Clinical profile and response to steroids in post-fever retinitis: a nine-year experience from a referral institute in the rural hinterland of Central India

Shenoy, Pratik; Kohli, Gaurav; Kerketta, Aarti; Pathak, Pushparaj Mani; Shetty, Sachin; Barde, Pradip V; Chakma, Tapas; Sen, Alok

doi:10.1007/s10792-021-01978-9

Cited by 8 publications

(2 citation statements)

References 23 publications

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“…1 ]. [ 1 - 3 ] Patients with positive WFT at the presentation who underwent a follow-up WFT during the course of the disease were included in the study. The test was considered positive at the cut-off value of 1:80 provided the titers decreased or increased in subsequent visits.…”

Section: Methodsmentioning

confidence: 99%

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Monitoring Weil–Felix test in epidemic retinitis

Kawali

Sanjay

Mahendradas

et al. 2022

Indian Journal of Ophthalmology

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Purpose: The objective was to study the positivity of the Weil–Felix test (WFT) in epidemic retinitis (ER) during the course of the disease. Methods: This is a retrospective, observational case series of patients diagnosed with ER and presented to a tertiary eye care hospital in south India. Patients with positive WFT at the presentation, and who underwent a follow-up WFT during or after the resolution of ER were studied from September 2019 to March 2022. Patient’s demographics, timings of clinical presentation and resolution, and investigation details with a special focus on WFT positivity and its duration were noted. Results: Sixteen patients were studied. Patients presented after 5 weeks of the fever (range: 2-12 weeks, median: 4). After 1-2 months, WFT was still positive in eight patients (50%). Only in one patient titers increased after 1 month, while in others, the titers decreased ( n = 11) or remained the same ( n = 4). Repeated tests in those patients ( n = 6) after 3-4 months turned negative. Resolution of ER was seen at 1.35 months (range: 1-3 months) after the presentation. The mean duration for WFT to turn negative was 2 months from the presentation (range: 1-4 months) or 3.2 months of the fever (range: 1.5-6 months). Conclusion: In contrast to the reported physician’s observation of increasing titers of WFT after rickettsial fever, ophthalmologists may observe decreasing WFT titers in ER. The clinical resolution of ER may precede the normalization of WFT. Follow-up WFT titers should be studied in larger series in confirmed cases of rickettsial-ER to validate the affordable and readily available WFT in India.

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Section: Methodsmentioning

confidence: 99%

“…Epidemic retinitis (ER) or post-fever retinitis is mainly reported in the Indian subcontinent. [ 1 - 3 ] This is an umbrella term that groups together retinitis caused by concurrent epidemics in the community like rickettsia, dengue, chikungunya, and West Nile virus. [ 4 ] In south India, rickettsial etiology could be prevalent as reported previously.…”

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confidence: 99%