Clinical profile and drug resistance patterns of typhoid fever in children: A prospective hospital-based study

Kamaal, Chand Miyan; Kumar, Sushil; Shakya, Pragya; Saini, Virendra Singh

doi:10.21276/apjhs.2018.5.2.39

Cited by 1 publication

(12 citation statements)

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“…We found hepatomegaly in 34% of patients. The current study finding was similar to earlier studies [ 52 , 54 , 56 ]. Laishram et al [ 45 ] and Singh et al [ 47 ] found hepatomegaly in many patients, which is 77.5% and 79.7%, respectively.…”

Section: Discussionsupporting

confidence: 93%

“…In our study, vomiting and abdominal pain were present in 25.5% and 21.1% of patients, respectively. In other studies, vomiting was found in a similar percentage of patients [ 45 , 54 ]. The number was much higher (71.4%) in the study conducted by Rabasa Al et al [ 50 ], whereas it was found in a minimal number of patients (9%) in the study conducted by Islam et al [ 43 ].…”

Section: Discussionsupporting

confidence: 67%

“…Our study's findings on abdominal pain were similar to other studies [ 44 , 46 , 49 ]. Still, the number is much higher in other studies [ 43 , 45 , 47 , 52 , 54 ]. We found hepatomegaly in 34% of patients.…”

Section: Discussionmentioning

confidence: 62%

“…This finding of coated tongue in multiple studies was slightly higher [ 43 , 46 , 49 , 52 , 56 ]. Nonetheless, the coated tongue was much higher (81.63%) in another study [ 45 ] but was less common (14.9%) in one more research [ 54 ].…”

Section: Discussionmentioning

confidence: 90%

“…In our study, most patients were less than five years, which is consistent with another study [ 44 ]. Other studies found that most patients were aged 5-10 years [ 1 , 45 - 47 , 49 - 51 , 54 - 56 ]. Other studies reported that EF patients were common at 10 years or older [ 53 , 57 ].…”

Section: Discussionmentioning

confidence: 99%

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Clinical and Laboratory Features of Enteric Fever in Children and Antibiotic Sensitivity Pattern in a Tertiary Care Hospital of a Low- and Middle-Income Country

Nusrat¹,

Islam²,

Paul³

et al. 2022

Cureus

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Background: Globally, enteric fever (EF) significantly gives rise to an appalling death toll. It is an endemic illness in Bangladesh and South Asia. The condition manifests in a wide range of clinical features in children. Nowadays, antibiotic resistance is an international stumbling block that hampers the appropriate treatment and outcome of EF. Objective: The study evaluated the clinical and laboratory characteristics and antibiotic sensitivity pattern of Salmonella enterica in children. Methods: This prospective research was conducted at Delta Medical College and Hospital, Dhaka, Bangladesh, from January 2017 to December 2019. A total of 200 pediatric cases of EF were included in this study who were either culture positive or had significantly raised Widal test titer for Salmonella with suggestive clinical features. Results: All the patients had a fever, and most had coated tongue, vomiting, abdominal pain, organomegaly, and diarrhea. Among the selected 200 cases of EF, 43.5% were Salmonella typhi culture-positive. A high erythrocyte sedimentation rate (ESR) was observed in a substantial number (53%) of patients. Ceftriaxone was the most sensitive (100%) antibiotic through laboratory analysis, followed by cefotaxime (95.1%). Among the oral antibiotics used, cefixime (92.8%) was the most sensitive. Conclusion: EF in children can present with varied clinical manifestations. Selective antibiotic treatment according to sensitivity patterns is crucial for effective illness management and will reduce morbidity and mortality in the pediatric population.

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