Clinical profile and response in patients with megaloblastic anemia

Pandya, Hiren P; Patel, Asit

doi:10.5455/ijmsph.2016.13032015126

Cited by 9 publications

(8 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pandya H et al found the Incidence of megaloblastic anemia highest in the age between 40 and 49 years. 16 In the present study, male preponderance was observed in megaloblastic anemia. Similar finding was observed by Daljinder Kaur et al, Pandya et al 17,16 Other studies observed female preponderance in megaloblastic anemia.…”

Section: Discussionsupporting

confidence: 54%

“…16 In the present study, male preponderance was observed in megaloblastic anemia. Similar finding was observed by Daljinder Kaur et al, Pandya et al 17,16 Other studies observed female preponderance in megaloblastic anemia. 18,19 In the present study, the mean serum LDH level was found to be highest in megaloblastic anemia with LDH activity showing 19 times increase as compared to control.…”

Section: Discussionsupporting

confidence: 54%

See 1 more Smart Citation

Utility of serum lactate dehydrogenase in the diagnosis of megaloblastic anemia

Gaikwad

Jadhav

2018

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Megaloblastc anemia corresponds to severe macrocytic anemia with hypersegmented neutrophils and very high serum Lactate Dehydrogenase (LDH). The present study was undertaken to evaluate the utility of serum LDH and chloroform inhibited serum LDH in the diagnosis of megaloblastic anemia and to observe if this can be used to differentiate megaloblastic anemia from iron deficiency anemia and hemolytic anemia.Methods: The present study was carried out on 75 patients of anemia categorised on bone marrow examination (into megaloblastic and non-megaloblastic anaemia) to evaluate the efficacy of total serum LDH levels and LDH isoenzyme pattern in the diagnosis of megaloblastic anemia. About 25 healthy adults were taken as controls.Results: In megaloblastic anemia, total serum LDH level was found to be increased to about nineteen folds and in hemolytic anemia it was found to increased four folds as compared to normal. On statistical analysis this increased total serum LDH level in megaloblastic anemia and hemolytic anemia as compared to control group was found to be significant.In the present study serum LDH level above 3000IU/L was associated with megaloblastic anemia and serum LDH level below 900IU/L was suggestive of iron deficiency anemia. The chloroform inhibition test was less than 25% in megaloblastic anemia and more than 25% in hemolytic anemia and these differences were found to be statistically significant (t=9.62, df=49, p<0.001).Conclusions: Total serum LDH levels more than 3000IU/L are diagnostic of megaloblastic anemia. Reversed LDH isoenzyme pattern (LDH1>LDH2) by chloroform inhibition test is an adjuvant in the diagnosis where total serum LDH levels are between 451-3000IU/L and can also differentiate megaloblastic anemia from hemolytic anemia.

show abstract

Section: Discussionsupporting

confidence: 54%

Section: Discussionsupporting

confidence: 54%

Utility of serum lactate dehydrogenase in the diagnosis of megaloblastic anemia

Gaikwad

Jadhav

2018

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…These results were in contrast with findings of a study by Pandya et al, which showed that males were more affected from megaloblastic anemia than the females and showed peak incidence in age groups of 40-49 years which is a much older age group than our study findings. 13 A similar study to our study results were a study by Amrapal et al, which found a peak age incidence in megaloblastic patients between age groups of 11-40 years 2. The difference of gender between our study and these studies might be due to cultural differences.…”

Section: Discussionsupporting

confidence: 92%

Diagnostic Utility of Serum Lactate Dehydrogenase Levels (Ldl) in Differentiating Megaloblastic Anemia From Myelodysplastic Syndromes in Pakistan

Rana

Robert

Ilyas

et al. 2021

PAFMJ

View full text Add to dashboard Cite

Objective: To study the diagnostic utility of lactate dehydrogenase levels in differentiating megaloblastic anemia from myelodysplastic anemia in Pakistan. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Hematology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan from Feb, 2019 to Aug, 2019. Methodology: In this study, total 240 patients (18-75 years of age) males and females were selected by consecutive sampling technique and were equally divided into 3 groups; patients with megaloblastic anemia, patients with myelodysplastic syndromes and healthy control group. The clinical history and duration of anemia were recorded on special designed proforma. The laboratory investigations including lactate dehydrogenase levels were also noted. Both types of anemia were compared on basis of Lactate Dehydrogenase Levels. Results: The lactate dehydrogenase levels in megaloblastic group were more than 3000 IU/L in 58 out of 80 patients (72.5%). On other hand, myelodysplastic group had 79 out of 80 patients with lactic acid dehydrogenase levels below 450 IU/L (98.75%). The difference in lactic acid dehydrogenase levels between both groups was found to be statistically significant. Conclusion: Serum lactate dehydrogenase levels can be used to differentiate megaloblastic anemia from other anemia especially myelodysplastic syndromes before doing a bone marrow examination. High lactate dehydrogenase levels above 3000 IU/L in megaloblastic anemia can differentiate it from other anemia.

show abstract

“…Icterus similar to previous studies like the one by Pandya and Patel 14 where maximum patients were in the age group 40-49 years and an overall male preponderance was seen.…”

Section: Discussionsupporting

confidence: 90%

Role of LDH levels in differentiating anemias

Zaidi

Usmani²,

Tiwari

et al. 2021

Asian J Med Sci

View full text Add to dashboard Cite

Background: There is a need to differentiate megaloblastic anemia from mixed deficiency anemia as both require different management protocols. With the acquisition of more information about them, tests such as serum vitamin estimation and Schilling test, were found to have their limitations. Hence there is a need to search newer diagnostic candidates to differentiate between megaloblastic anemia and mixed deficiency anemia. Aims and Objective: The current study was undertaken to find usefulness of serum Lactate Dehydrogenase (LDH) in differentiating megaloblastic anemia from mixed deficiency anemia. Materials and Methods: 100 patients were included in the study. Blood smears were stained and analysed. Complete blood counts were performed. Bone marrow examination was done, where needed. Biochemical tests were performed for estimation of vitamin B12, Folate and for LDH. Results: Out of the 100 cases 51 were diagnosed as megaloblastic anemia and 49 were diagnosed as mixed deficiency anemia. The LDH levels were significantly higher in cases of megaloblastic anemia as compared to mixed deficiency anemia. Conclusion: Serum LDH levels can be used in differentiating megaloblastic anemia from mixed deficiency anemia.

show abstract

Clinical profile and response in patients with megaloblastic anemia

Cited by 9 publications

References 4 publications

Utility of serum lactate dehydrogenase in the diagnosis of megaloblastic anemia

Utility of serum lactate dehydrogenase in the diagnosis of megaloblastic anemia

Diagnostic Utility of Serum Lactate Dehydrogenase Levels (Ldl) in Differentiating Megaloblastic Anemia From Myelodysplastic Syndromes in Pakistan

Role of LDH levels in differentiating anemias

Contact Info

Product

Resources

About