Clinical presentation and imaging of general paresis due to neurosyphilis in patients negative for human immunodeficiency virus

Yu, Yanxin; Wei, Mengqi; Huang, Yuan-Gui; Jiang, Wen; Liu, Xuedong; Feng, Xia; Li, Deshuai; Zhao, Gang

doi:10.1016/j.jocn.2009.07.092

Cited by 22 publications

(13 citation statements)

References 8 publications

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“…Cerebral atrophy has frequently been found in neurosyphilis (Brightbill, Ihmeidan, Post, Berger, & Katz, 1995;Holland, Perrett, & Mills, 1986;Kodama et al, 2000;Luo et al, 2008;Peng et al, 2008;Yu et al, 2010;Zifko et al, 1996). Our finding of temporal lobe atrophy was also consistent with previous findings (Kodama et al, 2000;Yu et al, 2010).…”

Section: Discussionsupporting

confidence: 92%

“…Our finding of temporal lobe atrophy was also consistent with previous findings (Kodama et al, 2000;Yu et al, 2010). The MRA showed mild vascular pathology, including stenosis of cerebral arteries; this may be another pathology of neurosyphilis; infarction or arteritis (Brightbill et al, 1995;Holland et al, 1986;Luo et al, 2008;Peng et al, 2008;Smith & Anderson, 2000).…”

Section: Discussionsupporting

confidence: 91%

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Psychological/Cognitive Aspects in Untreated Neurosyphilis and Treatment with Penicillin G (A Case Study)

Muneoka

Kon²,

Kawabe³

et al. 2012

IJPS

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Active neurosyphilis is uncommon after the introduction of penicillin. We evaluated the pathology of a case of untreated neurosyphilis that was diagnosed as a manic episode. Examinations were performed before and after high-dose penicillin G treatment. Evaluations included the Mini-Mental State Examination (MMSE), the Neurobehavioral Cognitive Status Examination (Cognistat), the Bender Gestalt Test, an electroencephalogram, and brain magnetic resonance imaging/angiography. The most obvious improvements after treatment with penicillin G were the constructive ability and the ability to draw two-and three-dimensional designs. A paradoxical deterioration in several items on the Cognistat after treatment suggested an impairment in working memory. The clinical and psychological abnormalities observed in this case were speculated to be due to disturbed visual cognition related to encephalitis and impaired working memory related to temporofrontal lobe pathology. Current diagnostic tools were useful for precisely diagnosing and assessing the prognosis of older patients with late-onset mania

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Psychological/Cognitive Aspects in Untreated Neurosyphilis and Treatment with Penicillin G (A Case Study)

Muneoka

Kon²,

Kawabe³

et al. 2012

IJPS

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“…Abnormal EEG findings included background activity, diffuse abnormality, local abnormality and attack wave abnormality. Therefore, some scholars have suggested that EEG and MRI findings are valuable in the diagnosis of general paresis of NS [50]. …”

Section: Discussionmentioning

confidence: 99%

Clinical Spectrum of Neurosyphilis among HIV-Negative Patients in the Modern Era

et al. 2013

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Background: The clinical spectrum of neurosyphilis (NS) has changed over time. Objective: To describe the clinical spectrum and characteristics of NS in HIV-negative patients. Methods: A retrospective chart review was performed for 149 in patients with NS. Result: All patients were >25 years old, including 16.8% asymptomatic for NS, 15.4% with syphilitic meningitis, 24.2% with meningovascular NS, 38.9% with general paresis, 4.0% with tabes dorsalis and 0.7% with gummatous NS. The original misdiagnosis rate was 84.6%. All 149 patients had positive serum Treponema pallidum particle agglutination (TPPA) and rapid plasma reagin (RPR). The overall positive rates of cerebrospinal fluid RPR (CSF-RPR) and CSF-TPPA were 57.0 and 89.9%, respectively. CSF pleocytosis and elevated CSF protein were found in 40.3% of patients. Nonspecific abnormal brain magnetic resonance imaging and electroencephalography findings were present in 60.4 and 54.8% of NS patients, respectively. Conclusions: NS has various clinical manifestations, laboratory findings and magnetic resonance imaging and electroencephalography findings, but all studies lack specificity. Every patient with neurological or psychiatric symptoms that are without unambiguous causes should have blood tests for syphilis. When serology proves positive, patients should undergo CSF examination.

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“…A great number of publications focus on demential syndromes (e.g. Yu et al, 2010;Ates et al, 2009). Goeman and colleagues (1996) for example report in their survey on the occurrence of dementia symptoms in a 15-year-old boy with congenital syphilis.…”

Section: Psychiatric Manifestations Of Neurosyphilismentioning

confidence: 99%

Psychiatric Manifestations of Neurosyphilis

Friedrich¹,

Aigner²

2011

Syphilis - Recognition, Description and Diagnosis

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Clinical presentation and imaging of general paresis due to neurosyphilis in patients negative for human immunodeficiency virus

Cited by 22 publications

References 8 publications

Psychological/Cognitive Aspects in Untreated Neurosyphilis and Treatment with Penicillin G (A Case Study)

Psychological/Cognitive Aspects in Untreated Neurosyphilis and Treatment with Penicillin G (A Case Study)

Clinical Spectrum of Neurosyphilis among HIV-Negative Patients in the Modern Era

Psychiatric Manifestations of Neurosyphilis

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