Clinical Presentation of Community-Acquired Chlamydia pneumoniae Pneumonia in Adults

Miyashita, Naoyuki; Fukano, Hiroshi; Okimoto, Niro; Hara, Hiroki; Yoshida, Koichiro; Niki, Yoshihito; Matsushima, Toshiharu

doi:10.1378/chest.121.6.1776

Cited by 55 publications

(72 citation statements)

References 18 publications

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“…Our two female patients with TWAR CAP presented mild clinical diseases, similar to reported cases [12,13]. Both diseases had a subacute course with symptoms for more than one week before hospitalization.…”

Section: Discussionsupporting

confidence: 88%

“…In our third case both Gram stain and culture of sputum samples obtained before antibioticotherapy don´t suggest concomitant pneumococcal infection. The mild severity of our clinical cases suggests TWAR etiology only, according to former reports showing that C. pneumoniae CAP is milder than pneumococcal pneumonia [12,13]; and that pneumonia due to concomitant infection with C. pneumoniae and S. pneumoniae results in a more severe illness than did TWAR infections alone [15]. As we did not exclude other etiological agents, we cannot attribute the etiology of our CAP cases to TWAR only.…”

Section: Discussionmentioning

confidence: 50%

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Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Chedid¹,

Chedid²,

Ilha³

et al. 2007

Braz J Infect Dis

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As there was not any data on Chlamydia pneumoniae (TWAR) infections in Brazil so far, a prospective cohort study of adult patients hospitalized due to CAP was carried out for one year in a Brazilian university general hospital to detect the incidence of CAP by Chlamydophila pneumoniae (TWAR) for one year. During a whole year 645 consecutive patients hospitalized due to an initial presumptive diagnosis of respiratory diseases by ICD-10 (J00-J99), excluding upper respiratory diseases, were screened; 59 consecutive patients with CAP were diagnosed. They had determinations of serum antibodies to C. pneumoniae by microimmunofluorescence at the Infectious Diseases Laboratory of University of Louisville (KY, USA); 37 patients (63.8%) had seroreactivity to TWAR antigens, from which 23 (39.6%) had previous infection; 3 patients (5.2%) were diagnosed with CAP by TWAR and got cured. The incidence of TWAR CAP in our hospital by seroconversion was 5.2%. Our incidence of 5.2% is probably underestimated since TWAR culture was not available; we suggest that Real-Time PCR be used along with other diagnostic methods in future studies to detect the actual incidence of TWAR CAP. We propose that the serological criterion of IgM ≥1:16 alone to the diagnosis of acute infection by TWAR are discontinued due a lack of specificity.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 50%

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Chedid¹,

Chedid²,

Ilha³

et al. 2007

Braz J Infect Dis

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“…These specimens were also used for culturing of M. pneumoniae and Legionella species on pleuropneumonia-like organism broth and agar (70% pleuropneumonia-like organism broth [Difco, Inc., Detroit, MI, USA] supplemented with 20% heat-inactivated horse serum, 10% fresh yeast extract [25%], thallium acetate [final concentration 0.5 mg/mL], and sterile penicillin G [final concentration 1,000 U/mL]) and buffered charcoalyeast extract alpha agar, respectively. Cultures for Chlamy-dophila pneumoniae and C. psittaci were performed using cycloheximide-treated HEp-2 cells grown in a 24-well cell culture plate [16]. All specimens were passed twice.…”

Section: Microbiological Laboratory Testsmentioning

confidence: 99%

“…A microimmunofluorescence test was used for the titration of IgG and IgM antibodies against chlamydial species, using formalinized elementary bodies of C. pneumoniae KKpn-15, C. trachomatis L2/434/Bu, and C. psittaci Budgerigar-1 strains as antigens [16]. Rheumatoid factors were absorbed with GullSORB (Meridian Bioscience Inc., OH, USA) before IgM titrations.…”

Section: Microbiological Laboratory Testsmentioning

confidence: 99%

Radiographic Features of Mycoplasma Pneumoniae Pneumonia: Differential Diagnosis and Performance Timing

Miyashita

Sugiu

Kawai

et al. 2009

Chest

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“…He had no prulent sputum production and had not undergone a physical examination of the chest. WBCcount revealed a mild elevation (6). He was treated with minocycline (200 mg/day) for two weeksand both his symptoms, except for the cough, and chest radiograph improved.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Pneumonia due to Persistent Chlamydia Pneumoniae Infection.

et al. 2002

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Twocases of recurrent pneumoniadue to Chlamydia pneumoniae are described. C. pneumoniae was continuously detected from the nasopharynx in both patients by the polymerase chain reaction and/or culture even with appropriate antibiotic therapy during the first episode. After eradication of C. pneumoniae with long-term macrolide therapy, the respiratory symptoms of both patients completely disappeared and no relapse was observed. These data indicate that newtreatment strategies maybe necessary to eradicate the organism in patients prone to persistent infection. (Internal Medicine 41 : 30-33, 2002)

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Clinical Presentation of Community-Acquired Chlamydia pneumoniae Pneumonia in Adults

Cited by 55 publications

References 18 publications

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Community-acquired pneumonia by Chlamydophila pneumoniae: a clinical and incidence study in Brazil

Radiographic Features of Mycoplasma Pneumoniae Pneumonia: Differential Diagnosis and Performance Timing

Recurrent Pneumonia due to Persistent Chlamydia Pneumoniae Infection.

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