Clinical profile and outcomes of Non-Hodgkin's lymphoma in children: A report from a tertiary care hospital from India

Meena, Jagdish Prasad; Gupta, Aditya; Parihar, Mansingh; Seth, Rachna

doi:10.4103/ijmpo.ijmpo_70_18

Cited by 8 publications

(3 citation statements)

References 33 publications

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“…5 Most patients of HL usually present with B symptoms (fever, drenching night sweats and loss of more than 10% of weight in the last 6 months), while NHL patients present commonly with abdominal swelling followed by lymphadenopathy. 14,15 In this study, lymphadenopathy was the most common presentation in both HL and NHL patients. These patients are often misdiagnosed as tuberculosis that leads to advanced stage at diagnosis.…”

Section: Discussionmentioning

confidence: 67%

Clinicodemographic Profile of Childhood Cancer in a Mining State, Odisha: A Retrospective Analysis

Samanta¹,

Avinash²,

Senapati³

et al. 2023

Indian J Med Paediatr Oncol

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Introduction Pediatric malignancy represents 5% of total cancer diagnosed in India. Due to delayed diagnosis and inaccessibility to healthcare system, the overall outcome is poor in our country. The clinicodemographic profile of childhood malignancy is well described in the Western world and in certain parts of India. The incidence of pediatric malignancy in Eastern India, especially Odisha, has not yet been reported that has motivated us to conduct such a study. Objective This study aims to evaluate the clinicodemographic profile and pattern of childhood malignancy among pediatric patients who received the treatment at a tertiary cancer institute of Odisha. Materials and Methods It was a retrospective observational study, carried out for a period of 8 years, from January 1, 2013 to December 31, 2020 at a tertiary cancer center in Eastern India. A total of 759 eligible childhood malignancy patients were recruited in the study. IBM SPSS v23 was used for descriptive statistical analysis, that is, number and percentage of various clinicodemographic parameters of the above patients. Result Childhood malignancy accounted for 1.6% of all cancers reported during the above study period. The male to female ratio was 1.8:1. Out of 759 eligible childhood cancer patients, majority of patients were suffering from leukemia (173; 22.8%) followed by malignant bone tumors (137; 18.0%), and lymphoma (122; 16%). Leukemia was predominant in the age group of 0 to 14 years; lymphoma, central nervous system neoplasms, germ cell tumors malignant bone tumors, and soft tissue sarcoma (STS) were common in the age group of 10 to 18 years; neuroblastoma, retinoblastoma, and renal and hepatic tumors were seen commonly in the age group of 0 to 9 years. The most common presentation in leukemia was fever, while lymphadenopathy was the chief complaint in lymphoma. Local swelling and pain were the presenting symptoms in malignant bone tumors, while STS patients had painless swelling. Conclusion This study provides an overview of the burden and pattern of childhood malignancy for the state of Odisha and acts as a roadmap for the clinicians to conduct further research in the field of pediatric oncology.

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Section: Discussionmentioning

confidence: 67%

Clinicodemographic Profile of Childhood Cancer in a Mining State, Odisha: A Retrospective Analysis

Samanta¹,

Avinash²,

Senapati³

et al. 2023

Indian J Med Paediatr Oncol

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“…15 studies [ 9 , 21 , 24 – 27 , 32 , 34 , 39 – 41 , 44 , 49 – 52 ] ( n = 4258, range per study n = 18 to 2326) reported on the symptoms and signs for non-Hodgkin’s lymphoma. These included organomegaly (34% [95% CI 22%-48%]), B-symptoms (38% [95% CI 31%-44%]), cervical lymphadenopathy (28% [95% CI 17%-42%]), peripheral lymphadenopathy (45% [95% CI 31%-61%]), fever (47% [95% CI 35%-61%]), weight loss (58% [95% CI 41%-72%]), abdominal pain (29% [95% CI 12%-54%]) (Fig.…”

Section: Resultsmentioning

confidence: 99%

Presentation of B-cell lymphoma in childhood and adolescence: a systematic review and meta-analysis

Saatci,

Zhu,

Harnden

et al. 2024

BMC Cancer

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Background The diagnosis of B-cell lymphoma, one of the commonest cancers seen in childhood and adolescence, is challenging. There is a crucial need to identify and delineate the prevalence of associated symptoms in order to improve early diagnosis. Aims To identify clinical presentations associated with childhood and adolescent B-cell lymphomas and estimate symptom prevalence. Methods A systematic review of observational studies and meta-analysis of proportions was carried out. Medline and EMBASE were systematically searched, with no language restrictions, from inception to 1st August 2022. Observational studies with at least 10 participants, exploring clinical presentations of any childhood and adolescent lymphoma, were selected. Proportions from each study were inputted to determine the weighted average (pooled) proportion, through random-effects meta-analysis. Results Studies reported on symptoms, signs and presentation sites at diagnosis of 12,207 children and adolescents up to the age of 20. Hodgkin’s lymphoma most frequently presented with adenopathy in the head-and-neck region (79% [95% CI 58%-91%]), whilst non-Hodgkin’s lymphoma presented abdominally (55% [95% CI 43%-68%]). Symptoms associated with lymphoma included cervical lymphadenopathy (48% [95% CI 20%-77%]), peripheral lymphadenopathy (51% [95% CI 37%-66%]), B-symptoms (40% [95% CI 34%-44%]), fever (43% [95% CI 34%-54%]), abdominal mass (46% [95% CI 29%-64%]), weight loss (53% [95% CI 39%-66%]), head-and-neck mass (21% [95% CI 6%-47%]), organomegaly (29% [95% CI 23%-37%]), night sweats (19% [95% CI 10%-32%]), abdominal pain (28% [95% CI 15%-47%]), bone pain (17% [95% CI 10%-28%]) and abnormal neurology (11% [95% CI 3%-28%]). Conclusion This systematic review and meta-analysis of proportions provides insight into the heterogeneous clinical presentations of B-cell lymphoma in childhood and adolescence and provides estimates of symptom prevalence. This information is likely to increase public and clinical awareness of lymphoma presentations and aid earlier diagnosis. This review further highlights the lack of studies exploring childhood and adolescent lymphoma presentations in primary care, where patients are likely to present at the earliest stages of their disease.

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“…During the assessment and diagnostic approaches of suspected children with NHL, some pathological conditions like vena cava obstruction, acute airway obstruction, intestinal obstruction, spinal cord compression, pericardial tamponade, lymphomatous meningitis, hyperuricemia, tumor lysis syndrome, ureteral obstruction, unilateral or bilateral hydronephrosis, venous thromboembolic disease, and a potential emergency complication of NHL may be present [ 12 ]. Because some of those are fetal and may cause death during the initial stage of treatment, those initial parameters are important and documented.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review on Childhood Non-Hodgkin Lymphoma: An Overlooked Phenomenon in the Health and Research Sector of Bangladesh

Britto,

Fattah,

Rahman

et al. 2023

Cureus

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Globally, childhood cancer, particularly non-Hodgkin lymphomas (NHLs), is a prevalent concern. However, the difficulty becomes even more distressing in lower-middle-income nations such as Bangladesh. The insufficiency of research, resources, inadequate guidelines, expensive treatment costs, and specialized knowledge exacerbate the challenges associated with the treatment of certain types of cancers. Our investigation looked extensively into the circumstances prevailing in Bangladesh, with the objective of providing a comprehensive overview of the current status and approaches to managing NHL in the country. Through this work, our intention was to illuminate the domains that require immediate focus and assistance. To get insight into the present state of NHL in Bangladesh, our analysis focused on a selection of seven research articles and two case reports published between 2018 and 2023. In order to ensure the integrity and consistency of our review, we conducted a detailed selection procedure, employing the systematic PRISMA review methodology. From a pool of 294 papers, we selected the ones that met our predetermined criteria. These papers were sourced from reputable academic databases, such as Google Scholar and PubMed. The findings of our study indicate a higher prevalence of NHL among children in Bangladesh compared to Hodgkin lymphoma (HL). Additionally, this phenomenon exhibits a higher prevalence among male individuals. Our study revealed that in Bangladesh, there is a lack of a dedicated guideline or research center specifically focused on NHL. Additionally, the number of research centers and research dedicated to cancer treatment as a whole is limited. Our research aims to offer a complete analysis of NHL in the context of Bangladesh, with the intention of offering valuable guidance to healthcare professionals and policymakers. The utilization of our research outcomes has the potential to enhance patient care, facilitate the development of more effective clinical protocols, and promote greater accessibility and affordability of therapies. This has the potential to provide improved cancer care not only in Bangladesh but also in other comparable contexts worldwide.

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Clinical profile and outcomes of Non-Hodgkin's lymphoma in children: A report from a tertiary care hospital from India

Cited by 8 publications

References 33 publications

Clinicodemographic Profile of Childhood Cancer in a Mining State, Odisha: A Retrospective Analysis

Clinicodemographic Profile of Childhood Cancer in a Mining State, Odisha: A Retrospective Analysis

Presentation of B-cell lymphoma in childhood and adolescence: a systematic review and meta-analysis

A Systematic Review on Childhood Non-Hodgkin Lymphoma: An Overlooked Phenomenon in the Health and Research Sector of Bangladesh

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