Clinical presentation of celiac disease among pediatric compared to adolescent and adult patients

Abstract

Pediatric patients of CD present more often with typical features than adults. Atypical presentations are more common in adults and the latent period for diagnosis is also longer in adolescent/adults. There is a need for increasing awareness about CD, both among pediatricians and physicians caring for adult patients.

Anemia in celiac disease is multifactorial in etiology: A prospective study from India

“…In population‐based studies from North America and Europe, anemia was seen in 35 and 53% patients of CD, respectively, and in 20–80% patients from Middle Eastern and North African populations . However, studies from India have reported an even higher prevalence of anemia in patients with CD . In our study, symptoms suggestive of anemia were the presenting feature in 74 patients (71.8%), but on investigation, anemia was seen in 96 patients (93.2%).…”

“…The prevalence of anemia in CD is highly variable in different age groups and geographic locations. The prevalence is higher in developing countries (>80%) compared to developed ones (5–40%), and the prevalence is higher in adults than in children . In population‐based studies from North America and Europe, anemia was seen in 35 and 53% patients of CD, respectively, and in 20–80% patients from Middle Eastern and North African populations .…”

Deficiencia de hierro y anemia ferropénica. Guía para su prevención, diagnóstico y tratamiento. Texto completo

“…63 -Error diagnóstico: Si bien la ferropenia es la principal causa de anemia microcítica en la infancia, frente al fracaso terapéutico, se deben plantear alternativas diagnósticas posibles (véase Anemias microcíticas hipocrómicas: guía de diagnóstico diferencial).…”

Issues associated with the emergence of coeliac disease in the Asia–Pacific region: A working party report of the World Gastroenterology Organization and the Asian Pacific Association of Gastroenterology

“…Its manifestations vary and have been reviewed elsewhere . The more common manifestations are as follows: Anemia is common and several studies from Europe, North America, and India have suggested that iron deficiency with or without anemia may be the sole manifestation of CD . While iron deficiency is the commonest cause of anemia, untreated subjects with CD can have folic acid and, less commonly, vitamin B12 deficiency …”

“…• Hematological manifestations: Anemia is common and several studies from Europe, North America, and India have suggested that iron deficiency with or without anemia may be the sole manifestation of CD. 3,40,43,[48][49][50] While iron deficiency is the commonest cause of anemia, untreated subjects with CD can have folic acid and, less commonly, vitamin B12 deficiency. 50,51 • Endocrinological manifestations: Although CD is a known cause of short stature/failure to thrive, it has been poorly recognized in many countries including India.…”