin

Siddall

Lovell

2022

Support Care Cancer

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Context Pain management in palliative care remains inadequate; the development of innovative therapeutic options is needed. Objectives To determine the feasibility and preliminary effectiveness for larger randomised controlled trials of 3D head-mounted (HMD) virtual reality (VR) for managing cancer pain (CP) in adults. Methods Thirteen people receiving palliative care participated in a single-session randomised cross-over trial, after which they completed a qualitative semi-structured interview. We also compared the effects of 3D HMD VR and 2D screen applications on CP intensity and levels of perceived presence. Feasibility was assessed with recruitment, completion rates and time required to recruit target sample. Results Although recruitment was slow, completion rate was high (93%). Participants reported that the intervention was acceptable and caused few side effects. Although participants reported significantly reduced CP intensity after 3D HMD VR (1.9 ± 1.8, P = .003) and 2D screen applications (1.5 ± 1.6, P = .007), no significant differences were found between interventions (−.38 ± 1.2, 95% CI: −1.1–.29, P = .23). Participants reported significantly higher levels of presence with the 3D HMD VR compared to 2D screen (60.7 ± SD 12.4 versus 34.3 ± SD 17.1, mean 95% CI: 16.4–40.7, P = .001). Increased presence was associated with significantly lower pain intensity (mean 95% CI: −.04–−0.01, P = 0.02). Conclusions Our preliminary findings support growing evidence that both 3D and 2D virtual applications provide pain relief for people receiving palliative care. Given the relative lack of cybersickness and increasing access to portable VR, we suggest that larger clinical studies are warranted.

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Section: Discussionsupporting

confidence: 86%

Feasibility and acceptability of virtual reality for cancer pain in people receiving palliative care: a randomised cross-over study

Austin

Siddall

Lovell

2022

Support Care Cancer

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Nutrition impact symptom monitoring and weight loss outcomes: a longitudinal radiotherapy study

Urrizola,

Dajani,

Aass

et al. 2024

BMJ Support Palliat Care

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ObjectivesNutrition impact symptoms (NIS) are associated with weight loss (WL), and decreased energy intake in cross-sectional studies. We aimed to ascertain associations between changes in NIS burden, energy intake and WL over time in patients with advanced cancer.MethodsAdult patients from an observational radiotherapy study for painful bone metastases self-reported NIS and WL using the Patient-Generated Subjective Global Assessment tool (PG-SGA) at baseline and week eight (W8). NIS burden, the sum of NIS per patient, categorised as 0, 1–2 and ≥3 with changes defined as 2-point differences from baseline to W8 were used. Energy intake was assessed by 24-hour recall interviews.Results111 patients (72.1%) were analysed and grouped by NIS burden; 0 NIS (44.1%), 1–2 NIS (30.6%) and ≥3 NIS (25.2%). Patients with NIS burden of ≥3 reported higher baseline WL compared with those with 1–2 or 0 NIS (46.4% vs 18.2% vs 10.2%, respectively, p=0.002). At W8, 21 patients (19%) reported improved NIS burden, accompanied by a lower proportion of severe (≥5%) new-onset WL (19% vs 42.1%) and higher energy intake (median 29.6 vs 21.2 kcal/kg) than those with worsened NIS burden (17.1%).ConclusionsNIS management may improve energy intake and prevent WL, emphasising the importance of systematic follow-up and interventions.ClinicalTrials.gov registrationNCT02107664

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Clinical predictors for analgesic response to radiotherapy in patients with painful bone metastases

Cited by 2 publications

References 9 publications

Feasibility and acceptability of virtual reality for cancer pain in people receiving palliative care: a randomised cross-over study

Feasibility and acceptability of virtual reality for cancer pain in people receiving palliative care: a randomised cross-over study

Nutrition impact symptom monitoring and weight loss outcomes: a longitudinal radiotherapy study

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