Clinical Presentations and Surgical Approach of Acute Intussusception Caused by Peutz–Jeghers Syndrome in Adults

Hong, Wang; Luo, Ting; Liu, Wen-qu; Huang, Yan; Wu, Xiaoting; Wang, Xiu‐Jie

doi:10.1007/s11605-011-1724-2

Cited by 30 publications

(34 citation statements)

References 26 publications

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“…In our study, at the time of admission, seven patients (43.8 %) had diagnosed associated pathologies which could be responsible for the invagination, three (18.8 %) with PJS, and two (12.5 %) HIV positive. Although several reports identify these two pathologies as the underlying cause of AI [14,[21][22][23], others mention this only occurs rarely [24,25]. Given an overall 31.3 % of the studied patients had either PJS or HIV; our results support these two pathologies as a frequent cause of AI.…”

Section: Discussionsupporting

confidence: 71%

Adult intussusception: a single-center 10-year experience

et al. 2013

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SummaryBackground Adult intussusception (AI) is a rare condition, usually with a lead point, and for which surgery is the treatment of choice. Given the risks and possible complications of untreated AI, an accurate preoperative diagnosis is of the utmost importance. Although AI remains difficult to diagnose, computerized tomography (CT) is presently considered the best diagnostic tool.Methods Sixteen patients of 20 years and older with intraoperative diagnosis of intussusception, who underwent surgery between January 2000 and December 2009, were reviewed retrospectively. Patients were assessed concerning clinical presentation, imagiological findings, surgical treatment, and postoperative histological evaluation.Results Most patients (93.8 %) were admitted via emergency room (ER) due to abdominal pain. Fourteen (87.5 %) AI cases showed an underlying organic cause, e.g., masses or tumors. The most frequent comorbidities were Peutz-Jeghers syndrome (PJS; 18.8 %) and HIV (12.5 %). Eight (50.0 %) intussusceptions were ileocolic and six (37.5 %) were in the small bowel. Total 43.8 % of lesions were malignant. Preoperative diagnosis of intussusception was possible in 50.0 % of cases by ultrasonography (US) and in 81.8 % by CT. US showed no predictive value concerning intussusception location. Total 27.3 % of CTs correctly identified the location, but only 9 % accurately identified the lead point.Conclusions We propose that all AI cases should be treated with surgical resection without attempting reduction, even when no lead point is detected by imaging studies, and this approach should be based on the oncological criteria. CT can be regarded as the most accurate diagnostic tool for intussusception, although its predictive value concerning location and lead point is still far from ideal.

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Section: Discussionsupporting

confidence: 71%

Adult intussusception: a single-center 10-year experience

et al. 2013

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“…Abdominal CT scan provided the diagnosis of intussusception and identified the nature of the underlying pathology with a sensitivity rate of 100%. This agrees with Hong et al [24] who found that the spot diameter was between 2 and 5 mm. All the patients presented with an acute abdomen.…”

Section: Discussionsupporting

confidence: 93%

“…No postoperative complications were reported. These results are consistent with Hong et al [24] who studied 11 PJS patients with intussusception. All of them had a laparotomy with successful manual reduction of the intussusception.…”

Section: Discussionsupporting

confidence: 92%

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Adult Intussusception in Patients with Peutz-Jeghers Syndrome: Case Series and Review of Literature

Mlees¹,

El-Bakary²,

El-Gendy³

et al. 2017

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Background: Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by gastrointestinal hamartomatous polyps and mucocutaneous pigmentations in the mouth, facial skin, hands & feet. Small bowel obstruction, intussusception, bleeding, intestinal and extra-intestinal malignancies are the major complications of PJS. The aim of this study is to analyze the clinical characteristics, preoperative diagnosis, and surgical management of PJS associated-intussusception in adults. Patients and Methods: This study included 5 cases with intussusception in PJS patients presented to Surgical

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“…The incidence has been estimated to be between 1 in 8,300 and 1 in 200,000 live births (4). The polyps are located predominantly in the small intestine, and may cause various complications, including abdominal pain, anemia and acute intussusceptions (5). Patients with Peutz-Jeghers syndrome have an increased risk of developing cancer or transformation to malignant polyps in the gastroinstestinal tract and other organs (6).…”

Section: Introductionmentioning

confidence: 99%

Acute intussusception and polyp with malignant transformation in Peutz-Jeghers syndrome: A case report

Jiang

2015

Oncology Letters

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Abstract. Intussusception is one of the most frequent complications of Peutz-Jeghers syndrome, and has been well described in previous studies. More attention has been paid to malignancy, which is another complication of Peutz-Jeghers syndrome and which leads to increased mortality. Few cases of intussusception combined with malignant polyps in Peutz-Jeghers syndrome have been reported to date. In the present study, we report a case of intussusception and malignant polyps occurring in various parts of the small intestine in a 43-year-old male. In addition to repair of the intussusception and partial resection of the small intestine with malignant polyps, we also simultaneously performed polypectomy of as many polyps as possible without resection of the small intestine. Our aim is to make clinicians aware of intussusception and malignant polyps coexisting in Peutz-Jeghers syndrome when performing emergency surgery. Prophylaxis and polypectomy of the entire small bowel is an effective way to reduce the frequency of laparotomies in patients with this disease.

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Clinical Presentations and Surgical Approach of Acute Intussusception Caused by Peutz–Jeghers Syndrome in Adults

Cited by 30 publications

References 26 publications

Adult intussusception: a single-center 10-year experience

Adult intussusception: a single-center 10-year experience

Adult Intussusception in Patients with Peutz-Jeghers Syndrome: Case Series and Review of Literature

Acute intussusception and polyp with malignant transformation in Peutz-Jeghers syndrome: A case report

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