Clinical Profile and Outcome of Dengue Infection in and Around Kurnool

Abstract

The relationship of India with dengue has been long and intense. The first recorded epidemic of clinically dengue like illness occurred at Madras in 1780, and the dengue virus was isolated for the first time almost simultaneously in Japan and Calcutta in 1943-1944. After the first virologically proved epidemic of dengue fever along the East Coast of India in 1963-1964, it spread to all over the country. The first full-blown epidemic of the severe form of the illness, the dengue hemorrhagic fever/ dengue shock syndrome occurred in North India in 1996. 2 Surveys conducted by the health ministry indicate that the dengue prevalence rate was 3.4 percent in 2006, rising to 5.25 percent in 2007, and by 2009 to 9.1 percent. Hospital based Prospective Clinical Study: Study included 1004 children clinically suspected of being infected with dengue virus in the epidemic of July-December 2011 occurred during the study period. Thrombocytopenia was seen in 663(66%), NS1 Ag 364(36%), IgM Ab 316(31%), and IgG Ab were 201(20%). Among these survivals were 265(92.98%) and deaths 20(7.02%). Comparatively thrombocytopenia when associated with negative serological tests survivals were 374(98.42%) and deaths 6(1.58%).