Clinical profile and outcome of cerebral venous sinus thrombosis at tertiary care center

Abstract

Background:Thrombosis of the cerebral venous sinuses (CVST) is an uncommon form of stroke, usually affecting young individuals. Clinical features of CVST are diverse, and for this reason, high degree of clinical suspect is mandatory to diagnose the conditions.Materials and Methods:This study was conducted over a period of 1 year (Jan 2011 to Dec 2011). This was a retrospective, observational, and noninterventional study. This study was conducted in the Department of Medicine at a tertiary care teaching center. Total 50 patients where diagnosis of CVST was confirmed by computed tomography/magnetic resonance imaging brain venogram were included in this study. All patients with diagnosis of CVST were treated according to the standard protocol and guidelines.Statistical Analysis:The mean and standard deviation were obtained. The Chi-square test was used to analyze the data and P < 0.05 was considered as statistically significant.Results:Of total 50 patients with diagnosis of CVST, 21 (42%) were males and 29 (58%) were females with 39 ± 10 years and 29 ± 7 years, respectively. Total 45 (90%) patients presented with symptoms of headache and vomiting, 13 (26%) had seizures, 12 (24%) had hemiplegia, and 19 (38%) had fever. A total of 13 (26%) patients had papilledema on fundoscopy. Total 9 (31%) out of 29 patients had diagnosis of CVST during peripartum period. Total 12 (24%) patients had hyperhomocysteinemia. Total 23 (46%) patients had sagittal sinus thrombosis, 10 (20%) had multiple sinus thrombosis, 16 (32%) had sigmoid/transverse sinus thrombosis. There was 1 (2%) patient who had bilateral cavernous sinus thrombosis, who presented with bilateral proptosis, conjunctival congestion, and external ophthalmoplegia with a history of acute or chronic maxillary and sphenoid sinusitis. Total 38 patients had evidence of infection in the form of fever, paranasal sinus (PNS) infections, Chronic suppurative otitis media (CSOM). Total 19 (38%) patients had a history and evidence of dehydration. Total 8 (16%) patients died during the course of treatment and 42 (84%) were discharged with partial and/or total recovery. Three (6%) patients required neurosurgical intervention in the form of decompressive craniotomy. Eight (16%) patients died with cerebral edema with transtentorial herniation. The mean age of death in male was significantly greater than in female patients with P < 0.02. Majority of patients succumbed had sigmoid, transverse, and/or multiple sinus involvement. Patients with multiple sinus thrombosis had greater case fatality rate.Conclusions:The current study highlights the burden of CVST in the study population with headache and vomiting, which was the most common presenting complaint. The superior sagittal sinus thrombosis was the most common and bilateral cavernous sinus thrombosis was the uncommon affection in CVST. One third of female population was affected in peripartum period. The infection and/or dehydration was the most commonly associated precipitating event for development of CVST and more than one fifth of ...

Cerebrovascular Accidents as a Cause of New Onset Seizure and Its Correlation with Age of Onset

“…The estimated proportion of the general population with active epilepsy at a given time is between 4 to 10 per 1000 people. However, some of the studies from developing countries suggest that the proportion is between 6 to 10 per 1000 2 3 In the prospective study patients with an intracerebral hemorrhage were found to have a higher incidence of seizures (10.6%) than those with an ischemic stroke (8.6%), while in those with a subarachnoid bleeding the incidence was similar to that in patients with a brain infarction. A low incidence of 2.5% of seizures was observed in patients with lacunar strokes.…”

Empty Sella and Sagittal Sinus Thrombosis in a Woman with Subaortic Stenosise

“…Cerebral Venous Thrombosis (CVT) is relatively uncommon, but with significant neurological sequels and up to 20% of mortality [1,2]. Because of the unspecific manifestations, clinical suspicion is challenging and imaging studies are needed to establish early diagnosis and adequate control [1][2][3].…”

“…CVT cab be confirmed by images of triangle and empty delta signs, and loss of flow void [1,10,11]. CVTs are less common than arterial thromboses, but under diagnosis occur without imaging evaluations; arterial stroke and other benign and malignant disorders are differential diagnosis [1][2][3].…”

“…Secondary IH (SIH) may be due to tumor, infection, obstruction of CSF flow, and arteriovenous fistula [1][2][3][6][7][8][9][10]. CVT cab be confirmed by images of triangle and empty delta signs, and loss of flow void [1,10,11].…”

“…Hypertension (IH) and main symptoms are headaches, seizures, and hemiparesis; major neuroimaging signs are brain edema, cerebral hematoma and subarachnoid hemorrhage [1][2][3][4][5]. Secondary IH (SIH) may be due to tumor, infection, obstruction of CSF flow, and arteriovenous fistula [1][2][3][6][7][8][9][10].…”