Clinical Presentation and Mortality of Severe Fever with Thrombocytopenia Syndrome in Japan: A Systematic Review of Case Reports

Yokomizo, Kanako; Tomozane, Momoko; Sano, Chiaki; Ohta, Ryuichi

doi:10.3390/ijerph19042271

Cited by 18 publications

(10 citation statements)

References 32 publications

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“…Thrombocytopenia caused by urosepsis is also more common and is often detected early. Platelets can rebound after correction of sepsis, and thrombocytopenia may be associated with infection-mediated destruction [ 7 ]. Bone marrow suppression may be a factor in some septic patients [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Thromboelastography Parameters in Urosepsis: A Retrospective Study

Qiao

2022

Contrast Media & Molecular Imaging

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Thromboelastography (TEG) is usually used to monitor coagulation disorder clinically. It is unclear whether TEG has association with urosepsis and sepsis-induced coagulopathy (SIC). The purpose of this study was to investigate the clinical significance of TEG parameters in urosepsis. 90 patients who were admitted to the Emergency Ward and Emergency Intensive Care Unit (EICU) of Ren Ji Hospital affiliated to Shanghai Jiao Tong University School of Medicine due to urinary infection from February 2014 to February 2022 were retrospectively studied. Urosepsis patients and non-sepsis patients were separately investigated according to the final discharge diagnosis and Sepsis 3.0. At the same time, patients with urosepsis were further divided into groups of SIC and non-SIC based on the definition of SIC. The data of clinical features, laboratory biomarkers, and TEG parameters were collected and analyzed. There were significant differences in white blood cell count, C-reactive protein (CRP), platelet count, procalcitonin (PCT), fibrinogen (FIB), international normalized ratio (INR), prothrombin time (PT), D-dimer, and incidence of urinary tract obstruction between the urosepsis group and non-sepsis group ( P < 0.05 ). In the comparison with non-sepsis group, K value was significantly lower (P = 0.006), while α-angle ( P = 0.003 ) and clot index (CI) ( P = 0.048 ) were significantly higher in urosepsis group. The area under the K value curve excluding urosepsis was 0.667. The areas under CI and α-angle curves for diagnosing urosepsis were 0.682 and 0.621, respectively. The patients in SIC group had significantly higher K value, lower α-angle, and maximum amplitude (MA) than those in non-SIC group ( P < 0.05 ). Coagulopathy is prone to occur in patients with urosepsis. TEG is helpful for assessment of hypercoagulable state in urosepsis and prediction of hypocoagulability in SIC patients implying the dynamic process of DIC.

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Section: Discussionmentioning

confidence: 99%

[Retracted] Thromboelastography Parameters in Urosepsis: A Retrospective Study

Qiao

2022

Contrast Media & Molecular Imaging

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“…SFTS is a tick-borne zoonotic disease with a wide range of animal hosts and can cause high mortality in humans [ 10 , 26 , 27 ]. However, not until the first reported human SFTS fatal case in 2019 [ 25 ] was Taiwan considered as an endemic area.…”

Section: Discussionmentioning

confidence: 99%

The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan

Kuan

Lin

et al. 2023

Viruses

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Since the first discovery of severe fever with thrombocytopenia syndrome virus (SFTSV) in China in 2009, SFTSV has rapidly spread through other Asian countries, including Japan, Korea, Vietnam and Pakistan, in chronological order. Taiwan reported its first discovery of SFTSV in sheep and humans in 2020. However, the prevalence of SFTSV in domestic and wildlife animals and the geographic distribution of the virus within the island remain unknown. A total of 1324 animal samples, including 803 domestic ruminants, 521 wildlife animals and 47 tick pools, were collected from March 2021 to December 2022 from 12 counties and one terrestrial island. The viral RNA was detected by a one-step real-time reverse transcription polymerase chain reaction (RT-PCR). Overall, 29.9% (240/803) of ruminants showed positive SFTSV RNA. Sheep had the highest viral RNA prevalence of 60% (30/50), followed by beef cattle at 28.4% (44/155), goats at 28.3% (47/166), and dairy cows at 27.5% (119/432). The bovine as a total of dairy cow and beef cattle was 27.8% (163/587). The viral RNA prevalence in ticks (predominantly Rhipicephalus microplus) was similar to those of ruminants at 27.7% (13/47), but wild animals exhibited a much lower prevalence at 1.3% (7/521). Geographically the distribution of positivity was quite even, being 33%, 29.1%, 27.5% and 37.5% for northern, central, southern and eastern Taiwan, respectively. Statistically, the positive rate of beef cattle in the central region (55.6%) and dairy cattle in the eastern region (40.6%) were significantly higher than the other regions; and the prevalence in Autumn (September–November) was significantly higher than in the other seasons (p < 0.001). The nationwide study herein revealed for the first time the wide distribution and high prevalence of SFTSV in both domestic animals and ticks in Taiwan. Considering the high mortality rate in humans, surveillance of other animal species, particularly those in close contact with humans, and instigation of protective measures for farmers, veterinarians, and especially older populations visiting or living near farms or rural areas should be prioritized.

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“…Furthermore, to prevent acute exacerbation of JSF, more public education regarding JSF risks, presentation, and need for medical care is vital, particularly for older patients with JSF. Educating them about the disease's severity, potential complications, and care requirements can facilitate early detection and compliance with treatment protocols, especially in managing concurrent infections [ 13 , 14 ]. Early detection of the infection and prompt treatments are essential for quick recovery, addressing post-infection sequelae, and mitigating the chronic impacts of systemic bacterial infections [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Complicated Japanese Spotted Fever With Meningitis in an Older Patient: A Case Report

Amano,

Suyama,

Nishikura

et al. 2023

Cureus

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Japanese spotted fever (JSF) poses a significant public health challenge, mainly due to its atypical presentation in specific demographics. This report details a unique case of JSF in an 89-year-old female who was admitted to a rural hospital exhibiting generalized pain and rapid cognitive decline but no rash. Initially misdiagnosed as polymyalgia rheumatica, her condition was complicated by thrombocytopenia and altered mental state, prompting consideration of tick-borne illnesses. Subsequent serological analysis confirmed JSF despite the absence of its hallmark rash. The patient's condition escalated to include bacteremia and aseptic meningitis. Treatment involved a regimen of minocycline and meropenem, along with endoscopic cauterization of a bleeding rectal ulcer. After treatment, the patient showed improvement and was transferred for rehabilitation. This case highlights the criticality of considering JSF in elderly patients within endemic areas, even when classic symptoms like erythema and petechiae are absent. It underscores the necessity for broad diagnostic perspectives, especially in atypical presentations, and the integration of comprehensive care approaches. The involvement of caregivers and relatives in early detection and seeking medical care promptly is crucial. The report illustrates the complexities in diagnosing and managing advanced JSF cases and stresses the importance of early serological testing and adaptive treatment strategies in managing such challenging cases.

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Clinical Presentation and Mortality of Severe Fever with Thrombocytopenia Syndrome in Japan: A Systematic Review of Case Reports

Cited by 18 publications

References 32 publications

[Retracted] Thromboelastography Parameters in Urosepsis: A Retrospective Study

[Retracted] Thromboelastography Parameters in Urosepsis: A Retrospective Study

The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan

Complicated Japanese Spotted Fever With Meningitis in an Older Patient: A Case Report

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