Clinical profile and outcome of solid pseudopapillary neoplasm of the pancreas: A retrospective study on 28 patients

Dhali, Arkadeep; Ray, Sukanta; Das, Somak; Mondal, Tuhin Subhro; Khamrui, Sujan; Gupta, Arunesh; Ansari, Zuber; Ghosh, Ranajoy; Dhali, Gopal Krishna

doi:10.1016/j.ijsu.2022.106708

Cited by 5 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, 51.8% of patients were asymptomatic, while the most common clinical symptoms were abdominal pain and distension. Jaundice is rarely in SPN patients ( 12 , 30 , 31 ), and our study found only one patient with a tumor located in the head of the pancreas who developed jaundice. Laboratory tests are usually normal and most tumor markers are negative ( 24 , 32 ).…”

Section: Discussionmentioning

confidence: 49%

Solid pseudopapillary neoplasm of the pancreas: a retrospective study of 195 cases

Fu,

Li,

Wang

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveSolid pseudopapillary neoplasm of the pancreas (SPN) is a rare exocrine tumor of the pancreas. The aim of our study is to summarize the clinical features of SPN and to analyze the risk factors for malignant SPN.MethodsFrom May 2013 to September 2022, patients who were pathologically confirmed to have SPN were retrospectively reviewed. Demographic data, clinical and pathological features, follow-up data were collected and analyzed. To investigate the factors influencing the benign or malignant nature of SPN, we employed logistic regression. Additionally, we utilized Kaplan-Meier curves to depict and analyze the overall prognosis.ResultsA total of 195 patients were included, 163 of whom were female and the average age of all patients was 31.7 years old. Among 195 patients, 101 patients (51.8%) had no obvious clinical symptoms and their pancreatic lesions were detected during routine examination. The primary symptom was abdominal pain and distension in 64 cases (32.8%). The maximum diameter of SPN tumors ranged from 1-17 cm (mean 6.19 cm). Forty-eight postoperative complications developed in 43 (22.1%) patients. After a median follow-up duration of 44.5 months, the overall 5-year survival rate was 98.8% and the recurrence rate was 1.5%. Furthermore, we observed a statistically significant difference in the completeness of the tumor capsule between benign and malignant SPN.ConclusionSPN is associated with a favorable long-term survival after surgery in our large sample size cohort. For malignant SPN, tumor capsule incompleteness is an independent risk factor.

show abstract

Section: Discussionmentioning

confidence: 49%

Solid pseudopapillary neoplasm of the pancreas: a retrospective study of 195 cases

Fu,

Li,

Wang

et al. 2024

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…SPNs are uncommon tumors and predominantly seen in young female patients for as-yet-unknown reasons. Most SPN patients are asymptomatic at diagnosis with abdominal pain as the most common symptom[ 13 ]. SPNs are likely to be large at presentation with a mean size of 9 cm (range: 2.5-17.0 cm) and a well-defined margin, which can be found throughout the pancreas.…”

Section: Discussionmentioning

confidence: 99%

Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography

Ren,

Qian,

et al. 2024

World J Radiol

View full text Add to dashboard Cite

BACKGROUND Solid pseudopapillary neoplasms of the pancreas (SPN) share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes (PDAC with cystic changes), which may result in unnecessary surgery. AIM To investigate the value of computed tomography (CT) in differentiation of SPN from PDAC with cystic changes. METHODS This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes, confirmed through pathological diagnosis. Quantitative and qualitative analysis was performed, including assessment of age, sex, tumor size, shape, margin, density, enhancement pattern, CT values of tumors, CT contrast enhancement ratios, “floating cloud sign,” calcification, main pancreatic duct dilatation, pancreatic atrophy, and peripancreatic invasion or distal metastasis. Multivariate logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes, and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their combination. RESULTS When compared to PDAC with cystic changes, SPN had a lower age (32 years vs 64 years, P < 0.05) and a slightly larger size (5.41 cm vs 3.90 cm, P < 0.05). SPN had a higher frequency of “floating cloud sign” and peripancreatic invasion or distal metastasis than PDAC with cystic changes (both P < 0.05). No significant difference was found with respect to sex, tumor location, shape, margin, density, main pancreatic duct dilatation, calcification, pancreatic atrophy, enhancement pattern, CT values of tumors, or CT contrast enhancement ratios between the two groups (all P > 0.05). The area under the receiver operating characteristic curve of the combination was 0.833 (95% confidence interval: 0.708-0.957) with 78.6% sensitivity, 81.3% specificity, and 80.4% accuracy in differentiation of SPN from PDAC with cystic changes. CONCLUSION A larger tumor size, “floating cloud sign,” and peripancreatic invasion or distal metastasis are useful CT imaging features that are more common in SPN and may help discriminate SPN from PDAC with cystic changes.

show abstract

“…Some studies have shown that 18 F-FDG PET/CT has significant value in the diagnosis, prognosis, and recurrence assessment of thymoma 2–4 . Solid pseudopapillary neoplasm is a relatively rare low-grade malignant tumor that can occur anywhere in the pancreas 5,6 . Solid pseudopapillary neoplasm should be differentiated from acinar cell carcinoma, 7 serous cystadenoma, 8 mucinous cystadenoma, 9 and neuroendocrine tumor 10 .…”

mentioning

confidence: 99%

“…[2][3][4] Solid pseudopapillary neoplasm is a relatively rare low-grade malignant tumor that can occur anywhere in the pancreas. 5,6 Solid pseudopapillary neoplasm should be differentiated from acinar cell carcinoma, 7 serous cystadenoma, 8 mucinous cystadenoma, 9 and neuroendocrine tumor. 10 68 Ga-labeled FAPI has recently been introduced as a promising tumor imaging agent.…”

mentioning

confidence: 99%

68Ga-FAPI-04 PET/CT in the Detection of Non–FDG-Avid Solid Pseudopapillary Neoplasm of the Pancreas

et al. 2023

View full text Add to dashboard Cite

Solid pseudopapillary neoplasm of the pancreas is a rare tumor. A 46-year-old woman presented with chest pain for 6 months. Chest CT revealed a large mass of the right mediastinum. Then, she underwent 18 F-FDG and 68 Ga-FAPI-04 PET/CT scans for staging. However, we accidentally found that a non-FDG focus nodule in the body of the pancreas with elevated FAPI activity. Finally, biopsy of the nodule in the body of the pancreas confirmed the diagnosis of solid pseudopapillary neoplasm.

show abstract

Clinical profile and outcome of solid pseudopapillary neoplasm of the pancreas: A retrospective study on 28 patients

Cited by 5 publications

References 36 publications

Solid pseudopapillary neoplasm of the pancreas: a retrospective study of 195 cases

Solid pseudopapillary neoplasm of the pancreas: a retrospective study of 195 cases

Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography

68Ga-FAPI-04 PET/CT in the Detection of Non–FDG-Avid Solid Pseudopapillary Neoplasm of the Pancreas

Contact Info

Product

Resources

About