Clinical predictors of response to clozapine in Tunisian patients with treatment resistant schizophrenia

Aissa, A.; Jouini, R.; Ouali, Uta; Zgueb, Yosra; Nacef, F.; Hechmi, Z. El

doi:10.1016/j.comppsych.2021.152280

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Also, they only focused on rst-episode patients and the long-term effect of antipsychotic treatment is still unknown. Thus, it is important to validate structural covariance networks in chronic patients with schizophrenia because a certain number of patients respond to antipsychotics during the phase of rst episode psychosis but become treatment-resistant in the long term [46,47]. Wannan et al reported that structural covariance networks did not differ between the TRS and HC groups, while they did not include patients with non-TRS [20,23].…”

Section: Discussionmentioning

confidence: 99%

Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia

Tsugawa,

Honda,

Noda

et al. 2023

Schizophrenia Bulletin

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Background and Hypothesis Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia. Study Design We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network-based statistics were used to examine the difference in structural covariance networks among the 3 groups. Moreover, the relationship between altered individual differentiated structural covariance and clinico-demographics was also explored. Study Results Patients with non-TRS exhibited greater structural covariance compared with HC, mainly in the fronto-temporal and fronto-occipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group. Conclusions These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease.

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Section: Discussionmentioning

confidence: 99%

Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia

Tsugawa,

Honda,

Noda

et al. 2023

Schizophrenia Bulletin

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Association Between Clozapine Plasma Concentrations and Treatment Response: A Systematic Review, Meta-analysis and Individual Participant Data Meta-analysis

et al. 2023

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Associations between structural covariance network and antipsychotic treatment response in schizophrenia

Nakajima,

Tsugawa,

Honda

et al. 2023

Preprint

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Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia. We therefore organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network based statistics were used to examine the difference in structural covariance networks among the three groups. Moreover, the relationship between altered individual differentiated structural covariance and clinico-demographics was also explored. Patients with non-TRS exhibited greater structural covariance compared to HC, mainly in the fronto-temporal and fronto-occipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group. These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease.

show abstract

Clinical predictors of response to clozapine in Tunisian patients with treatment resistant schizophrenia

Cited by 3 publications

References 26 publications

Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia

Associations Between Structural Covariance Network and Antipsychotic Treatment Response in Schizophrenia

Association Between Clozapine Plasma Concentrations and Treatment Response: A Systematic Review, Meta-analysis and Individual Participant Data Meta-analysis

Associations between structural covariance network and antipsychotic treatment response in schizophrenia

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