Clinical presentations and epidemiology of β-haemolytic streptococcal bacteraemia: a population-based study

Rantala, Sari; Vuopio‐Varkila, Jaana; Vuento, Risto; Huhtala, Heini; Syrjänen, Jaana

doi:10.1111/j.1469-0691.2008.02672.x

Cited by 71 publications

(80 citation statements)

References 21 publications

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“…Many previous epidemiologic studies of human infection by GCGS failed to detect S. canis (28,44,45). In Portugal, an ongoing survey of human infections by large-colony-forming GCGS did not detect any S. canis isolates prior to 2005, while over 300 S. dysgalactiae subsp.…”

Section: Discussionmentioning

confidence: 99%

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp.equisimilis

Pinho

Matos

Pomba³

et al. 2013

J Clin Microbiol

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dStreptococcus canis is an animal pathogen that occasionally causes human infections. Isolates recovered from infections of animals (n ‫؍‬ 78, recovered from 2000 to 2010 in three European countries, mainly from house pets) and humans (n ‫؍‬ 7, recovered from 2006 to 2010 in Portugal) were identified by phenotypic and genotypic methods and characterized by antimicrobial susceptibility testing, multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), and emm typing. S. canis isolates presented considerable variability in biochemical profiles and 16S rRNA. Resistance to antimicrobial agents was low, with the most significant being tet(M)-and tet(O)-mediated tetracycline resistance. MLST analysis revealed a polyclonal structure of the S. canis population causing infections, where the same genetic lineages were found infecting house pets and humans and were disseminated in distinct geographic locations. Phylogenetic analysis indicated that S. canis was a divergent taxon of the sister species Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis and found evidence of acquisition of genetic material by S. canis from S. dysgalactiae subsp. equisimilis. PFGE confirmed the MLST findings, further strengthening the similarity between animal and human isolates. The presence of emm-like genes was restricted to a few isolates and correlated with some MLST-based genetic lineages, but none of the human isolates could be emm typed. Our data show that S. canis isolates recovered from house pets and humans constitute a single population and demonstrate that isolates belonging to the main genetic lineages identified have the ability to infect the human host, providing strong evidence for the zoonotic nature of S. canis infection.

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Section: Discussionmentioning

confidence: 99%

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp.equisimilis

Pinho

Matos

Pomba³

et al. 2013

J Clin Microbiol

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“…Large-colony group C and G streptococci (Streptococcus dysgalactiae subsp. equisimilis) are also important causes of communityonset BSI, with incidence rates of approximately 2 to 3 per 100,000 observed in Canada, Denmark, and Finland (5,(172)(173)(174).…”

Section: Specific Etiologiesmentioning

confidence: 99%

Population-Based Epidemiology and Microbiology of Community-Onset Bloodstream Infections

2014

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SUMMARY Bloodstream infection (BSI) is a major cause of infectious disease morbidity and mortality worldwide. While a positive blood culture is mandatory for establishment of the presence of a BSI, there are a number of determinants that must be considered for establishment of this entity. Community-onset BSIs are those that occur in outpatients or are first identified <48 h after admission to hospital, and they may be subclassified further as health care associated, when they occur in patients with significant prior health care exposure, or community associated, in other cases. The most common causes of community-onset BSI include Escherichia coli , Staphylococcus aureus , and Streptococcus pneumoniae . Antimicrobial-resistant organisms, including methicillin-resistant Staphylococcus aureus and extended-spectrum β-lactamase/metallo-β-lactamase/carbapenemase-producing Enterobacteriaceae , have emerged as important etiologies of community-onset BSI.

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“…infections by GGS had positive blood cultures as seen by other workers [2,[4][5][6] as high as 41% (128/314 cases) as reported by [6]. A history of skin infections/disruption of skin barrier [2][3][4][5][6] was seen in twothirds cases of GGS bacteremias 53% being second only to Group A streptococcus 58% infections [6] Group C streptococcus Large colony generally include several species like S. Dysgalactae, S. equisimilis, S. zooepidemicus and S. equi [7].…”

Section: Introductionmentioning

confidence: 77%

“…A history of skin infections/disruption of skin barrier [2][3][4][5][6] was seen in twothirds cases of GGS bacteremias 53% being second only to Group A streptococcus 58% infections [6] Group C streptococcus Large colony generally include several species like S. Dysgalactae, S. equisimilis, S. zooepidemicus and S. equi [7]. Average length of stay for all diabetic patients with GGS infections all over the body was longer (14.6) days than those who were not having diabetes mellitus [6]. DeBrahandre's case was discharged after 17 days [1] which although was drained laparoscopically while our case underwent emergency diagnostic laparoscopy and converted to open exploratory laparotomy with a prompt follow up and up-gradation of antibiotics in response to further liquid subcultures and our case was discharged on post-operative day 10.…”

Section: Introductionmentioning

confidence: 99%

“…Another thing is that the routine 48 hours culture trend as done in smaller centres would have missed this bacterium altogether. It is reported in literature that there is an increasing incidence of GGS infections either due to increased reporting, vigilant microbiologists or increasing virulence [3,4,6]. Whether this is representing an emerging new trend of pathogenicity in an apparently non-pathogenic organism where the pet is now biting the hand of its master!…”

Section: Introductionmentioning

confidence: 99%

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Group “G” B-Hemolytic Streptococcus a New Important Causative Organism of Localised Intra-Abdominal Abscess

Chopra¹,

Vk²,

Sardana³

et al. 2014

J Clin Case Rep

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Case Report58 years lady, borderline diabetic presented to us in the emergency on oral hypoglycemic/ antihypertensive therapy, with a 6 days history of abdominal pain right side abdomen and right iliac fossa which markedly increased over last 36 hours. She had 2 episodes of chills with high grade fever 102 degrees fahrenheit, with raised counts of up-to 14,500/mm 3 . Her ultrasound examination done a day back showed thickened inflamed bowel wall-appendix involved in the ileocaecal region without any collection, rest of the viscera was normal. On examination we saw a moderately dehydrated lady, fully conscious, anxious, febrile 99 degree F temperature, pulse 90/minute, blood pressure-120/70, respiratory rate of 18/minute, abdominal findings revealed infra-umbilical midline LSCS scar (28 years ago), severe tenderness right iliac fossa, with a rebound tenderness present, PR examination showed fecal matter present. Her labs revealed raised counts 12,400/mm 3 , neurtophils of 86%, amylase/lipase within normal limits, rest of her labs were essentially normal. After urgent Preanaesthetic checkup/Full informed high risk consent she was taken up for surgery. Diagnostic laparoscopy revealed lot of adhesions with purulent exudate in the right paracolic gutter, with tight confines so it was decided to convert to open laparotomy by entering the abdomen via the old scar in the midline and entering the peritoneal cavity onto right side of the adhesions. The omentum was densely adherent to anterior abdominal wall in the midline effectively dividing the lower abdomen into right and left halves. The ileocaecal region was identified and the mesentry of the terminal ileum, caecum was grossly edematous and thickened, almost about 10 to 12 cm thickness and on lifting the cecum in the retro-caecal area a very small collection was drained only about 10 ml thick very foul smelling yellow pus which was removed in a syringe and sent for culture/sensitivity, appendix was not seen, probably liquefied only the base was seen identified by the converging taenia on the caecum, which was ligated, its thickened inflamed mesentery was removed and sent for histopathological examination, the rest of the intestine appeared viable but friable so too much handling was also avoided, the uterus/appendages and rest of viscera on examination appeared normal, peritoneal toileting was done with copious warm saline and a thick bore tube drain 32 french was left in the pelvis, the left half of the abdomen did not appear to be contaminated so it was now decided to close the abdomen with interrupted prolene 1-0 figure of "8" sutures, in layers. She had been started on cefoperazone+sulbactam/ metronidazole/amikacin injections, and shifted to the icu. On 1 st postoperative day her counts rose to 14,700/mm, neutrophils of 89%, Ultrasound examination abdomen-did not reveal any collection/repeat chest X-ray was normal. On the 2 nd postoperative day she showed a febrile peak of 99 degree F, so it was decided by the team to upgrade her antibiotics to inj meropenem+inj ...

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Clinical presentations and epidemiology of β-haemolytic streptococcal bacteraemia: a population-based study

Cited by 71 publications

References 21 publications

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp.equisimilis

Multilocus Sequence Analysis of Streptococcus canis Confirms the Zoonotic Origin of Human Infections and Reveals Genetic Exchange with Streptococcus dysgalactiae subsp.equisimilis

Population-Based Epidemiology and Microbiology of Community-Onset Bloodstream Infections

Group “G” B-Hemolytic Streptococcus a New Important Causative Organism of Localised Intra-Abdominal Abscess

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