Clinical Presentation and Outcome of Retinoblastoma among Children Treated at the National Cancer Institute (NCI) in Gezira, Sudan: A single institution experience

Ali, Amel A. E.; Elsheikh, Sara M. A.; Elhaj, Ahmed; Osman, Nada; Abuidris, Dafalla Omer; Eltayeb, Elgylani A.; Mahgoub, Maha; Hamdoun, Anas; Babiker, M; Mohamedani, Ahmed Abdalla; Elwali, Nasr Eldin; Qaddoumi, Ibrahim

doi:10.3109/13816810.2010.546822

Cited by 39 publications

(46 citation statements)

References 16 publications

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“…La edad media de presentación del retinoblastoma es de 15 meses 11 . En paí-ses con bajo nivel de desarrollo 12,13 , los signos iniciales al momento del consulta cambian, siendo la primera causa de consulta la proptosis (55%) o el buftalmos (56%). La mayoría de nuestros casos con antecedentes familiares de retinoblastoma fueron bilaterales, lo que es concordante con la literatura 14 .…”

Section: Discussionunclassified

Manejo multidisciplinario en retinoblastoma: experiencia en 37 ojos

Ossandón

Zanolli

Pérez

et al. 2015

Archivos de la Sociedad Española de Oftalmología

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Section: Discussionunclassified

Manejo multidisciplinario en retinoblastoma: experiencia en 37 ojos

Ossandón

Zanolli

Pérez

et al. 2015

Archivos de la Sociedad Española de Oftalmología

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“…On the other extreme, presentations of retinoblastoma differ. From Sudan 9 , buphthalmos (56%) and leukocoria (32%) were most common, and from Mali in Africa 10 , proptosis (55%), leukocoria (38%), strabismus (6%), and buphthalmos (2%) were found. Efforts are underway internationally to educate clinicians, nurses, patients, and entire populations for improvement in retinoblastoma detection.…”

Section: Clinical Features Of Retinoblastomamentioning

confidence: 99%

Erratum: Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy

Shields¹,

Fulco²,

Arias³

et al. 2012

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In this report, we explore retinoblastoma diagnostic accuracy and review chemotherapy alternatives for retinoblastoma using intravenous, intra-arterial, periocular, and intravitreal routes. A review of 2775 patients referred for management of retinoblastoma, disclosed 78% with confirmed retinoblastoma and 22% with simulating lesions, termed pseudoretinoblastomas. Children r2 years old showed leading pseudoretinoblastomas of persistent fetal vasculature, Coats disease, and vitreous haemorrhage, whereas those 45 years showed simulators of Coats, toxocariasis, and familial exudative vitreoretinopathy. The diagnosis of retinoblastoma should be established before planning therapeutic strategy. Chemotherapy strategy depends on tumour laterality and stage of disease. If bilateral retinoblastoma, intravenous chemotherapy (IVC) is important as first-line therapy for control of intraocular disease, prevention of metastasis, and reduction in prevalence of pinealoblastoma and long-term second malignant neoplasms. Bilateral groups D and E retinoblastoma receive additional subtenon's carboplatin boost for improved local control. If unilateral disease is present, then intra-arterial chemotherapy (IAC) is often considered. IAC can be salvage therapy following chemoreduction failure. Unilateral retinoblastoma of groups D and E are managed with enucleation or globeconserving IVC and/or IAC. Intravitreal chemotherapy is cautiously reserved for recurrent vitreous seeds following other therapies. In conclusion, the strategy for retinoblastoma management with chemotherapy depends on tumour laterality and stage of disease. Bilateral retinoblastoma is most often managed with IVC and unilateral retinoblastoma with IAC, but if advanced stage, combination IVC plus IAC or enucleation.

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“…Namibia D2 = 3.5 months, n = 15 (Wessels1996) [25]. Sudan D1 = 10 months, n = 25 (Ali2011) [26]. Burkina Faso, D1 = 11 months, n = 3 (Nikiema2009) [27].…”

Section: Introductionmentioning

confidence: 99%

Integrating stages of change models to cast new vision on interventions to improve global retinoblastoma and childhood cancer outcomes

2014

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BackgroundRetinoblastoma, the most common intraocular tumor globally, represents a curable cancer when diagnosed early and treated promptly. Delay to diagnosis, lag time prior to treatment initiation, and abandonment of treatment including upfront treatment refusal, represent stark causes of high retinoblastoma mortality rates in low- and middle- income settings, particularly regions in Africa. While a health delivery-based approach has been a historic focus of retinoblastoma treatments globally and is essential to quality care, this is necessary but not adequate. Retinoblastoma is a compelling disease model to illustrate the potential insights afforded in theory-informed approaches to improve outcomes that integrate public health and oncology perspectives, prioritizing both health service delivery and social efficacy for cure.DiscussionGiven that barriers to appropriate and timely diagnosis and treatment represent main contributors to mortality in children with retinoblastoma in resource-limited settings such as certain areas in Africa, an important priority is to overcome barriers to cure that may be predominantly socially influenced, alongside health delivery-based improvements. While Stages of Change models have been effectively utilized in cancer screening programs within settings of economic and cultural barriers, this application of health behavior theory has been limited to cancer screening rather than a comprehensive framework for treatment completion. Using retinoblastoma as a case example, we propose applying stage-based intervention models in critical stages of care, such as the Precaution Adoption Process Model to decrease delay to diagnosis and a Transtheoretical Model to increase treatment completion rates in resource-limited settings.SummaryStage-based theories recognize that improved cure and survival outcomes will require supportive strategies to progress households, communities, and social and economic institutions from being unaware and unengaged to committed and sustained in their respective roles. Applying a stage-based model lens to programmatic interventions in resource-limited settings has potential for visible improvement in outcomes for children with retinoblastoma and other cancers.

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Clinical Presentation and Outcome of Retinoblastoma among Children Treated at the National Cancer Institute (NCI) in Gezira, Sudan: A single institution experience

Abstract: Although these findings are not surprising, and similar to reports from other developing countries, we hope our work will provide a foundation for strategies to improve outcome for retinoblastoma in our center such as proper training, public awareness, team approach, and twinning.

Cited by 39 publications

References 16 publications

Manejo multidisciplinario en retinoblastoma: experiencia en 37 ojos

Manejo multidisciplinario en retinoblastoma: experiencia en 37 ojos

Erratum: Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy

Integrating stages of change models to cast new vision on interventions to improve global retinoblastoma and childhood cancer outcomes

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