Clinical presentation of childhood soft tissue sarcomas: a systematic review and meta-analysis
Lorna Ni Cheallaigh,
Jo-Fen Liu,
Lorna Fern
et al.
Abstract:BackgroundTime to diagnosis (TTD) of childhood soft tissue sarcoma (STS) is significantly associated with survival. This review aims to identify pre-diagnostic symptoms/signs to inform earlier diagnosis interventions.MethodsMedline, Embase, Cochrane and Web-of-Science were searched between January 2010 and February 2021 for studies including children (<18 years) diagnosed with STS, with no language restrictions. Pooled proportions of symptoms/signs were calculated and subanalysed by tumour location and age.… Show more
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