Clinical Profile and Outcome of Pediatric Sarcoidosis

Gunathilaka, P. K. G.; Mukherjee, Aparna; Jat, Kana Ram; Lodha, Rakesh; Kabra, S. K.

doi:10.1007/s13312-019-1464-z

Cited by 8 publications

(1 citation statement)

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“…Hepatosplenic involvement in sarcoidosis can occur in up to 43% of patients in the course of the disease. 3,5,16 However, clinical manifestations of this involvement are uncommon, and massive splenomegaly as an initial manifestation is rare. 17,18,19 In hepatic sarcoidosis, liver transaminases levels are usually normal or moderately increased (2-3 times), 50-70% have increased GGT and/or ALP and, rarely, increased bilirubin.…”

Section: Discussionmentioning

confidence: 99%

Prolonged fever, pancytopenia, and splenomegaly - is it sarcoidosis?

et al. 2023

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Childhood Sarcoidosis is a chronic multisystem pinflammatory disease of unknown etiology. We report a case of a 9-year-old female who presented with nasal bleeding. She started with fever that persisted for 24 days associated with progressive splenomegaly, pancytopenia, and generalized lymphadenopathy. An extensive investigation was performed excluding infectious, neoplastic, autoimmune and immunodeficiency causes. Histological examination of a lymph node revealed multiple non-caseous granulomas, which together with the elevation of ACE and multiorgan involvement, suggested the diagnosis of sarcoidosis. She started oral prednisolone and after 4-month of follow-up there was a significant clinical and analytic improvement. This case represents a challenging diagnosis of an uncommon pediatric disease that should be considered in the differential diagnosis of a multisystemic disease with constitutional symptoms even in the absence of pulmonary involvement.

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