Clinical Profile and Treatment Response of Patients with Ocular Inflammation due to Presumed Ocular Tuberculosis: A Retrospective Study

Abstract

Objectives:Ocular tuberculosis is an extrapulmonary tuberculous infection and has varying manifestations which pose a huge challenge to diagnosis and treatment. The purpose of this study is to describe the various clinical manifestations of ocular inflammations due to tuberculosis and to assess the response to treatment following antituberculous therapy (ATT) and corticosteroids in these patients.Materials and Methods:We performed a retrospective analysis of 29 patients with presumed ocular tuberculosis who were started on ATT and completed follow-up of at least 6 months after ATT was initiated. The data collected were: age at presentation, sex, laterality, presence or absence of pulmonary/extrapulmonary tuberculosis, history of exposure to tuberculosis, site of ocular involvement and duration of illness, visual acuity at presentation and at 6-month follow-up, and response to treatment.Results:Most of the patients were of economically productive age, between 21-60 years. This most common presentation in our study population was unilateral nongranulomatous anterior uveitis. In spite of the delay between symptom onset and start of therapy, favorable response was noted in 79.3% of patients at completion of 6 months of ATT. The various reasons for the delay in start of therapy were also evaluated.Conclusion:In this case series, we presented the various ocular manifestations and the difficulties faced in the diagnosis of presumed ocular tuberculosis. Outcomes of ATT were favorable in most of our patients. Thus, the clinician should exercise a very high degree of suspicion and should not withhold a trial of ATT.

Bacillary layer detachment in serpiginous-like choroiditis of presumed intraocular tuberculosis: Report of two cases

“…They reported splitting of the bacillary layer at the level of the myoid, the OCT findings of which were similar and corroborated to the BALAD seen in our cases. 6 , 9 , 11 , 15 …”

“…Unlike what one sees in the lesions of idiopathic SC, the tuberculous lesions tend to not recur after the ATT treatment. 9 , 10 …”

Presumed Ocular Tuberculosis: a Retrospective Case Review

“…Given its ability to often masquerade as an ocular in ammatory reaction without obvious tuberculoid correlation, as well as the fact that testing for ocular TB is generally limited to invasive, expensive, and less available de nitive diagnostic tests such as polymerase chain reaction (PCR) with ocular uid samples, early diagnosis of ocular TB is exceptionally di cult. Therefore, diagnosis of ocular TB is often made presumptively in concert with tuberculin skin tests and interferon gamma release assays after other possible etiologies have been excluded [10][11][12][13][14][15]. Favorable response to anti-tuberculosis therapy (ATT) may also indirectly serve as evidence further elucidating the potential diagnosis.…”

Adolesan Bir Hastada Granülomatöz Üveit ile Seyreden Oküler Tüberküloz: Nadir Bir Olgu Sunumu

“…The incidence of ocular tuberculosis was found to be 1.4% in a study conducted in 10.524 TB patients. [9,10] In the literature, case reports of pediatric patients are very rare.…”