Clinical Presentation and Outcomes of Kawasaki Disease in Children from Latin America: A Multicenter Observational Study from the REKAMLATINA Network

Narayan, Hari K.; Lizcano, Anel; Lam-Hine, Tracy; Ulloa‐Gutiérrez, Rolando; Bainto, Emelia; Garrido-Garcı́a, Luis Martı́n; Estripeaut, Dora; Águila, Olguita del; Gómez, Virgen; Faugier-Fuentes, Enrique; Miño-León, Greta; Beltrán, Sandra; Cofré, Fernanda; Chacón-Cruz, Enrique; Saltigeral-Simental, Patricia; Martínez-Medina, Lucila; Dueñas, Lourdes; Luciani, Kathia; Rodriguez-Quiroz, F.; Moreno, Germán Camacho; Viviani, Tamara; Álvarez-Olmos, Martha I.; Marques, Heloísa Helena de Sousa; López‐Medina, Eduardo; Pírez, María Catalina; Tremoulet, Adriana H.; Gámez-González, Luisa Berenise; Patiño, Jaime; Cleves, Daniela; Franco‐Martínez, Lorena; Ávila-Agüero, María Luisa; Camacho-Badilla, Kattia; Soriano-Fallas, Alejandra; Li-Chan, Susan; Valverde, Kathia; Ellis, Alejandro; Grazioso, Carlos; Grazioso, Pablo J.; Calvimontes, Gonzalo; Izquierdo, Giannina; Picart, Pilar; Salgado, Andrea; Borzutzky, Arturo; Arbo, Antonio; Lovera, Dolores; Amarilla, Sara; F, Galeano; Astigarraga, Norma; Luis-Álvarez, Maria del Carmen; Fynn, Estefanía; Assandri, Elizabeth; Levy, Jacqueline; Castaño, Elizabeth; Esquivel, R.; Norero, Ximena; Sinisterra, Scarlet; Daza, Carlos Enrique; Record, Javier; Hurtado-Palacios, Isabel C.; Madrid, Antonio Hernández; Calvache-Burbano, Angélica; Fernández, Antonio; Sánchez, Yasmín; Freire, Dolores; Yamazaki‐Nakashimada, Marco Antonio; Rodríguez-Herrera, Raymundo; López-Gallegos, Diana; Márquez-González, Horacio; Marquez-Herrera, Kelly; Sakita, Neusa Keico; Pereira, Maria Fernanda Bádue; Leal, Gabriela Nunes; Guarnizo, Pilar; Huertas-Quiñones, Manuel; López, Pío; Deseda-Tous, Jaime; Pujadas, Mónica; Soza, Guillermo; Cerda, C; López-Medina, Issa Lorena; Hernández-Magaña, Rafael; Passos, Saulo Duarte; Rubio-Pérez, Nadina; García-Rodríguez, Fernando M.; Martínez-Ramírez, Rogelio; Rodríguez-Muñoz, Lorena; Flores-Hernández, Karina; Díaz-Díaz, Alejandro; Mesa-Monsalve, Juan Gonzalo; Somarriba, María Mercedes; Lara-Huerta, Jesús de

doi:10.1016/j.jpeds.2023.02.001

The Journal of Pediatrics

2023

DOI: 10.1016/j.jpeds.2023.02.001

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Clinical Presentation and Outcomes of Kawasaki Disease in Children from Latin America: A Multicenter Observational Study from the REKAMLATINA Network

Hari K. Narayan

Anel Lizcano²,

Tracy Lam-Hine³

et al.

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Cited by 3 publications

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“…[ 3 ] A recent multicentre study in Latin America revealed that up to 21% of the KD patients had CAA detected during their follow-up. [ 4 ] Remarkably, prior to the use of IVIG, the rate of CAA regression was 55% in the first 2 years of KD, whereas it is currently 75% with the use of IVIG. [ 5 , 6 ] Additionally, only 19% of patients with giant CAA (z-score ≥10) at the time of diagnosis experienced regression, and up to 5% of these patients may experience severe cardiovascular events.…”

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confidence: 99%

Kawasaki Disease: A Never-ending Story?

et al. 2023

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The most severe complication of Kawasaki disease, an inflammatory disorder of young children, is the formation of coronary artery aneurysms. It is known that patients with coronary artery aneurysms, particularly those with medium and large lesions, have a higher risk of future major cardiovascular events. In contrast, there is a lack of data on the cardiovascular status in long-term follow-up for Kawasaki disease patients without coronary involvement or with self-limited coronary artery aneurysms, resulting in most patients being discharged after 5 years. Even though some paediatricians may believe these patients should not be followed at all, studies indicating a dysfunctional endothelium show the need for further investigation. Consequently, a review of the most significant aspects of Kawasaki disease, and the necessity of correctly identifying, treating and monitoring these patients, particularly those with a higher risk of complications, was conducted.

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confidence: 99%

Kawasaki Disease: A Never-ending Story?

et al. 2023

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Impact of social determinants of health on the outcomes of Latin American children with Multisystem Inflammatory Syndrome (MIS‐C)

Buonsenso,

Camporesi,

Sawaya

et al. 2024

Pediatric Pulmonology

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ImportanceThere is growing understanding that Social Determinants of Health (SDH) impact on the outcomes of different pediatric conditions. We aimed to determine whether SDH affect the severity of MIS‐C.DesignRetrospective cohort study, 2021–2023. Children and adolescents with MIS‐C younger than 18 years of age fulfilling the MIS‐C CDC definition within the REKAMLATINA network were invited to participate. We assessed the impact of SDH on the risk of children with MIS‐C to be diagnosed with shock, need of inotropes, respiratory support, transfusion, and death.ResultsTwo hundred and seventy seven patients from 30 centers in 13 countries were included. Of them, 241 children from the four most‐represented countries were included in the final analysis. Food insecurity, higher distance from a health center, not possessing a private vehicle to transport the patient to hospital, and having a home in poor condition, were associated with low LVEF, need of transfusion, shock, and need for respiratory support, when controlling for age, BMI, and ethnicity. The Score of Social Disadvantage was associated with Shock (OR: 1.35, P: 0.011, 95% CI: 1.07–1.71), Respiratory support (OR: 1.39, P: 0.005, 95% CI: 1.1–1.75), Transfusion (OR: 1.63, P0.013, 95% CI 1.1–2.41), but not death (OR: 0.76, P: 0.38, 95% CI: 0.41–1.40).ConclusionsAmong a large cohort of Latin American children with MIS‐C, SDH negatively affect outcomes. These findings reinforce the need for better investigation of the role of SDH in MIS‐C and other inflammatory conditions and may guide public health interventions.

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A prediction model for coronary artery abnormalities in children with Kawasaki disease older than 5 years

Yang,

Zhang,

Chen

et al. 2024

Jornal de Pediatria

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Clinical Presentation and Outcomes of Kawasaki Disease in Children from Latin America: A Multicenter Observational Study from the REKAMLATINA Network

Cited by 3 publications

References 20 publications

Kawasaki Disease: A Never-ending Story?

Kawasaki Disease: A Never-ending Story?

Impact of social determinants of health on the outcomes of Latin American children with Multisystem Inflammatory Syndrome (MIS‐C)

A prediction model for coronary artery abnormalities in children with Kawasaki disease older than 5 years

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