Clinical predictors of the efficacy of a pulmonary rehabilitation programme in patients with COPD

Vagaggini, Barbara; Costa, Francesco; Antonelli, Sandra; Simone, Claudia De; Cusatis, Gianna De; Martino, Federica; Santerini, Sabrina; Paggiaro, Pierluigi

doi:10.1016/j.rmed.2009.01.023

Cited by 71 publications

(85 citation statements)

References 29 publications

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“…Similar results have been already demonstrated in a smaller group of patients taken from a real-life setting and submitted for outpatient rehabilitation [38]. Thus, these patients should not be definitively excluded from standard PR in the usual clinical setting.…”

Section: Discussionsupporting

confidence: 84%

Efficacy of standard rehabilitation in COPD outpatients with comorbidities

Crisafulli

Gorgone²,

Vagaggini³

et al. 2010

Eur Respir J

110

103

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A prospective study was performed to confirm the prevalence pattern of the most frequent co-morbidities and to evaluate whether characteristics of patients, specific comorbidities and increasing number of comorbidities are independently associated with poorer outcomes in a population with complex chronic obstructive pulmonary disease (COPD) submitted for pulmonary rehabilitation (PR).316 outpatients (mean¡SD age 68¡7 yrs) were studied. The outcomes recorded were comorbidities and proportion of patients with a pre-defined minimally significant change in exercise tolerance (6-min walk distance (6MWD) +54 m), breathlessness (Medical Research Council (MRC) score -1 point) and quality of life (St George's Respiratory Questionnaire -4 points).62% of patients reported comorbidities; systemic hypertension (35%), dyslipidaemia (13%), diabetes (12%) and coronary disease (11%) were the most frequent. Of these patients, .45% improved over the minimum clinically important difference in all the outcomes. In a logistic regression model, baseline 6MWD (OR 0.99, 95% CI 0.98-0.99; p50.001), MRC score (OR 12.88, 95% CI 6.89-24.00; p50.001) and arterial carbon dioxide tension (OR 1.08, 95% CI 1.00-1.15; p50.034) correlated with the proportion of patients who improved 6MWD and MRC, respectively. Presence of osteoporosis reduced the success rate in 6MWD (OR 0.28, 95% CI 0.11-0.70; p50.006).A substantial prevalence of comorbidities in COPD outpatients referred for PR was confirmed. Only the individual's disability and the presence of osteoporosis were independently associated with poorer rehabilitation outcomes.

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Section: Discussionsupporting

confidence: 84%

Efficacy of standard rehabilitation in COPD outpatients with comorbidities

Crisafulli

Gorgone²,

Vagaggini³

et al. 2010

Eur Respir J

110

103

View full text Add to dashboard Cite

show abstract

“…Our finding that there were no significant changes between groups implies that PR yields clinical benefits for all groups. Some studies have suggested that patients with less severe obstruction have greater improvements in exercise tolerance [15], but this was not the case in our study.…”

Section: Discussioncontrasting

confidence: 88%

Pulmonary Rehabilitation: A Retrospective Study in Eastern North Carolina

Chalise

Shaheen

Rizwan

et al. 2016

North Carolina Medical Journal

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“…Regardless of the COPD-systemic inflammatory related nature of comorbidities, an intriguing issue is whether comorbidities may be related to the response to rehabilitation [7,25]. Recently, a retrospective cohort study examined this question.…”

mentioning

confidence: 99%