Clinical profile and outcome in Bacillus endophthalmitis

Das, Taraprasad; Choudhury, Kushal; Sharma, Savitri; Jalali, Subhadra; Nuthethi, Rishita

doi:10.1016/s0161-6420(01)00762-x

Cited by 59 publications

(26 citation statements)

References 28 publications

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“…are a major cause of rapidly blinding cases of post-traumatic and endogenous endophthalmitis. The majority of patients with Bacillus endophthalmitis lost significant visual function or the eye itself in less than 2 to 3 days (Das, et al, 2001(Das, et al, ,2005David, et al, 1994;Ho, et al, 1982;O'Day, et al, 1981). B. cereus causes the vast majority of Bacillus endophthalmitis cases.…”

Section: Bacillusmentioning

confidence: 99%

Bacterial endophthalmitis: Therapeutic challenges and host–pathogen interactions

Callegan

Gilmore

Gregory

et al. 2007

Progress in Retinal and Eye Research

156

153

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Endophthalmitis is an infection of the posterior segment of the eye that frequently results in loss of vision. This devastating result occurs despite prompt and often aggressive therapeutic and surgical intervention. Over the past decade, research has centered on determining the bacterial and host factors involved in this potentially blinding disease. The initial focus on the bacterial factors responsible for intraocular virulence has recently expanded into analysis the inflammatory response to infection, including the molecular and cellular interactions between the pathogen and host. This review discusses the epidemiology and therapeutic challenges posed by endophthalmitis, as well as recent findings from the analysis of interactions between the host and pathogen. Based on these findings, a model for the pathogenesis of endophthalmitis is presented. A more comprehensive understanding of the molecular and cellular interactions taking place between pathogen and host during endophthalmitis will expose possible therapeutic targets designed to arrest the infection and prevent vision loss.

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Section: Bacillusmentioning

confidence: 99%

Bacterial endophthalmitis: Therapeutic challenges and host–pathogen interactions

Callegan

Gilmore

Gregory

et al. 2007

Progress in Retinal and Eye Research

156

153

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“…In approximately half of cases of severe B. cereus endophthalmitis, the eye must be removed. 3,4 Ocular architecture remained intact following 6 h treatment with either antibiotic, indicating that treatment delays of 6 h may not salvage vision, but may preserve the globe. Summary: During post-traumatic Bacillus endophthalmitis, spores likely enter the eye and germinate into viable bacteria that produce toxins and incite an explosive inflammatory response that is usually refractory to treatment.…”

Section: Progress To Datementioning

confidence: 99%

Improved Therapeutic Regimens for Treatment of Post-Traumatic Ocular Infections

Callegan¹

2009

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“…Bacillus species have been reported to occur after trauma, but also after glaucoma and cataract surgery, involving contaminated irrigating solutions or OVDs. [7][8][9][10][11][12] Culture of the OVD used to load the lens in the first case described here was not performed. In any event, with intra-and postoperative antibiotic therapy, the postoperative course of the case was uneventful, and only corneal oedema was observed during the first postoperative week.…”

Section: Marketing Personal Communication November 2003)mentioning

confidence: 99%

Intraoperative explantation of two single-piece hydrophobic acrylic intraocular lenses due to surface deposits

Hickman

Werner

Mamalis

et al. 2005

Eye

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Purpose To report clinical, pathological, and laboratory analyses of two cases of singlepiece hydrophobic acrylic intraocular lenses (IOLs), which presented with significant surface deposits during implantation. Methods The lenses were implanted with the manufacturer's recommended injector (loaded with Viscoat s and Healon GV s , respectively). Immediately after injection into the anterior chamber, areas on the lenses' surfaces were covered by deposits, which could not be entirely removed by irrigation/aspiration. The lenses were explanted and replaced with lenses of the same design. They underwent gross analyses, light microscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy for analysis of the elemental composition of the deposits. Liquid chromatography/mass spectroscopy was also performed to identify the presence of proteins. Results The deposits on the first lens had a granular appearance, forming a homogeneous layer mostly on the posterior lens surface. Larger crystal-like deposits were present mostly on the anterior surface of the second lens. Elemental analyses of the deposits in both cases revealed the presence of peaks of sodium, chloride, phosphate, and potassium, in addition to the peaks of carbon and oxygen (normal constituents of the lens material). Only protein components normally found in the anterior chamber during surgery, such as haemoglobin and albumin, were identified. Conclusions The results obtained suggest that the deposits in both cases may have resulted from crystallization of the ophthalmic viscosurgical device normally used during the loading of the IOLs into the cartridges.

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Clinical profile and outcome in Bacillus endophthalmitis

Cited by 59 publications

References 28 publications

Bacterial endophthalmitis: Therapeutic challenges and host–pathogen interactions

Bacterial endophthalmitis: Therapeutic challenges and host–pathogen interactions

Improved Therapeutic Regimens for Treatment of Post-Traumatic Ocular Infections

Intraoperative explantation of two single-piece hydrophobic acrylic intraocular lenses due to surface deposits

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