Clinical Profile and Outcome of Neonates With Hypernatremic Dehydration - A Tertiary Care Hospital Based Study

Abstract

Objectives: Materials And Methods: Clinical prole and outcome of neonates with hypernatremic dehydration. Cross sectional study conducted in a tertiary care centre in central India, includes sick neonates aged less than 28 days admitted in hospital for a period from April 2022 to March 2023, who found to have hypernatremic dehydration on admission with serum soidum >150 mEq/L. Clinical and demographic information in relation to mother and baby were recorded. Out of total 2076 neonates admitted during t Results: he study period, 25 babies were diagnosed as a hypernatremic dehydration, showing an institute prevalence of 1.2%. Median age of presentation was 9 days, with female to male ratio 1.03. 92% of the babies were exclusively breast fed.76 % were born via normal delivery. Maximum presented with not accepting feed (96%), along with fever (64%), decreased urine output (52%), convulsions (28%). Admitted babies had a mean serum sodium level of 173.9 mEq/L, with as high as 200 mEq/L. 9 babies (36%) presented with shock,19 (76%) presented with evidence of kidney injury. Statistically signicant correlation was found between percentage of weight loss to mortality and serum sodium levels to mortality. Hypernatremic dehydration is a common Conclusion: medical emergency encountered in neonatal ICU and can be caused by poor feeding. Early diagnosis and appropriate treatment are crucial for survival and better prognosis.

Detection of multidrug resistant organisms of concern includingS. maltophiliaandB. cepaciaat a referral hospital in Kenya

“…Trauma patient samples yielded the largest number of bacterial isolates (33.1%) since most of them had undergone orthopaedic surgery and were in the surgical ward. This finding is similar to a previous study that recorded high rates of bacterial infection in orthopaedic patients (35).…”

“…The effective drugs against E. coli were amikacin and carbapenems. This is in consistency with a similar study carried out elsewhere (35). Acinetobacter baumannii, Burkhholderia cepacia and S. maltophilia isolates were highly resistant to all groups of drugs and this is in consistency with findings from other studies (47)(48) (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.…”