Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand

Rojanaporn, Duangnate; Attaseth, Taweevat; Dieosuthichat, Wimwipa; Leelawongs, Kitikul; Pakakasama, Samart; Anurathapan, Usanarat; Chanthanaphak, Ekachat; Ayudhaya, Sirintara Singhara Na; Aroonroch, Rangsima; Hongeng, Suradej

doi:10.1155/2020/4231841

Cited by 8 publications

(10 citation statements)

References 54 publications

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“…This resulted in eyeball salvation rate of 13% and vision salvation rate of 12% in our study population. In our study, we found significantly lower rates of eyeball salvation and vision salvation as compared with the study from other developing countries like Thailand, which found globe salvation rates of 52% 18 and globe salvation rate of 100% in studies from developed countries. 9,19,20 Similar to our study, rate of globe salvation reported in the study from PGIMER, Chandigarh, India, was only 17%.…”

Section: Discussioncontrasting

confidence: 66%

Clinicoepidemiological Profile and Treatment Outcomes in Children with Retinoblastoma: Experience from a Cancer Care Center in Northeast India

Hazarika

Kumar

Saikia

et al. 2022

South Asian J Cancer

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Background Retinoblastoma (RB) is the most common primary intraocular malignancy in children. We sought to provide a comprehensive assessment of epidemiological profile and treatment outcomes of children with RB. Methods In this retrospective study, we analyzed 189 children diagnosed with RB at our center between 2004 and 2017. Survival was analyzed with the Kaplan–Meier method and log-rank test. Results Median age at presentation was 14 months with male: female ratio 1.2:1. Mean duration between onset of symptoms and presentation was 49 days (standard deviation ± 79). Most common presenting symptom was white pupillary reflex in 60% of children. Family history of RB and other cancers was found in one (0.5%) and seven (4%) children, respectively. Primary mode of diagnosis and staging was ocular ultrasonography (bone scan) in 87% of patients. Computed tomographic scan and magnetic resonance imaging were done in 124 (66%) and 30 (16%) patients, respectively. International staging system grade E disease was found in 144 (76%), extraocular disease in 55 (29%), bilateral disease in 49 (26%), and trilateral disease in 3 (1.5%) children. Out of 189 children with RB, 33 (18%) refused treatment and 156 children received treatment (24 children [15%] abandoned treatment midway and 132 [85%] completed treatment). One hundred children (64%) received systemic therapy as neoadjuvant or adjuvant chemotherapy and 20 (13%) received local therapy. Eyeball and vision salvage rate with chemotherapy were 20 (13%) and 9 (6%), respectively. Cryotherapy was the most common modality of local treatment used in 11 (55%) children. Five-year survival for patients who received treatment was 76% (median survival not reached). In the treatment refusal group, median survival was 9 months. Conclusion In developing countries, RB is mostly detected in advanced stages resulting in poor outcomes. Increased awareness and accessibility to dedicated centers for treating childhood malignancy can lead to early diagnosis, better prognosis, and increased vision salvage.

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Section: Discussioncontrasting

confidence: 66%

Clinicoepidemiological Profile and Treatment Outcomes in Children with Retinoblastoma: Experience from a Cancer Care Center in Northeast India

Hazarika

Kumar

Saikia

et al. 2022

South Asian J Cancer

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“…This self-report questionnaire designed by the authors included the age of the patient's father or mother, place of residence, marital status, education, occupation, sleep status, health status, family income, knowledge of RB (nothing at all, know a little, know), patient's age, sex, time since diagnosis, ocular disease (monoculus or binoculus), times of hospitalizations, disease status (under treatment, under re-examination, cured), tumor stage at diagnosis (including [21] extraocular RB and intraocular RB,classified by the International Classification of RB), treatment types. The variable 'sleep status', 'health status' were rated on a five-point scale ranging from "very good" =1 to "very poor" =5.…”

Section: Demographic Questionnairementioning

confidence: 99%

Hope level and associated factors among parents of retinoblastoma patients during COVID-19 pandemic: a cross-sectional study

et al. 2021

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Background The 2019 coronavirus disease (COVID-19) is a global public health emergency. So far, only a limited number of studies have investigated the impact of the COVID-19 pneumonia pandemic on the mental health of parents having children with cancer. This study investigated the hope, and relevant influencing factors (depression, anxiety, demographic data) among parents whose children had retinoblastoma (RB) during the COVID-19 pandemic. Methods A cross-sectional survey and a convenient sampling survey were conducted on 317 parents of RB children admitted to the Ninth People’s Hospital affiliated with Shanghai Jiao Tong University, School of Medicine, and Qilu Children’s Hospital of Shandong University. The survey tools included Demographic Questionnaire, Herth Hope Index (HHI), The Generalized Anxiety Disorder (GAD-7), and the Patient Health Questionnaires (PHQ)-2. Results The hope level score of the parents of RB patients was (35.36 ± 4.42), which was at the medium level. The highest dimension of hope score was inner positive readiness and expectancy (12.07 ± 1.57), and the lowest dimension was interconnectedness with self and others (11.50 ± 1.64). The incidence rate of depression and anxiety was 29.97% (95/317) and 41.32% (131/317), respectively. Monoculus or binoculus disease, sleep status, health status, and depression /anxiety had statistically significant effects on the parental hope level (p < 0.05). Multiple linear regression analysis revealed that time since diagnosis, education level, treatment type and depression were independent influencing factors (p < 0.05), accounting for 22.60% of the variation in hope level. Conclusion During the COVID-19 pandemic, medical staff should formulate targeted intervention measures according to different characteristics of ocular disease, time since diagnosis, treatment type, parental educational level and emotional state in order to improve the level of parental hope.

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“…The globe salvage rate of 30% in unilateral disease in our centre is in line with other tertiary centres globally which range from 7-40%. [23][24][25] This salvage rate, compares favourably to the 8% salvage rate our centre between 1974 and 2005 [14] and reflects the significant improvement in treatment modalities and outcomes.…”

Section: Discussionmentioning

confidence: 53%

Management and Outcomes of Retinoblastoma Cases Presenting to Children’s Hospital Westmead, Sydney Between 2008 and 2018

Starte¹,

Taher²,

Powys³

et al. 2021

IJOVS

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This retrospective review reports on the management and outcomes of retinoblastoma in children treated at Children's Hospital Westmead (CHW), Sydney. Results were compared to those of a previous retrospective review of RB cases presenting between 1974 and 2005 at the same centre, which was published in this journal. A retrospective review of all cases of retinoblastoma presenting to the Children's Hospital Westmead Medical between 2008 and 2018 was conducted. 67 patients were included in the study with a mean age at presentation of 23.5-months and 9.2-months for unilateral and bilateral disease respectively. All patients in our cohort were offered genetic testing. The rate of germline RB1 mutation in our cohort was 29% for unilateral disease and 86% for bilateral disease. Mean follow-up period was 48 months. Globe salvage rates in patients with bilateral disease was 57%, compared to the previous study which was 47%. The most common treatment-related ocular complication was strabismus. Our cohort had only one patient develop metastatic disease and one patient who presented with trilateral disease, which was a case of delayed presentation and was the only mortality in the study. Morbidity and mortality rates in our cohort are on par with other tertiary centres internationally. There has been a significant improvement in globe salvage rate with our current management protocol. As intra-arterial chemotherapy is implemented into the treatment regime at CHW, these results will provide a benchmark to ensure that the excellent standards of care and outcomes are maintained.

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Clinical Presentations and Outcomes of Retinoblastoma Patients in relation to the Advent of New Multimodal Treatments: A 12-Year Report from Single Tertiary Referral Institute in Thailand

Cited by 8 publications

References 54 publications

Clinicoepidemiological Profile and Treatment Outcomes in Children with Retinoblastoma: Experience from a Cancer Care Center in Northeast India

Clinicoepidemiological Profile and Treatment Outcomes in Children with Retinoblastoma: Experience from a Cancer Care Center in Northeast India

Hope level and associated factors among parents of retinoblastoma patients during COVID-19 pandemic: a cross-sectional study

Management and Outcomes of Retinoblastoma Cases Presenting to Children’s Hospital Westmead, Sydney Between 2008 and 2018

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