Clinical Profile and Outcome of Asphyxiated Newborn in a Medical College Teaching Hospital

Panthee, Kiran; Sharma, Kiran; Kalakheti, Balkrishna; Thapa, Kul

doi:10.22502/jlmc.v4i1.78

Cited by 7 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13 Panthee et al observed 24.4%cases developed HIE Grade I, 23.17% developed HIE Grade II and the remaining 9.75% cases developed HIE Grade III. 14 In the present study, Grade I HIE was seen in 68.0% neonates, Grade II was seen in 22.70% and 9.30% cases had Grade III HIE. Although distribution of HIE Grades is variable in different studies, the percentage of neonates with HIE Grade III is less in all studies which shows very less proportion of newborns suffer severe HIE.…”

Section: Discussionsupporting

confidence: 52%

Acute Renal Failure in Newborns with Birth Asphyxia

Kanodia

Sah

et al. 2022

J. Nepalgunj Med. College

View full text Add to dashboard Cite

Introduction: Perinatal asphyxia is one of the common causes of neonatal morbidity and mortality. It can affect almost all the body organs and most frequently affected organs are kidneys. Acute Renal Failure is the commonest renal complication, manifested by changes in urine output and blood chemistries. Aims: To evaluate the renal function in asphyxiated newborns. Methods: This cross-sectional study was conducted, from August 2021 to February 2022, on 95 term neonates admitted in Neonatal Intensive Care Unit of Nepalgunj Medical College, Kohalpur for birth asphyxia as per World Health Organization definition. All neonates with Hypoxic Ischemic Encephalopathy were staged by Sarnat and Sarnat staging. After 48 hours of life, blood sample was sent for investigations. Urine output was monitored and neonates were managed according to the hospital protocol. Results: Male to female ratio was M:F 1.90:1. Percentage of acute renal failure was higher in babies with higher Hypoxic Ischemic Encephalopathy grades. It was seen in 12% in Grade I, 82% in Grade II and 100% in Grade III. Renal failure had significant association with Hypoxic Ischemic Encephalopathy staging(p<0.05).The means of serum creatinine significantly increased with the increase in Hypoxic Ischemic Encephalopathy grades (p<0.05). Mean serum creatinine among Grade I, Grade II and Grade III newborns were 0.9±0.44, 2.2±.93and 2.9±0.38 mg/dl respectively. Mean urinary output significantly decreased as the grades of Hypoxic Ischemic Encephalopathy increased (p<0.05) with mean urine output 1.5±0.38, 1.3±0.53and 1.1±0.39 ml/kg/hour respectively in Grade I, Grade II and Grade III. Conclusion: Neonates with higher grades of Hypoxic Ischemic Encephalopathy had higher values of serum creatinine. Urine output decreased as the grading of asphyxia increased

show abstract

Section: Discussionsupporting

confidence: 52%

Acute Renal Failure in Newborns with Birth Asphyxia

Kanodia

Sah

et al. 2022

J. Nepalgunj Med. College

View full text Add to dashboard Cite

show abstract

“… 10 , 11 In our study, the prevalence of perinatal asphyxia is 3.66%. This finding is quite low as compared to other studies done in Nepal as in Nepal Medical College 15.9% by Shrestha S et al, 9 26.9% at Kathmandu University School of Medical Sciences, Dhulikhel by Dangol S et al, 12 17.3% at College of Medical Sciences, Bharatpur by Gupta SK et al 13 and 19.3% at Lumbini Medical College Teaching Hospital by Panthee K et al 14 The possible factors for such a low prevalence of perinatal asphyxia in KMCTH could be due to better intrapartum fetal monitoring (using Doppler Fetoscope, availability of USG in labor room, proper use of partographs during labor period) and immediate interventions like emergency cesarean section and instrumental delivery which have helped in reducing intrauterine asphyxia. Availability of level III neonatal care like bubble CPAP, mechanical ventilator support and surfactant replacement therapy at NICU and floor night duty of second on call Obstetricians and Pediatricians with Post Graduate resident doctors involved in every high risk deliveries might have helped in reducing perinatal asphyxia and immediate better neonatal resuscitation care could have reduced its complications of perinatal asphyxia.…”

Section: Discussionmentioning

confidence: 55%

Prevalence of Perinatal Asphyxia in Neonates at a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Manandhar¹,

Basnet²

2019

J Nepal Med Assoc

View full text Add to dashboard Cite

Introduction: Perinatal asphyxia is one of the major causes of perinatal and early neonatal mortality in developing countries. The main objective of this study was to observe the prevalence of perinatal asphyxia in babies born at Kathmandu Medical College Teaching Hospital. Methods: This was a descriptive cross-sectional study conducted at Kathmandu Medical College Teaching Hospital over six month period (January to June 2019). All preterm, term and post term babies delivered at Kathmandu Medical College Teaching Hospital were included. Ethical clearance was received from Institutional Review Committee of Kathmandu Medical College (Ref.:2812201808). Convenient sampling method was applied. Data analysis was done in Statistical Package for Social Sciences (SPSS 18), point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: A total of 1284 babies delivered over six months period were enrolled in this study and 47 (3.66 %) babies were asphyxiated, at 95% Confidence Interval (2.64%-4.68%). The mean birth weight of asphyxiated babies was 2759.75±65 grams and gestational age was 37.57±2 weeks. Among asphyxiated babies, 15 (32%) babies were normal, 15 (32%) babies were in Hypoxic Ischemic Encephalopathy stage I, 14 (30%) were in stage II and 3 (6%) were in stage III. Twenty Three (49%) asphyxiated babies had antenatal risk factors and all 47 babies had intrapartum risk factors leading to asphyxia. Conclusions: Prevalence of perinatal asphyxia was lower compared to that of other similar tertiary care hospitals. Perinatal asphyxia remains a major cause of neonatal morbidity and mortality.

show abstract

“…There is a marginally higher chance of surviving and recovering from asphyxia in stages I HIE than the counterparts. This conclusion was supported by additional findings [21][22][23][24][25]. The scientific explanation for this finding could be, primarily, in fact, asphyxia is followed by the renal system and the central nervous system as the most severely affected systems.…”

Section: Discussionmentioning

confidence: 53%

Time to recovery of asphyxiated neonates and it’s predictors among newborns admitted to neonatal intensive care unit at Debre Berhan Comprehensive Specialized Hospital, Ethiopia

Yehouala,

Tesfahun,

Dejene

et al. 2024

Preprint

View full text Add to dashboard Cite

BackgroundEven though there have been inquiries into the survival rates of asphyxiated neonates in Africa, there is scarce data concerning the recovery duration for asphyxiated newborns in developing nations and the factors affecting this process. Consequently, the objective of this study is to ascertain the time it takes for asphyxiated neonates to recover and identify its predictors.MethodsConducting a retrospective follow-up investigation, the study took place at Debre Berhan Comprehensive Specialized Hospital from January 1st, 2020 to December 31st2022, involving a sample size of 330. The analysis included the computation of the Kaplan-Meier survival curve, the log-rank test, and the median time. Additionally, a multivariable Cox proportional hazard regression model was employed to determine the survival status.Resultsin this study, among the 330 participants (100%), a total of 270(81.8%) successfully survived throughout the entire cohort. Predictors are independent of each other, affecting the time to recovery and survival of asphyxiated neonates, encompassed prolonged labor (AHR: 0.42, 95%CI:0.21-0.81), normal birth weight (AHR:2.21, 95% CI: 1.30-3.70),non-altered consciousness (AHR:2.52, CI:1.50-4.24), non-depressed moro reflex of the newborn (AHR:2.40, 95%CI: 1.03-5.61), stage I HIE (AHR: 5.11, 95% CI: 1.98-13.19), and direct oxygen administration via the nose (AHR: 4.18, 95% CI: 2.21-7.89).ConclusionThe duration for recovery seems to be slightly prolonged in comparison to other research findings. This underscores the significance of vigilant monitoring, early preventive interventions, and swift actions to avert the progression of infants to the most severe stage of HIE.

show abstract

Clinical Profile and Outcome of Asphyxiated Newborn in a Medical College Teaching Hospital

Cited by 7 publications

References 4 publications

Acute Renal Failure in Newborns with Birth Asphyxia

Acute Renal Failure in Newborns with Birth Asphyxia

Prevalence of Perinatal Asphyxia in Neonates at a Tertiary Care Hospital: A Descriptive Cross-sectional Study

Time to recovery of asphyxiated neonates and it’s predictors among newborns admitted to neonatal intensive care unit at Debre Berhan Comprehensive Specialized Hospital, Ethiopia

Contact Info

Product

Resources

About