Clinical profile of breast cancer in Arab and Jewish women in the Jerusalem area

Nissan, Aviram; Spira, Ram M.; Hamburger, Tamar; Badrriyah, Mahmud; Prus, Diana; Cohen, Tzeela; Hubert, Ayala; Freund, Herbert R.; Peretz, Tamar

doi:10.1016/j.amjsurg.2003.11.039

Cited by 43 publications

(42 citation statements)

References 10 publications

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“…Women with age ≥ 50 years presented in this study with the highest proportions of breast cancer (22%), this result could be matched to a study done in Palestinian Arab Kindred and Jewish population that reported mean ages of breast cancer 51.5 and 55.9 years respectively (Nissan et al, 2004) while other two studies conducted in two different cities in Iraq ;one in kirkuk (Mahmoud, 2014) and the other in Baghdad (Al-Alwan,1998) revealed that the peak age frequency of breast cancer was among patients aged 40-50 years.There are considerable variations in the risk factors other than age such as genetics, racial, social, cultural, hormonal and dietary habits may play a role in the etiopathogenesis of breast cancer (Mir et al, 2017).…”

Section: Demographic and Personal Characteristics Of Women With Breassupporting

confidence: 70%

Patterns of Breast Diseases Among Women Attending Breast Diseases Diagnosing Center in Erbil City/Iraq

Yousif¹,

Yacoub²

2018

GJHS

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Background and Objectives: Breast diseases in women, whether benign or malignant, are very commonly encountered. The pattern of breast diseases varies within countries. The aim of this study was to identify the patterns of breast diseases and their association with different variables in women attending breast diseases diagnosing center in Erbil city/Iraq. Material and Methods:A cross-sectional study conducted at breast diseases diagnosing center in Erbil city from 1 st of April till 1 st of December /2017. A random sample of 500 women of all age groups and with complete records was recruited. The women were classified according to their final diagnosis into 3 categories: normal, benign and malignant breast disease. The level of significance was <0.05. Results:Benign breast diseases diagnosed among (63%) women while malignant breast diseases comprised (13.2%).The most common presentation was mastalgia and mass (39.2%), mastalgia (37.6%), and mass alone (23.2%). Fibro-adenoma (26.2%) was the commonest benign condition with highest incidence (76.9%) in age group less than 20 years. Malignant breast diseases were increasing with age. Benign breast disease associated (p <0.001) with Nulliparity. Breast cancer reported (p <0.001) more among lactating women. Conclusions:Benign conditions are the most common diagnosis affecting mainly younger women. Breast cancer though diagnosed less frequently and affecting older age groups, yet its seriousness mandating a thorough assessment of women of different presentations especially that of mass alone or with mastalgia.

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Section: Demographic and Personal Characteristics Of Women With Breassupporting

confidence: 70%

Patterns of Breast Diseases Among Women Attending Breast Diseases Diagnosing Center in Erbil City/Iraq

Yousif¹,

Yacoub²

2018

GJHS

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“…The HER2 enriched breast cancer is only 6%. In contrast to our finding, Nissan et al found no significant difference in ER and PR expression in Palestinian women (78% being ER+ and 72% PR+ [36]. Studies in other breast cancer patients in middle income countries like India and South Korea indicated relatively higher prevalence of ER+ breast cancer [37,38].…”

Section: Discussioncontrasting

confidence: 54%

Biological and Clinicopathological Characteristics of Breast Cancer at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Shenkutie¹,

Mekonnen²,

Seifu³

et al. 2017

J Cancer Sci Ther

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Breast cancer (BC) is one of the most heterogeneous types of cancer and is characterized by several molecular subtypes. Descriptive cross-sectional study was conducted on 137 confirmed BC cases at Tikur Anbessa Specialized Hospital (TASH) in Ethiopia from December 2015 to November 2016 to assess the biological and clinicopathological characteristics of BC in Ethiopian women patients. Socio-demographic characteristics of the study subjects was obtained with pretested structured interview and clinical data was collected from the Hospital records. Surgical specimens were analysed histopathologically with hematoxyline and eosin staining, and Immunohistochemistry analysis was conducted with specific antibodies to ER, PR and HER2. The mean and median age of the study participants were 47 and 46.7, respectively. More than 50% of the patients were categorized in the age group of 15-40. Sixty percent were in the age group of 41-100. Infiltrating ductal carcinoma was the most common type of BC (70%) in this study, followed by lobular carcinoma (8.5%). Almost all of the BC cases under study were at advanced stage of the disease: 48.5% were with stage III and 51% were grade II tumors. Half of the study participants belonged to T2 tumor size (2-5 cm) and 52.3% of the patients had axillary lymph node metastases. Sixty five percent were ER+, 58% were PR+ and 28% were HER2+. Luminal A was the most common tumor subtype (54%), followed by luminal B (22%) and TNBC (18%). Based on crude analysis, patients with family history of BC had a lesser likelihood of being ER+ as compared to those patients with no family history of BC [COR=0.10 (95% CI: 0.028, 0.34)]. None of the other risk factors were correlated with the prevalence of ER+ results. In conclusion, the age distribution of BC cases in this study suggests the need to create awareness and improvement of advanced diagnostic services and make available screening programs for younger people. In a resource poor setting like Ethiopia, the use of anti-estrogens (like tamoxifen) in treatment of BC cases with undetermined receptor status could be helpful as most BC cases are ER+ and hormonal therapy is relatively easily available.

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“…The average age at presentation of BA patients was 49 years, a decade earlier than Jewish patients. A similar difference in the average age of BC patients between Israeli-Arab women and Jewish patients has previously been reported in patients residing in the Jerusalem area (Nissan et al, 2004), and in northern Israel (Zidan et al, 2012). Several studies reported a similar pattern of earlier diagnosis of BC in Arab countries (Chouchane et al, 2013;Slaou et al, 2014).…”

Section: Discussionsupporting

confidence: 71%

“…The finding of common biologic parameters in BC in BA and in Jewish patients is in contrast to a report on Israeli-Arab patients residing in northern Israel that described a higher proportion of high-grade, triple-negative or Her2-positive tumors in Israeli-Arab compared with Jewish patients (Zidan et al, 2012). As in our study, the proportion of hormone receptor-positive BC in Palestinian patients residing in the district of Jerusalem was similar to that observed in Jewish patients (Nissan et al, 2004). A high proportion of BC showing aggressive patterns including high-grade, triple-negative or Her2-positive tumors was reported in BC patients from Saudi Arabia.…”

Section: Discussioncontrasting

confidence: 59%

Breast Cancer in Bedouin-Arab Patients in Southern Israel: Epidemiologic and Biologic Features in Comparison with Jewish Patients

Lazarev

Flaschner²,

Geffen³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Breast cancer (BC) is the most frequent cancer type and the leading cause of death among women in Israel (BaronApel, Israel Center for Disease Control) a. Time-trends in the incidence of BC have been different in Jewish and Israeli-Arab populations. Following a steady rise over a few decades, the incidence of BC in Jews decreased by 3% from 1996 through 2007. In contrast, the incidence of BC in Israeli-Arabs continued to increase by 98% over the same time-period. Age-adjusted incidence rates in Jews and Israeli-Arabs in 2010 reached levels of 91, and of 53 cases per 100,000 per year, respectively (Israel Cancer Registry, Jerusalem).Bedouin-Arabs (BA), who are part of the Israeli-Arab population of Israel, reside in the Negev, a desert and

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Clinical profile of breast cancer in Arab and Jewish women in the Jerusalem area

Cited by 43 publications

References 10 publications

Patterns of Breast Diseases Among Women Attending Breast Diseases Diagnosing Center in Erbil City/Iraq

Patterns of Breast Diseases Among Women Attending Breast Diseases Diagnosing Center in Erbil City/Iraq

Biological and Clinicopathological Characteristics of Breast Cancer at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

Breast Cancer in Bedouin-Arab Patients in Southern Israel: Epidemiologic and Biologic Features in Comparison with Jewish Patients

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