2018
DOI: 10.4103/sjmms.sjmms_80_17
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Clinical profile and outcome of parathyroid adenoma-associated pancreatitis

Abstract: Background:Primary hyperparathyroidism due to parathyroid adenoma presenting with pancreatitis as the initial manifestation is rare. The causal relationship between pancreatitis and primary hyperparathyroidism is debatable.Objective:To study the clinical and biochemical profile of patients with parathyroid adenoma-associated pancreatitis as well as the outcome following parathyroidectomy.Methods:The authors retrospectively studied the clinical and biochemical parameters of patients with acute, recurrent acute … Show more

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Cited by 11 publications
(12 citation statements)
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“…9,11-13 with acute, recurrent, and chronic forms of pancreatitis reported. 2 Factors precipitating pancreatitis in cases with PHPT include hypercalcemia-mediated pancreatic duct stone formation and activation of intrapancreatic trypsinogen to trypsin, both of which lead to parenchymal injury. 2 Genetic predisposition may explain the development of pancreatitis only in a subset of patients with PHPT.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…9,11-13 with acute, recurrent, and chronic forms of pancreatitis reported. 2 Factors precipitating pancreatitis in cases with PHPT include hypercalcemia-mediated pancreatic duct stone formation and activation of intrapancreatic trypsinogen to trypsin, both of which lead to parenchymal injury. 2 Genetic predisposition may explain the development of pancreatitis only in a subset of patients with PHPT.…”
Section: Discussionmentioning
confidence: 99%
“… 2 Factors precipitating pancreatitis in cases with PHPT include hypercalcemia-mediated pancreatic duct stone formation and activation of intrapancreatic trypsinogen to trypsin, both of which lead to parenchymal injury. 2 Genetic predisposition may explain the development of pancreatitis only in a subset of patients with PHPT. 11 , 14 The prevalence of pancreatitis in PHPT ranges from 6.8 to 15 percent in the Indian population compared to 3.2 to 8.1 percent in the Western population.…”
Section: Discussionmentioning
confidence: 99%
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“…Most patients with PHPT are asymptomatic and it is detected upon routine laboratory testing. Clinical manifestations in patient with PHPT secondary to hypercalcemia include recurrent renal calculi, skeletal manifestations, nonspecific gastrointestinal symptoms, cardiovascular and neuromuscular disorders [2,3,11] . Acute pancreatitis is an inflammatory pancreatic process with high morbidity and mortality [9] .…”
Section: Case Presentationmentioning
confidence: 99%
“…Among other causes, hypercalcemia associated with acute pancreatitis is rare [2] . Primary hyperparathyroidism (PHPT) with subsequent hypercalcemia caused by parathyroid adenoma causing pancreatitis as the first manifestation is exceptionally rare with debatable and controversial association [3,4] . Although, it is though that elevated parathyroid hormone and high serum calcium levels associated with certain genetic mutations could be responsible for this predisposition in some patients with hyperparathyroidism causing calcium deposit in the pancreatic ducts which then activates the pancreatic enzymes [1,5,6] .…”
Section: Introductionmentioning
confidence: 99%