Clinical profile and outcomes of coronavirus disease 2019 (COVID-19) in patients undergoing hemodialysis

Lamech, Tanuj Moses; Nithya, Govindasamy; Aiswarya, Dhanapalan; Gopalakrishnan, Natarajan; Vathsalyan, Paulpandian; Shaji, S.; Goutham, Kamalakannan; Krishna, R; Dineshkumar, Thanigachalam; Sakthirajan, Ramanathan; Dhanapriya, J; Rajendran, P. Selvi

doi:10.4103/ijn.ijn_511_20

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Despite the scarcity of data on the impact of SARS-CoV-2 infection on maintenance hemodialysis (MHD) patients, a retrospective observational study conducted at a single center in Greece highlighted 32 MHD patients infected with the Omicron variant, resulting in a mortality rate of 15.6%. [6] Another study involving 183 MHD patients reported an overall mortality rate of 13.1, [7] surpassing the reported 2% mortality rate in the general population. [8] However, comprehensive insights into the clinical characteristics, diagnosis, and treatment of SARS-CoV-2 Omicron lineage variants in adult MHD patients, particularly those unimmunized, remain limited and warrant further clarification.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study

Ha,

Zhao,

Zhao

et al. 2024

Integr Med Nephrol Androl

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Background: Maintenance hemodialysis (MHD) patients constitute a distinctive population characterized by unique traits, such as hemodialysis-related immune disturbances, and increased vulnerability to infections, heart failure, particularly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Despite considerable research on MHD patients with coronavirus disease 2019 (COVID-19), there is limited information available on the clinical characteristics and outcomes of unvaccinated adult MHD patients infected with the SARS-CoV-2 Omicron variant. Methods: A retrospective investigation was conducted in a cohort of 427 unvaccinated MHD patients diagnosed with SARS-CoV-2 Omicron infection. The clinical symptoms, laboratory results, and treatment regimens were comprehensively examined. Multivariate regression identified independent risk factors for disease severity, and two-month follow-up assessments were conducted. Results: The cohort exhibited a spectrum of disease severity, with 37.5% classified as mild, 35.3% as common, 22.5% as severe, and 4.7% as critical. Serum C-reactive protein level, procalcitonin level, and bicarbonate concentration are related to the severity of the disease. Tailored treatment strategies—including nutritional support, hemodialysis management, anti-bacterial interventions, and more—were implemented. There was a 5.6% mortality rate, with a higher prevalence of deaths in the critical subtype. Independent risk factors for disease severity included fever, age, cycle threshold values (Ct values) of ORF1ab gene, and arterial oxygen partial pressure. Follow-up assessments revealed a median duration of 11 days for the negative nucleic acid of SARS-CoV-2. Twelve patients presented a second positive ORF1ab gene during follow-up but remained asymptomatic. Conclusion: These findings suggest the intricate clinical characteristics and outcomes of MHD patients with the SARS-CoV-2 Omicron infection. Tailored treatment strategies, continuous surveillance, and understanding prognostic factors are imperative for managing this high-risk population. Further research is warranted to validate these findings.

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Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study

Ha,

Zhao,

Zhao

et al. 2024

Integr Med Nephrol Androl

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“…The MHD patients are a special group of patients with a higher risk of electrolyte disorders. COVID-19 infection may further increase the risk of electrolyte disorders in hemodialysis patients 8 , 9 . However, there is currently limited research on the association between serum potassium variability and the risk of all-cause death and cardiovascular disease (CVD) in MHD patients after COVID-19 infection.…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Potassium Variability With 60-day Mortality and Cardiovascular Events after COVID-19 Infection in Maintenance Hemodialysis Patients

Feng,

Li,

Hao

et al. 2024

Int. J. Med. Sci.

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Objective: This study aimed to investigate the association between serum potassium variability and 60-day mortality and cardiovascular disease (CVD) in maintenance hemodialysis (MHD) patients following the coronavirus disease 2019 (COVID-19) infection. Methods: We conducted a retrospective study on MHD patients treated at the affiliated hospital of Qingdao University hemodialysis center who were infected with the novel coronavirus between December 1, 2022, and January 31, 2023. Baseline characteristics of patients were collected from electronic medical records. Kaplan-Meier survival analysis was used to obtain patient survival probabilities, and multivariate Cox hazard regression models and binary Logistic regression models were used to obtain hazard ratios (HR), odds ratios (OR), and 95% confidence intervals (95% CI) between exposure and outcomes. Results: A total of 296 patients were included in this study, with a mean age of 57.2±16.3 years, and 59.8% were male. The 60-day mortality rate was 10.8%, and the incidence of CVD was 32.8%. Kaplan-Meier curves showed that a higher potassium variability coefficient was associated with higher all-cause mortality ( P = 0.024). After adjusting for potential confounders, multivariate Cox regression analysis showed that the HR for 60-day mortality in the Q4 group compared to the Q1 group was 2.06 (95% CI = 1.03-4.09, P = 0.040), and binary Logistic regression analysis showed that the OR for 60-day CVD in the Q4 group compared to the Q1 group was 4.09 (95% CI = 1.52-10.97, P = 0.005). Conclusion: Increased serum potassium variability in MHD patients after COVID-19 infection significantly increased the likelihood of 60-day mortality and CVD.

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“…Since the outbreak of COVID-19, data on the impact of SARS-CoV-2 infection on MHD patients remain scarce, with a single foreign center report showing 32 MHD patients infected with Omicron, with a mortality rate of 15.6% [6] . Results of a study of 183 MHD patients showed that the overall mortality rate was 13.1% [7] , higher than the reported mortality rate of 2% in the general population [8] . However, the clinical characteristics, diagnosis, and treatment of SARS-CoV-2 Omicron BA.5.2 lineage variant in adult MHD, especially in unimmunized patients, are still few and need to be further clari ed.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis infected with SARS-CoV-2 Omicron subvariant BA.5.2

Cao

Zhao

et al. 2023

Preprint

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To analyze the clinical characteristics and outcomes of unvaccinated adult patients on maintenance hemodialysis infected with SARS-CoV-2 Omicron subvariant BA.5.2.The clinical data of 427 maintenance hemodialysis patients infected with SARS-CoV-2 Omicron subvariant BA.5.2 in our hospital were retrospectively collected. The patients were grouped according to the severity of the disease and compared. The clinical outcome and two-month follow-up were analyzed.These results suggest that CRP level, procalcitonin level, and bicarbonate concentration are related to the severity of disease caused by SARS-CoV-2 omicron BA.5.2 infection in unimmunized MHD patients. In addition, the co-bacterial infection may be an important cause of severe illness. Therefore, strengthen the treatment of critically ill patients, and actively and effectively control infection and secondary infection; Effective vaccination is the key to improving clinical outcomes to prevent the conversion of ordinary patients to severe and critical cases. Fever, age, ORF1ab gene value, and arterial oxygen partial pressure may be independent risk factors for disease severity in COVID-19 patients.

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Clinical profile and outcomes of coronavirus disease 2019 (COVID-19) in patients undergoing hemodialysis

Cited by 4 publications

References 15 publications

Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study

Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis Infected with the SARS-CoV-2 Omicron Variant: A Retrospective Study

Association of Serum Potassium Variability With 60-day Mortality and Cardiovascular Events after COVID-19 Infection in Maintenance Hemodialysis Patients

Clinical Characteristics of 427 Unvaccinated Chinese Adult Patients with Maintenance Hemodialysis infected with SARS-CoV-2 Omicron subvariant BA.5.2

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