Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture

Choung, Rok Seon; Ruff, Kevin C.; Malhotra, Ananya; Herrick, Linda M.; Locke, G. Richard; Harmsen, William S.; Zinsmeister, Alan R.; Talley, Nicholas J.; Saito, Yuri

doi:10.1111/j.1365-2036.2011.04625.x

Cited by 122 publications

(109 citation statements)

References 35 publications

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“…In one published study there was a correlation between orocecal transit by scintigraphy and lactulose hydrogen breath test suggesting that gut motility changes, not SIBO, explained the positive breath tests in IBS [23]. Two additional studies looking at duodenal aspirate cultures in patients found conflicting results, with one providing evidence that SIBO was unusual in IBS [24] and the other suggesting that SIBO was more common in patients with diarrhea-predominant IBS (37.5%) compared with controls without diarrhea (27.3%) [25]. …”

Section: Discussionmentioning

confidence: 99%

Motility Abnormalities in Irritable Bowel Syndrome

et al. 2014

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Background/Aims: The intestinal pathophysiology in irritable bowel syndrome (IBS) is largely unknown. The lactulose breath test has been used to identify small bowel bacterial overgrowth in these patients. Methods: We studied intestinal transit in patients with IBS using of the SmartPill® (SP) wireless pH/pressure recording capsule and performed lactulose breath tests to look for physiologic abnormalities. Results: A total of 35/46 (76%) of the IBS patients had prolonged gastric emptying times. Constipation-predominant disease was associated with prolonged gut transit times. The mean hours ± SD for colonic transit time in the constipation group was 71.7 ± 61.1 (n = 13) compared with 22.5 ± 14.9 (n = 14) for diarrhea-predominant and 26.4 ± 21.5 (n = 20) for mixed clinical subtype (p = 0.0010). No correlation between small bowel transit time and abnormal breath hydrogen or methane excretion in the 46 combined patients with IBS was seen. Conclusions: Delayed gastric emptying was identified in IBS and in some patients may contribute to at least a component of their symptoms. Constipation-predominant IBS is associated with prolonged gut transit times. Otherwise, transit abnormalities do not appear to be important in IBS. Intestinal transit did not correlate with breath test results.

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Section: Discussionmentioning

confidence: 99%

Motility Abnormalities in Irritable Bowel Syndrome

et al. 2014

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“…In another study, duodenal fluids were endoscopically collected from 148 IBS patients. Bacterial volume of ≥10 5 cfu/mL was detected in only 2% of IBS patients, whereas in the control group (n=542), over 10% of people had SIBO 10. Tests that measure actual bacterial volume do not help demonstrate the relationship between IBS and SIBO.…”

Section: Introductionmentioning

confidence: 93%

The significance of infectious disease and microbiota in functional gastrointestinal disorders

Tsuchiya

2017

J of Gen and Family Med

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The definition of functional gastrointestinal disorders (FGID) used to be disorders that do not manifest into organic abnormalities. However, it was pointed out that chronic GI dysfunctions can develop following bacterial infections such as acute gastroenteritis and viral infections, and some organic changes in the epithelial cell structure, immunocompetent cells, and inflammatory cytokines were revealed. Recent advancements in analytical methods helped discover changes in the intestinal microbiota of patients with FGID. Correlations between the effects on the enteric environment and clinical conditions and symptoms of FGID are drawing increasing attention.

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“…The factors can be divided into anatomical (stenoses -strictures, blind loop, diverticulum, duplication), associated with disturbances to the function (diabetic autonomic neuropathy, intestinal pseudo-obstruction syndrome, systemic scleroderma, achlorhydria, slow gastrointestinal motility), and conditions predisposing to the development of bacteria (primary and secondary immunodeficiency, intestinal fistulas, achlorhydria, removal of the ileocecal valve) [22]. It is said that advanced age, use of narcotics, IBD, steatorrhea, intestinal diverticula and pancreatitis are more frequent in the group of patients with SIBO, which can be established through microbiological analysis -cultures of duodenal aspirates [23].…”

Section: Pathogenesismentioning

confidence: 99%

Current views on the etiopathogenesis, clinical manifestation, diagnostics, treatment and correlation with other nosological entities of SIBO

Miazga

Osiński

Cichy

et al. 2015

Advances in Medical Sciences

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Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture

Abstract: SUMMARY BackgroundThere has been increasing interest in small intestinal bacterial overgrowth (SIBO) after reports of a link with irritable bowel syndrome (IBS), yet our understanding of this entity is limited.

Cited by 122 publications

References 35 publications

Motility Abnormalities in Irritable Bowel Syndrome

Motility Abnormalities in Irritable Bowel Syndrome

The significance of infectious disease and microbiota in functional gastrointestinal disorders

Current views on the etiopathogenesis, clinical manifestation, diagnostics, treatment and correlation with other nosological entities of SIBO

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