Clinical Predictors of Referral for and Yield of Genetic Testing in Peripartum Cardiomyopathy

Reza, Nosheen; Packard, Elizabeth A; Goli, Rahul R.; Chowns, Jessica L.; Owens, Anjali Tiku; Arany, Zoltàn; Lewey, Jennifer

doi:10.1016/j.jchf.2023.03.012

Cited by 3 publications

(1 citation statement)

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“…The IPAC (Investigations of Pregnancy Associated Cardiomyopathy) study followed 100 women in North America with PPCM for 1 year after delivery and found that LVEF < 30% was associated with lower rates of myocardial recovery and an increased risk of adverse events [ 9 ]. Severe left ventricular (LV) systolic dysfunction at PPCM presentation has also been shown to be associated with the presence of a genetic variant causal for dilated cardiomyopathy (DCM) [ 10 ]. Additional predictors of worse outcome include LV dilation (LV end diastolic diameter > 6 cm), LV thrombus, right ventricular systolic dysfunction, obesity, and African ancestry [ 8 ].…”

Section: Heart Failure In Pregnancymentioning

confidence: 99%

Contemporary Management of Cardiomyopathy and Heart Failure in Pregnancy

Afari,

Sheehan,

Reza

2024

Cardiol Ther

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Cardiovascular disease is the primary cause of pregnancy-related mortality and morbidity in the United States, and maternal mortality has increased over the last decade. Pregnancy and the postpartum period are associated with significant vascular, metabolic, and physiologic adaptations that can unmask new heart failure or exacerbate heart failure symptoms in women with known underlying cardiomyopathy. There are unique management considerations for heart failure in women throughout pregnancy, and it is imperative that clinicians caring for pregnant women understand these important principles. Early involvement of multidisciplinary cardio-obstetrics teams is key to optimizing maternal and fetal outcomes. In this review, we discuss the unique challenges and opportunities in the diagnosis of heart failure in pregnancy, management principles along the continuum of pregnancy, and the safety of heart failure therapies during and after pregnancy.

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Section: Heart Failure In Pregnancymentioning

confidence: 99%