Clinical Presentation and Treatment of Gastrointestinal Stromal Tumors

Abstract

Results:The patients with localized disease treated only by surgery did not relapse. In the patients with locally advanced or metastatic disease treated by imatinib, we observed 3 partial responses, and one case was not assessable because he had no measurable disease. In 2 of 3 responders, it was possible to perform a new radical surgery. Conclusions: Our series is too small to draw any conclusion. According to our review of the literature, surgery remains the standard treatment for non-metastatic GISTs. Imatinib mesylate represents a major breakthrough in the treatment of advanced GISTs and is the first effective systemic therapy for the disease.

Gastrointestinal stromal tumor of rectum

“…Complete surgical resection with negative margins is curative for primary and non-metastatic low risk tumors 6,[16][17][18] . Local excision, anterior resection or abdomino-perineal resection for rectal GIST depends on tumor size and location 15,19 .…”