Clinical predictors to cognitive impairment in multiple sclerosis patients

Elshebawy, Haidy; Fahmy, Ebtesam Mohamed; Elfayoumy, Nervana Mohamed; Abdelalim, Ahmed; Ismail, Rania Shehata

doi:10.1186/s41983-021-00292-6

Cited by 20 publications

(8 citation statements)

References 22 publications

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“…Considering presence of higher education, it was stated to have favorable effect on MS patients’ cognitive functions [ 24 ]; therefore, our study revealed higher prevalence of cases with intact cognition and substantially lower number of severe cognitive impairment in participants with higher education.…”

Section: Discussionmentioning

confidence: 55%

Cognitive impairment and depression in patients with relapsing–remitting multiple sclerosis depending on age and neuroimaging findings

Kopchak

Odintsova

2021

Egypt J Neurol Psychiatry Neurosurg

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Background Multiple sclerosis is an insidious, disabling, both physically and mentally, demyelinating disease of the central nervous system. This work aims to evaluate relationships between cognitive impairment in separate domains, depression and their correspondence with MRI-findings, as well as the influence on each other’s manifestations, in patients with relapsing–remitting multiple sclerosis. Results Visual–spatial/executive functions and memory domains suffered more frequently than others in the study subjects under 40 years; in patients over 40 years old memory, visual–spatial/executive functions and abstract thinking impairment prevailed the most. Such cognitive domains as memory, language, abstract thinking, visual–spatial and executive functions were impacted in both groups of patients even without the apparent cognitive decline according to MoCA scale. Presence of depression impacted language and attention more prominently than the rest of the domains only in participants younger 40 years. According to the MRI, frontal lobe, corpus callosum and periventricular area were affected more often compared to other brain regions in case of cognitive impairment; meanwhile, combined lesions of frontal lobe and corpus callosum, fronto-temporal region were associated with depression. Conclusion Cognitive impairment and depression are one of the common, yet disabling and socially disrupting manifestations of MS. Quite frequently such complaints are neglected or considered as parts of comorbidities. At the same time cognitive impairment can be amplified by depression, especially in patients under 40 years.

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Section: Discussionmentioning

confidence: 55%

Cognitive impairment and depression in patients with relapsing–remitting multiple sclerosis depending on age and neuroimaging findings

Kopchak

Odintsova

2021

Egypt J Neurol Psychiatry Neurosurg

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“…A growing body of evidence shows cognitive dysfunction in people with MS, possibly due to white and gray matter lesions 26–30 . Although cognitive dysfunction is common in patients with RRMS, cognitive performance is not routinely screened in clinical practice 31 .…”

Section: Discussionmentioning

confidence: 99%

“…A growing body of evidence shows cognitive dysfunction in people with MS, possibly due to white and gray matter lesions. [26][27][28][29][30] Although cognitive dysfunction is common in patients with RRMS, cognitive performance is not routinely screened in clinical practice. 31 MACFIMS questionnaire is a valid approach for the assessment of neuropsychological outcomes in MS patients.…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance is associated with cognitive dysfunction in multiple sclerosis patients: A cross‐sectional study

Ayromlou,

Hosseini,

Khalili

et al. 2023

J Neuroendocrinology

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Multiple sclerosis (MS) is a progressive inflammatory neurodegenerative disease of the nervous system accompanied by demyelination. MS‐associated cognitive impairments mainly involve recent memory, information processing speed, stable memory, and executive function. Moreover, MS is associated with impaired glucose and insulin metabolism, which can exacerbate cognitive decline. The present study aimed to compare the cognitive status of MS patients with and without insulin resistance. In this cross‐sectional study, 74 relapsing–remitting multiple sclerosis diagnosed patients were enrolled. Indicators of insulin resistance, including fasting blood glucose, insulin level, and homeostatic model assessment of insulin resistance (HOMA‐IR) index, were measured. They were then divided into two groups based on the results of the HOMA‐IR index. Cognition status was evaluated by the minimal assessment of cognitive function in multiple sclerosis battery. The prevalence of insulin resistance was 37.8%, and the prevalence of cognitive decline was estimated to be 67.56%. Mean scores of the California verbal learning test (CVLT), CVLT delayed free recall, controlled oral word association test, and judgment of line orientation tests were significantly lower in MS patients with insulin resistance than without. In addition, a negative correlation was demonstrated between the results of the CVLT, CVLT delayed free recall, controlled oral word association test, judgment of line orientation tests, brief visuospatial memory test, and Delis‐Kaplan executive function system sorting tests and fasting insulin levels. Greater verbal memory and spatial comprehension impairments were observed in MS patients with insulin resistance.

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“…Cognitive dysfunction significantly reduces the quality of life of patients, causes unemployment in people of working age, affects social participation, leads to deficits in the implementation of daily activities, affects the survival of personal relationships, and adherence to treatment (Amato et al, 2006;Elshebawy et al, 2021). Klímová (2020) points out the essential importance of immunomodulatory therapy for patients with MS, where cognitive deficits cannot be effectively influenced.…”

Section: Discussionmentioning

confidence: 99%

Quality of life in patients with multiple sclerosis

Hudáková,

Majerníková,

Obročníková

2023

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Objective: Multiple sclerosis is characterized by a diverse clinical course and high disability of the disease. The aim of the study was to identify and analyse the quality of life of patients with multiple sclerosis. Methods: The authors collected data using WHOQOL-BREF tool. The research sample consisted of 81.40% women and 18.60% men. In terms of age, the largest representation was recorded in persons aged 31-50 (56.98%). The research sample was divided into two groups: persons with a disease duration of up to 11 years (60.47%), and persons with a disease duration over 11 years (39.53%). Results: We compared the research findings in each domain with the standard population Statistical significance was confirmed in the physical domain in the area of mobility (p = 0.002**). Pain and discomfort were perceived more positively in both groups (M = 2.54 and M = 2.93) than in the population standard (PN = 4.03). We confirmed the statistical significance of survival in the area of concentration (p = 0.045*). The availability of health services proved to be important (p = 0.027**) in the environmental field. When comparing both groups in terms of disease duration, statistical significance was confirmed in the health satisfaction domain (p = 0.049*). Conclusion: Decreased ability to move independently represents the greatest correlation with decreased quality of life. For patients with multiple sclerosis, it is advisable to create checklists and rehabilitation programs to improve their quality of life.

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Clinical predictors to cognitive impairment in multiple sclerosis patients

Cited by 20 publications

References 22 publications

Cognitive impairment and depression in patients with relapsing–remitting multiple sclerosis depending on age and neuroimaging findings

Cognitive impairment and depression in patients with relapsing–remitting multiple sclerosis depending on age and neuroimaging findings

Insulin resistance is associated with cognitive dysfunction in multiple sclerosis patients: A cross‐sectional study

Quality of life in patients with multiple sclerosis

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