Clinical presentation and pulmonary function tests in post-acute COVID-19 patients

Genzor, Samuel; Jakubec, Petr; Sova, Milan; Mizera, Jan; Joppa, Pavol; Bürget, Radim; Pobeha, Pavol

doi:10.5507/bp.2022.039

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…In a recent study by Genzor et al [ 11 ], we evaluated the post-COVID symptoms in post-acute COVID-19 individuals ( N = 785). Dyspnea was present more frequently in more severe forms and persisted in 40% of patients after mild COVID-19, which was significantly less than 63.7% after aa severe COVID-19 course.…”

Section: Introductionmentioning

confidence: 99%

Post-COVID Syndrome and Cardiorespiratory Fitness—26-Month Experience of Single Center

Sova

Sovová

Ožana

et al. 2023

Life

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Introduction: Persistent post-COVID syndrome, also referred to as long COVID, is a pathologic entity that involves persistent physical, medical, and cognitive sequelae following COVID-19. Decreased fitness has repeatedly been reported in numerous studies dealing with post-COVID syndrome, however, it is still not fully clear which groups of patients may be more susceptible for persisting symptoms. Aim: The aim of our study was to evaluate the number of post-COVID patients with cardiac symptoms, where these patients were evaluated by CPET and the results compared with a control group of patients. Methods: Follow-up of patients in post-COVID outpatient clinic from 1 March 2020 to 31 May 2022. Inclusion criteria were positive PCR test for SARS-CoV-2 and age 18–100. The initial examination was performed 4–12 weeks after the disease onset. All patients with possible cardiac symptoms had completed cardiopulmonary exercise testing. The control group was randomly selected from a database of clients in 2019, with the preventive reason for evaluation. Results: From 1 March 2020 to 31 May 2022, 2732 patients (45.7% males) were evaluated with a mean age of 54.6 ± 14.7. CPET was indicated only in 97 patients (3.5%). Seventy-four patients (26 male) achieved the exercise maximum and a comparison were made with a control group (same age (p = 0.801), BMI (p = 0.721), and sex ratio). No significant dependence between the parameter VO2 max mL/kg/min and post-COVID disability was demonstrated (p = 0.412). Spearman’s correlation analysis did not show a significant relationship between the parameter VO2 max mL/kg/min and the severity of COVID-19 (p = 0.285). Conclusions: Cardiac symptoms occurred in only a small percentage of patients in our study. There is a need for further studies that would objectively evaluate the effect of COVID-19 disease on the patient’s health.

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Section: Introductionmentioning

confidence: 99%

Post-COVID Syndrome and Cardiorespiratory Fitness—26-Month Experience of Single Center

Sova

Sovová

Ožana

et al. 2023

Life

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Long-Term Follow-Up of Patients Needing Extracorporeal Membrane Oxygenation Following a Critical Course of COVID-19

Genzor

Pobeha

Šimek

et al. 2023

Life

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Introduction: Severe respiratory failure is one of the most serious complications of coronavirus disease 2019 (COVID-19). In a small proportion of patients, mechanical ventilation fails to provide adequate oxygenation and extracorporeal membrane oxygenation (ECMO) is needed. The surviving individuals need long-term follow-up as it is not clear what their prognosis is. Aim: To provide a complex clinical picture of patients during follow-up exceeding one year after the ECMO therapy due to severe COVID-19. Methods: All subjects involved in the study required ECMO in the acute stage of COVID-19. The survivors were followed-up for over one year at a specialized respiratory medical center. Results: Of the 41 patients indicated for ECMO, 17 patients (64.7% males) survived. The average age of survivors was 47.8 years, and the average BMI was 34.7 kg·m−2. The duration of ECMO support was 9.4 days. A mild decrease in vital capacity (VC) and transfer factor (DLCO) was observed on the initial follow-up visit (82.1% and 60%, respectively). VC improved by 6.2% and by an additional 7.5% after 6 months and 1 year, respectively. DLCO improved by 21.1% after 6 months and remained stable after 1 year. Post-intensive care consequences included psychological problems and neurological impairment in 29% of patients; 64.7% of the survivors got vaccinated against SARS-CoV-2 within 12 months of hospitalization and 17.6% experienced reinfection with a mild course. Conclusion: The COVID-19 pandemic has significantly increased the need for ECMO. Patients’ quality of life after ECMO is temporarily significantly reduced but most patients do not experience permanent disability.

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Clinical presentation and pulmonary function tests in post-acute COVID-19 patients

Cited by 2 publications

References 25 publications

Post-COVID Syndrome and Cardiorespiratory Fitness—26-Month Experience of Single Center

Post-COVID Syndrome and Cardiorespiratory Fitness—26-Month Experience of Single Center

Long-Term Follow-Up of Patients Needing Extracorporeal Membrane Oxygenation Following a Critical Course of COVID-19

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