Clinical Presentation and Causes of Recurrent Corneal Erosion Syndrome

Díez-Feijóo, Elio; Grau, Arturo; Abusleme, Eugenia I.

doi:10.1097/ico.0000000000000111

Cited by 45 publications

(34 citation statements)

References 13 publications

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“…The average duration of the ulcer before use of xCMHA-S was 25.5 6 8.3 days while the mean time to ulcer healing when treated with xCMHA-S was 13.4 6 4.2 days, these times being significantly different (P ¼ 0.00005). Dogs with recurrent epithelial erosion associated with defective basal epithelial cell adhesion to the underlying basement membrane (termed spontaneous chronic corneal epithelial defects [SCCEDs]) 17,18 and analogous to recurrent epithelial erosions in humans 19,20 ) did not heal with xCMHA-S and required epithelial debridement before healing occurred. These ulcers are readily diagnosed as they have a clearly defined devitalized epithelial margin 17,18 and are denoted in Table 3 as those with superficial erosions.…”

Section: Treatment Of Chronic Nonhealing Ulcers In Dogsmentioning

confidence: 99%

Topical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals

Williams

Wirostko²,

Gum

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Section: Treatment Of Chronic Nonhealing Ulcers In Dogsmentioning

confidence: 99%

Topical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals

Williams

Wirostko²,

Gum

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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“…T2DM affects the morphological, physiological, metabolic and clinical state of the cornea, and microstructural changes can still exist even with a normal slit lamp examination and can predispose patients to disease [ 2 ]. The prevalence of corneal abnormalities such as punctate keratitis, recurrent corneal erosion syndrome, persistent epithelial defects, reduced corneal sensitivity and endothelial damage is increased in diabetics [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Epithelial changes with corneal punctate epitheliopathy in type 2 diabetes mellitus and their correlation with time to healing

Tian

et al. 2018

BMC Ophthalmol

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BackgroundTo study basal epithelial cell (BEC), sub-basal nerve plexus (SBN) and Langerhans cell (LC) density in patients with type 2 diabetes mellitus (T2DM) with corneal punctate epitheliopathy (CPE) and to assess their association with time to healing of CPE.MethodsRetrospective study of in vivo confocal microscopy (IVCM) in 160 eyes from 160 patients with T2DM diagnosed with CPE due to a single cause. Key exclusion criteria included multiple-causes for CPE or treatment with autologous serum. A total of 149 eyes from 149 gender- age- and aetiolgy-matched patients with CPE without T2DM comprised the control group. Electronic records were reviewed for demographic features, history of T2DM and aetiology of CPE. Density of BEC, SBN and LC were compared between the two groups.ResultsThe healing time in days for CPE with different aetiologies in the T2DM and control groups were as follows: dry eye (21.56 ± 2.41; 7.00 ± 2.19; P = 0.001); meibomian gland dysfunction (26.42 ± 6.04; 9.21 ± 2.55; P = 0.001); cataract extraction (38.00 ± 19.62; 25.83 ± 11.49; P = 0.043); drug induced (53.19 ± 18.83; 41.86 ± 23.87; P = 0.018) and exposure (38.25 ± 14.13; 29.00 ± 13.67; P = 0.026). LC density was 38.70 ± 9.65 cells/mm2 in the T2DM group comparedwith 25.53 ± 3.54 cells/mm2 in the controls (P = 0.001). SBN density was 11.76 ± 1.69 mm/mm2 in the T2DM group compared with 20.92 ± 1.43 mm/mm2 in the controls (P = 0.001). BEC density in the T2DM group was 4982 ± 1178 cells/mm2 compared with 5739 ± 394 cells/mm2 in the control group (P = 0.018). Age and duration of T2DM had no relationship with healing time (multiple linear regression, P = 0.618; P = 0.787). The density of LC in the T2DM group showed a negative correlation with SBN density (r = 0.350; R2 = 0.1225; P = 0.034). The density of SBN in the T2DM group showed a positive correlation with BEC density (r = 0.427; R2 = 0.1823; P = 0.008). The density of BEC in the T2DM group showed a negative correlation with healing time (r = 0.931; R2 = 0.8668; P = 0.001).ConclusionsUtilising IVCM, we have demonstrated increased LC and decreased SBN in patients with T2DM and CPE. Both may be related to lower BEC density and nuclei enhanced reflection. Furthermore, decreased BEC density may lead to delay in cornea epithelium healing in the T2DM group comparedwith controls. An immune-mediated response may play a role in delayed wound closure in patients with T2DM.

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“…Meibomian gland dysfunction (MGD) may also be involved [15]. Hope-Ross et al [16] observed a higher incidence of MGD in patients with RCE that are nontraumatic in origin.…”

Section: Pathogenesis Of Rcementioning

confidence: 99%

Recurrent Corneal Erosions in Corneal Dystrophies: a Review of the Pathogenesis, Differential Diagnosis, and Therapy

Omari

2018

Klin Monatsbl Augenheilkd

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Clinical Presentation and Causes of Recurrent Corneal Erosion Syndrome

Abstract: RCES has various etiologies, which explains the variety in the clinical presentation of the disorder. Interestingly, a significant number of RCES patients begin to manifest the syndrome after keratorefractive surgery, and a high percentage of patients also present with MGD.

Cited by 45 publications

References 13 publications

Topical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals

Topical Cross-Linked HA-Based Hydrogel Accelerates Closure of Corneal Epithelial Defects and Repair of Stromal Ulceration in Companion Animals

Epithelial changes with corneal punctate epitheliopathy in type 2 diabetes mellitus and their correlation with time to healing

Recurrent Corneal Erosions in Corneal Dystrophies: a Review of the Pathogenesis, Differential Diagnosis, and Therapy

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