Clinical profile of acute flaccid paralysis: A study from a tertiary care centre in Kashmir, India

Mohsin, Naveed; Asimi, Ravouf

doi:10.4103/0331-3131.189805

Cited by 5 publications

(6 citation statements)

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“…The findings of a study have shown that AFP incidence has been increased after N1H1vaccination. 22 Our findings indicated that the incidence of AFP was higher among males compared to females, which was consistent with many other published studies [23][24][25] , indicating that gender does affect the incidence rate of AFP. This can be explained by the fact that there are sex differences in the susceptibility to infectious agents.…”

Section: Discussionsupporting

confidence: 92%

“…33 In this study, GBS was the most common cause of AFP with a frequency of 74.5%, which is consistent with findings from other countries. 23 has been consistently reported as the most common cause of non-polio AFP in children younger than fifteen years over the last two decades worldwide, with a prevalence ranging from 15% of cases in Pakistan 25 to 83.5% of cases in Iran. 31 The reason for these variations may be attributed to surveillance sensitivity and possible differential diagnoses, hence an accurate diagnosis of the cause of GBS is important.…”

Section: Discussionmentioning

confidence: 99%

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Eleven-year surveillance of acute flaccid paralysis in southwestern Iran

2019

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Momen AA, Shakurnia A, Momen M. Eleven-year surveillance of acute flaccid paralysis in southwestern Iran. Turk J Pediatr 2019; 61: 544-551. The purpose of the study was to report the results of acute flaccid paralysis (AFP) surveillance in the southwestern Iran in the 11 years' period. This is a retrospective descriptive study based on WHO guidelines. The collected data includes all pediatric AFP cases reported between of January 2006 to December 2016 by all health centers of Khuzestan province in Southwest of Iran.During an eleven-year period, 274 cases of AFP were reported in Khuzestan Province. Among them, 56.9% were younger than five years of age, and 55.9% were male. None of these cases was confirmed as poliomyelitis. The annual incidence of non-polio AFP ranged from 1.46/100,000 to 3.11/100,000 (Mean: 2.04 cases/100,000). The incidence rate of AFP in children under five years of age was significantly higher compared to older children (p=0.001), and the most common cause of paralysis (74.5%) was Guillain-Barre syndrome. All performance indicators met the WHO-specified targets. The follow-up of patients with AFP is essential to the eradication of poliomyelitis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Eleven-year surveillance of acute flaccid paralysis in southwestern Iran

2019

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“…International studies of AFP seasonality are few in number and limited to geographic sub-regions. A review of paediatric and adult AFP cases in Kashmir, India found AFP was more frequent in Spring [23]. Our study showed an overall AFP seasonal predominance with ADEM being associated with an increased frequency in winter.…”

Section: Afp Surveillance Trendssupporting

confidence: 50%

Acute Flaccid Paralysis in Australian Children from 2007 to 2017

et al. 2022

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Introduction: Acute flaccid paralysis (AFP) surveillance continues globally as part of the World Health Organization’s goal to eradicate poliomyelitis. The Australian Paediatric Surveillance Unit (APSU), Paediatric Active Enhanced Disease Surveillance (PAEDS) network, and National Enterovirus Reference Laboratory (NERL) collaborate in acute flaccid paralysis surveillance in Australia, capturing and reviewing cases of AFP for all etiologies in order to exclude poliovirus. . We aimed to describe the AFP epidemiology in childhood over an eleven year period. Methods: Data were reported nationally by paediatricians via prospective APSU surveillance, PAEDS surveillance nurses at five tertiary paediatric hospitals and NERL from 2007 to 2017. Children aged 0-15 years with AFP were included. We combined APSU, PAEDS and NERL datasets, analysed epidemiological trends and described clinical features and investigations for major diagnoses. Results: Of 590 AFP-compatible cases, 49% were male; 47% were aged 0-4 years, 9% aged <1 year.. Annual incidence of AFP was 1.3 cases per 100,000 children aged <15 years. Lower limb paralysis was the most frequent presenting symptom. The most frequent diagnoses were Guillain-Barre syndrome (GBS; 36%), transverse myelitis (TM; 17%) and acute disseminated encephalomyelitis (ADEM; 15%). No secular trend was seen in frequency of AFP cases nor amongst major diagnoses. Seasonality was observed with ADEM occurring more frequently in winter. We observed periods of increased AFP frequency in 2013 and 2016, coinciding with increased reporting of non-polio anterior horn cell disease (AHCD) and detection of non-polio enterovirus (NPEV). Conclusions: Estimated incidence of GBS, ADEM and TM in Australian children were comparable with international rates. There was stable incidence of AFP in Australian children between 2007 and 2017. GBS, ADEM and TM are the major causes of AFP. We observed clustering of cases associated with NPEV that emphasises a need for ongoing vigilance in surveillance given continue emerging infectious disease threats.

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“…7 As for neurologists; thiamine deficiency has been reportedly increasingly in both of its forms viz neuropathy and Wernicke's encephalopathy. 8,9 The presence of wet Beri-beri in adults suggests thiamine deficiency in general population. While as Wernicke's encephalopathy in exclusively breast bed infants suggests a maternal thiamine deficiency.…”

Section: Introductionmentioning

confidence: 99%

“…10 In a hospital based study done in Kashmir, Mohsin N et al, found that out of 106 patients of acute flaccid paralysis, eight patients had neuropathy because of thiamine deficiency, out of which 6 were females. 9 Thus there is a suggestion that thiamine deficiency related neuropathy (TDRNP) may be common in females especially in peripartum period in Kashmiri community; but there is lack of literature on this.…”

Section: Introductionmentioning

confidence: 99%

Thiamine deficiency related peripheral neuropathy in peripartum women of Kashmir, India: a hospital based study

Ahmad¹,

Ahmad²,

Jan

2019

Int J Adv Med

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Background: Beri Beri is still seen in Asian countries due to the large-scale consumption of thiamine depleted polished rice. Thiamine deficiency related disorders are increasingly being reported from Kashmir from last two decades. Specifically, a sensorimotor axonal neuropathy occasionally develops from thiamine deficiency and may occur even without associated Wernicke’s encephalopathy.Methods: This study is a retrospective observational study. All peripartum females referred to our departments from January 2016 to December 2017 with complaints of generalized weakness and or sensory symptoms in form of paresthesias /numbness in limbs were enrolled. Clinical features, electrophysiological features, course in hospital and response to treatment in suspected thiamine deficiency related neuropathy patients were recorded.Results: Forty-three cases were included in the study. Twenty-nine patients were suspected to have nutritional neuropathy because of thiamine deficiency at the time of admission. Out of these 27 showed improvement on treatment with thiamine.Conclusions: Thiamine responsive neuropathy is common in peripartum women of this part of world. Diagnosis is usually made clinically, in at risk individuals presenting with characteristic clinical features.

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Clinical profile of acute flaccid paralysis: A study from a tertiary care centre in Kashmir, India

Cited by 5 publications

References 0 publications

Eleven-year surveillance of acute flaccid paralysis in southwestern Iran

Eleven-year surveillance of acute flaccid paralysis in southwestern Iran

Acute Flaccid Paralysis in Australian Children from 2007 to 2017

Thiamine deficiency related peripheral neuropathy in peripartum women of Kashmir, India: a hospital based study

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