Clinical Profile, Aetiology and Outcome of Afebrile Seizures in Children

Poudel, Prakash; Parakh, Prince; Mehta, Kayur

doi:10.31729/jnma.572

Cited by 9 publications

(11 citation statements)

References 19 publications

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“…). The incidence of neuroimaging abnormality compared too many other studies such as those done by Poudel et al, Rasool et al, Kalnin et al, Mathur et al, Mohammadi et al which showed neuroimaging abnormality to be around 27 % to 35% in new onset afebrile seizures 6,10,[15][16][17]. Of the 65 patients in the present study, 22 had neuroimaging abnormality and 16 had abnormalities on neurological examination.…”

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confidence: 41%

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Evaluation of neuroimaging findings in new onset afebrile seizures in children

Muthuraja

Paramasivam

2018

Int J Contemp Pediatr

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Background: New onset afebrile seizures are very common in children. They are diagnosed by neuroimaging techniques. The aim of the present study was to examine the presenting characteristics and to assess and compare the prevalence of neuroimaging and neurological abnormalities in new onset afebrile seizures in children. Methods: This prospective study was conducted in a tertiary care hospital at Chennai during the period from July 2014 to August 2016. Out of 65 patients included in the study, 58 had an MRI, 5 had a CT scan and 2 patients had a neurosonogram. All the findings were documented in the proforma and evaluated for incidence of neuroimaging abnormality in children. Results: The most common age group to be affected was the adolescent age group followed by the infantile group. The most common presentation noticed was generalized seizures 72% (47/65). Among the primary generalized seizures, GTCS 57% (27/47) was the most common. Of the 65 patients in our study, 22 had Neuroimaging abnormality and 16 had neurological abnormality. The most common abnormalities seen in various neuroimaging studies were ring enhancing lesions 10 (45%). Ring enhancing lesions were more common in the adolescent age group, while structural disorder was more common in the infantile age group. Conclusions: Neuroimaging techniques helped in finding the brain developmental abnormalities among children with afebrile seizures.

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confidence: 41%

“…This might be due to birth asphyxia, neurocysticercosis and nervous system infections and other risk factors. 6,7 The basis of incidence can be evaluated by EEG. It is mostly useful in investigating afebrile epileptic seizures and its risk of recurrence.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of neuroimaging findings in new onset afebrile seizures in children

Muthuraja

Paramasivam

2018

Int J Contemp Pediatr

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“…Structural etiologies were the most common, accounting to 66.11%, followed by metabolic in 12.39%, unknown etiology in 8.26%, infection sequelae in 6.61%, hot water epilepsy in 4.95%, and immune etiology in 0.82%. Most common structural cause of seizures was secondary to hypoxic-ischemic insult/perinatal insult (38%), which was similar to a study carried out by Poudel et al ,[15] who found that birth asphyxia (12%) was the most common cause of afebrile seizure followed by neurocysticercos (8.8%), sequel of CNS infection (6.5%), and cerebral malformation (7.1%). In this study, metabolic causes were the second most common with Leigh syndrome being the frequent cause [Table 2].…”

Section: Discussionsupporting

confidence: 87%

Etiological profile of afebrile seizures in infants in a tertiary care center from southern India

et al. 2019

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A bstract Introduction: Seizure is the most common neurological illness in pediatric population and its risk is highest in the first year of life. Studies regarding etiology of afebrile seizures worldwide and in India are limited; hence, the current study was undertaken. Objective: The objective of this work was to study the etiology of afebrile seizures in infants aged 1 month to 1 year. Materials and Methods: A retrospective study of afebrile infantile seizure was conducted at pediatric neurology outpatient department between January 2015 and September 2017. All children with first episode of afebrile seizures were included. Biochemical and hematological investigations, imaging, and electroencephalogram were performed whenever necessary. Simple descriptive statistics were used to analyze the data in the form of frequencies with percentages and median as applicable. Results: One hundred twenty-one children with a mean age of 8.1 months were analyzed. Of these children, 58% were males. Positive family history was found in 1.65% children, developmental delay in 70%, and dysmorphism in 8%. Presenting seizure type were generalized (74%), focal (21%), and unknown (6%) onset. Etiology was deducible in 92% cases. Structural etiology was the most common (66%), followed by metabolic (12%), infections (7%), and others (6%). In structural pathology, common causes were perinatal insult (38%) and cerebral malformations (18%). Imaging was done in 98 cases and yield was 83% (85 cases). Conclusion: Etiology was deducible in 92% of children. Seizures due to structural etiology, secondary to perinatal insult followed by metabolic and infections, are important causes. Imaging aids are important in etiological diagnosis. Etiological evaluation should be considered in children following first episode of afebrile seizures, especially in developing countries like India.

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“…12,13 The rates of epileptiform discharges varied from 44 to 80% in children who were admitted with seizures in reported studies. [14][15][16] In our study, EEG was abnormal in 24% (33) patients. The seizure recurrence rate was statistically higher in patients with abnormal EEG and cranial MRI findings.…”

Section: Discussionsupporting

confidence: 49%

Clinical profile and long-term outcome of the first seizures in children

2021

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Background. Seizures are one of the most common causes of pediatric admissions to hospitals in children. This study aims to identify the clinical profile and outcome of first seizures in children. Methods.Children who presented to the pediatric neurology outpatient clinic and pediatric emergency service with a first-time seizure and aged one month through 18 years old were enrolled to the study. At the time of the study, enrolled children were categorized into three study groups according to seizure characteristics: febrile seizure, nonfebrile-provoked seizure and, unprovoked seizure.Results. The study group consisted of 138 children. Of the 138 patients, 60 (43%) had febrile first seizures, 23 (17%) had nonfebrile-provoked first seizures, and 55 (40%) had unprovoked first seizures. The patients did not experience the recurrence of a seizure by the treatment of underlying cause at the eighteenth month and the eighth year follow-up in the nonfebrile-provoked seizure group. Among the children admitted for unprovoked first seizures, 33 (60%) patients had seizure recurrence during 18 month follow-up and 36 (82%) patients had seizure recurrence during eight year follow-up. Seizure recurrence rate was statistically higher in patients with abnormal EEG and cranial MRI findings in the unprovoked seizure group (p <.05). Conclusions.The patients with provoked first seizure did not develop epilepsy during eight year follow-up. However, 36 patients with unprovoked seizures were diagnosed with epilepsy during eight year follow-up. It is essential to determine the causes of the seizures and treat the condition.

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Clinical Profile, Aetiology and Outcome of Afebrile Seizures in Children

Cited by 9 publications

References 19 publications

Evaluation of neuroimaging findings in new onset afebrile seizures in children

Evaluation of neuroimaging findings in new onset afebrile seizures in children

Etiological profile of afebrile seizures in infants in a tertiary care center from southern India

Clinical profile and long-term outcome of the first seizures in children

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