Clinical presentation, therapeutic approach and outcome of primary cutaneous marginal zone B‐cell lymphoma presenting as AL amyloidoma of the skin

Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates

“…Sixty-three relevant articles assessing kappa and lambda IHC or ISH in the evaluation of an atypical cutaneous or mucosal lymphoid infiltrate were identified ( Table 1, Table S1). 5,[9][10][11][12][13][14][15][16][17][18] 44 papers evaluated IHC exclusively, 10,11,13,15,17,[22][23][24][25][26][27][28][29]31,32,34,35,37,40,42,45,46,[48][49][50][52][53][54][55][57][58][59][60][61][62][63][64][65][66]…”

“…5,12,14,33,36,38,39,41,51,56 Two studies examined frozen tissue only, 58,65 five studies used frozen and FFPE tissue, 25,35,49,61,62 one study used formalin-or glutaraldehydefixed, paraffin-embedded tissue, 28 one study used formalin or B5-fixed, paraffin-embedded tissue, 50 one study used formalin or Zenker's fixed paraffin-embedded tissue, 71 one study used formalin and B5-fixed paraffin-embedded tissue and frozen tissue, 67 three studies did not specify fixation, 47,70,73 and the remainder utilized FFPE tissue. 5,[9][10][11][12][13][14][15][16][17][18][22][23][24]26,27,[29][30][31][32][33][34][36][37]…”

“…Figure 1A-F). 5,9,11,13,14,[16][17][18][22][23][24][28][29][30][31][32][33]35,38,39,41,43,44,49,50,[52][53][54]58,[60][61][62][63][64]66,68,69,72,73 16 papers exclusively examined primary cutaneous marginal zone lymphoma with kappa and lambda IHC/ISH, including lesions termed immunocytomas, amyloidomas, primary cutaneous plasmacytomas, and cutaneous follicular lymphoid hyperplasia with monotypic plasma cells. 13,14,18,24,29,30,32,43,44,[52][53]…”

“…72 The clinical impression was not included in many studies. 5,12,14,16,23,[28][29][30][31][32][33][34][35]37,38,41,43,46,47,[49][50][51][52][56][57][58]60,[65][66][67][69][70][71][72][73] 4 | DISCUSSION Flow cytometry (FC) also detects light chain restriction. It is often used to detect surface light chain, but can be used to detect cytoplasmic light chain following a permeabilization procedure.…”

“…Unfortunately, many studies do not specify the kappa and lambda ratio that was used to determine light chain restriction. [23][24][25][26][28][29][30][31][32][34][35][36][38][39][40][42][43][44][45][47][48][49][50][51][52][53][54][55][57][58][59][62][63][64][65][66][68][69][70][71]73 Complicating matters, universally accepted standards for kappa to lambda ratios that signify light chain restriction and monotypia have not been established.…”