Clinical Profile and Outcome of Haemodialysis in Patients With COVID-19 – A Single Centre Experience

Vardhan, Harsh; Kumar, Amit; Shyama, Shyama; Chaudhary, Neha; Pandey, Sanjay Kumar; Deependra, K; Kumar, Deepak; Kumar, Sanyal

doi:10.7759/cureus.17170

Cited by 3 publications

(4 citation statements)

References 28 publications

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“…We also noted lower serum albumin levels among patients who died (p = 0.04) which is similar to the observation made by Vardhan et al from eastern India. 27 This consolidates our finding that patients with BMI ≥ 23 (overweight Indian dialysis patients) or those having adequate nutrition do better than those who are having protein-energy wasting.…”

Section: P a T I E N T S W I T H E S R D D U E T O T H E I R I M M U ...supporting

confidence: 76%

COVID-19: Clinical Course and Outcome of hospitalized Hemodialysis Patients: Single-center Experience

Shah¹,

Mital²,

Patel³

et al. 2023

JAPI

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Background: There is a paucity of data regarding the consequences of coronavirus disease 2019 (COVID-19) infection in patients with maintenance hemodialysis (MHD). Our objective was to identify the clinical manifestations and prognostic factors and to assess the impact of treatment schemes on the outcome. Materials and methods: Here we present retrospectively collected data from medical records of patients on MHD hospitalized with COVID-19 infection from 1st June to 30th November 2020. Result: Around 69 patients were admitted with a median age of 51 years. About 81% had hypertension, 41% had diabetes, and 24% had body mass index (BMI) ≥ 23 kg/m2 . Of all who died, 73.33% had dialysis vintage of <12 months (p = 0.06). Common presenting symptoms were fatigue (67%), fever (58%), cough (42%), and dyspnea (35%). Milder, severe, and critical disease was found in 35, 45, and 20% of patients, respectively. About 54 patients were living 4 weeks after discharge. Around 15 patients died, that includes all who received invasive ventilatory support. Nonsurvivors were older and had lower oxygen saturation on admission, lower hemoglobin (Hb), and worst lactate dehydrogenase (LDH), interleukin (IL)—6, and D-dimer values than survivors, which were statistically significant. Use of remdesivir and anticoagulant improves chances of survival (p-value 0.035 and 0.034, respectively) Conclusion: About one-third of patients had mild disease. Those with critical disease displayed high mortality. Older age, male gender, short dialysis vintage, lower oxygen saturation on admission, anemia, leucocytosis, higher inflammatory markers [except C-reactive protein (CRP)], bilateral lung opacity, and requirement of the mechanical ventilator are poor prognostic factors. CRP, ferritin, and lymphopenia are not good prognostic markers unlike in the general population. These findings need to be verified in larger cohorts.

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Section: P a T I E N T S W I T H E S R D D U E T O T H E I R I M M U ...supporting

confidence: 76%

COVID-19: Clinical Course and Outcome of hospitalized Hemodialysis Patients: Single-center Experience

Shah¹,

Mital²,

Patel³

et al. 2023

JAPI

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“…This observation is parallel to other studies. 10,[28][29][30] Furthermore, an undersized proportion (13.3%) of patients presented with any comorbidity in our study, compared with 21.7 % and 21.1% of patients with the coexisting condition reported during the first and second wave respectively. 27 Although Moderate/Severe Covid infections were higher in patients with one or more comorbidities.…”

Section: Comparison Between the First Second And Third Waves Of The C...mentioning

confidence: 68%

“…Backing our study findings, Vardhan H mentioned in their study paper that the SARS-CoV-2 infection causes more severe illness in patients with comorbid diseases such as diabetes and hypertension. 30 Sharing similar findings, Zhang et al studied 633 COVID-19 patients in China, of whom 247 patients had at least one comorbidity and were more likely to exhibit a more severe form of COVID-19 illness. 31 Similarly, another study conducted in Spain had more severe illnesses among patients with comorbidities.…”

Section: Comparison Between the First Second And Third Waves Of The C...mentioning

confidence: 77%

Clinico-epidemiological and vaccination profile of patients attending flu clinic of a tertiary health care institution in Eastern India during the third wave of COVID-19 pandemic

Singh¹,

Chaudhary²,

Naik³

et al. 2022

Eur J Clin Exp Med

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Introduction and aim. With the third wave of COVID-19 hitting the country, there is an urgent need to systematically document the clinical-epidemiological and vaccination details of the patients to formulate evidence-based decisions. So, this study was planned to describe the profile of patients attending the flu clinic of a tertiary care hospital in eastern India. Material and methods. This hospital-based cross-sectional study was done for 6 weeks (Jan-Feb 2022) among 623 patients using a pre-tested, structured questionnaire related to COVID-19. An unadjusted odds ratio was calculated and statistical significance was attributed to a p-value <0.05. Results. Out of 623 patients, almost 90% of the patients were vaccinated against COVID-19 with at least one dose of any vaccine. Cough (57.8%) was the most common complaint. Patients aged > 60 years and those having one or more than one comorbidity suffered from moderate-severe COVID-19 infection when compared to their counterparts (p<0.001). Also, 2.1% of fully vaccinated, 3.8% of one dose vaccinated and 10.9% of unvaccinated patients suffered from moderate-severe COVID-19. Conclusion. During the third wave of the COVID-19 pandemic, a smaller number of elderlies compared to the previous two waves were affected indicating age shifting. The severity of COVID-19 was less among vaccinated individuals compared to unvaccinated highlighting the importance of COVID-19 vaccination.

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“…Increasing age was associated with death, which is similar to the results of previous studies. [11][12][13]15,18,22 Nonetheless, older age is a known factor affecting the survival of COVID-19 patients, not just the ESRD patients, given that older individuals tend to have more comorbidities and poorer immune status. 12 The present study also shows that, sex is a risk factor for mortality which was not observed in previous studies among ESRD patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Mortality among End-Stage Renal Disease Patients with COVID-19 Admitted in a Philippine Tertiary Government Hospital: A Retrospective Cohort Study

2024

Acta Med Philipp

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Background andObjective. Several studies have examined the predictors of mortality among COVID-19-infected patients; however, to date, few published studies focused on end-stage renal disease patients. The present study, therefore, aims to determine the predictors of in-hospital mortality among end-stage renal disease patients with COVID-19 admitted to a Philippine tertiary hospital.Methods. The researcher utilized a retrospective cohort design. A total of 449 adult end-stage renal disease patients on renal replacement therapy diagnosed with moderate-to-severe COVID-19 and were admitted at the National Kidney and Transplant Institute from June 2020 to 2021 were included. Logistic regression analysis was used to determine the factors associated with in-hospital mortality. Results.In-hospital mortality among end-stage renal disease patients with COVID-19 was 31.18% (95% CI: 26.92-35.69%). Older age (OR=1.03), male sex (OR=0.56), diabetes mellitus (OR=1.80), coronary artery disease (OR=1.71), encephalopathy (OR=7.58), and intubation (OR=30.78) were associated with in-hospital mortality. Conclusion.Patients with ESRD and COVID-19 showed a high in-hospital mortality rate. Older age, diabetes mellitus, coronary artery disease, encephalopathy, and intubation increased the odds of mortality. Meanwhile, males had lower odds of mortality than females.

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Clinical Profile and Outcome of Haemodialysis in Patients With COVID-19 – A Single Centre Experience

Cited by 3 publications

References 28 publications

COVID-19: Clinical Course and Outcome of hospitalized Hemodialysis Patients: Single-center Experience

COVID-19: Clinical Course and Outcome of hospitalized Hemodialysis Patients: Single-center Experience

Clinico-epidemiological and vaccination profile of patients attending flu clinic of a tertiary health care institution in Eastern India during the third wave of COVID-19 pandemic

Predictors of Mortality among End-Stage Renal Disease Patients with COVID-19 Admitted in a Philippine Tertiary Government Hospital: A Retrospective Cohort Study

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