Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study

The relevance of multiple clinical specimens in the diagnosis of monkeypox virus, Spain, June 2022

“…In a previous report, blood samples were tested in two patients on different days and also showed high Cq values [ 6 ]. To our knowledge, there is a lack of evidence about the detection of MPXV DNA in blood samples and its epidemiological and clinical significance [ 7 , 8 ].…”

The changing face of monkeypox

“…9 This pattern enables vaccine prioritisation, which may need flexibility if and when new at risk groups emerge. 10 Vaccination must be delivered sensitively to avoid the kind of stigmatising public health messaging used early in the HIV epidemic. Creative approaches will be needed to ensure equitable distribution to people at risk who have poorer access to services or health literacy, both in the UK and globally.…”

Early estimates of the incidence trend and the reproductive number of the monkeypox epidemic in Brazil

“…However, it is important to highlight that these two infectious agents have significantly different profiles of transmission. Monkeypox transmission appears to mainly occur by direct contact in the current outbreak, which can be related to a high viral load on skin lesions (22,23). Moreover, there is evidence of a lesion staying positive on the PCR test for up to 21 days (24).…”

“…We observed that the Rt of the four analyzed states may be comparable with some calculated for covid-19 (9). Monkeypox transmission appears to mainly occur by direct contact in the current outbreak (10) has a high viral load on skin lesions (11) and there is evidence of a lesion staying positive on the PCR test for up to 21 days (12). We hypothesize that a prolonged infectious period could explain those Rt values.…”